Lancet Infect Dis：单剂量灭活全细胞口服霍乱疫苗2年有效性研究

2018-03-15 zhangfan MedSci原创

研究认为，对于5岁以上幼儿，单剂量灭活全细胞口服霍乱疫苗可提供至少2年的预防效果，5岁以下幼儿因年龄特异性自然免疫缺乏导致疫苗的持续保护效能下降

单剂量灭活全细胞口服霍乱疫苗(OCV)因接受方便，受益人数众多受到业界的推崇。近日研究人员就OCV接受后2年的保护结果进行了考察。

本次研究在孟加拉开展，1岁以上无OCV接种史的幼儿参与研究，随机接受OCV或安慰剂。研究的主要终点是主要终点是霍乱弧菌阳性非血性腹泻。

205513名幼儿参与研究，其中102552人接种疫苗，在2年的随访期间287人首次发生霍乱，其中疫苗组109人，对照组178人，患者中138人出现严重脱水，其中疫苗组46人，安慰剂组92人。疫苗组每100000患者天中霍乱首次发作0.22例，安慰剂组为0.36例（防护效能为39%），疫苗组每100000患者天中严重脱水0.09例，安慰剂组0.19例（防护效能为50%）。对于5-15岁人群疫苗对霍乱的预防效果为52%，对严重脱水的预防效果为71%，对于15岁以上人群预防效果分别为59%和59%。保护效果对5岁以上参与者可持续2年，但对于5岁以下人群，疫苗对霍乱和严重脱水的预防效果下降分别为-13%和-44%。

研究认为，对于5岁以上幼儿，单剂量灭活全细胞口服霍乱疫苗可提供至少2年的预防效果，5岁以下幼儿因年龄特异性自然免疫缺乏导致疫苗的持续保护效能下降。

原始出处：

Firdausi Qadri et al. Efficacy of a single-dose regimen of inactivated whole-cell oral cholera vaccine： results from 2 years of follow-up of a randomised trial. Lancet Infect Dis. 14 March 2018.

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2018-12-08 howi

#Lancet#

56 0
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2018-04-29 mjldent

#霍乱疫苗#

73 0
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2018-10-15 cmj8wellington

#Dis#

67 0
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2018-03-18 1209e435m98(暂无昵称)

学习了.谢谢分享

108 0
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2018-03-17 121832a9m88暂无昵称

学习了

108 0
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2018-03-17 klivis

#霍乱#

64 0
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2018-03-16 yfjms

学习

117 0
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2018-03-15 戒馋，懒，贪

谢谢分享学习了

116 0
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2018-03-15 lietome2

认真学习.不断进步.把经验分享给同好.点赞了!

110 0

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