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Gastroenterology :炎性肠病的手术风险随着时间推移已逐渐降低

2013-12-02 吴军 编译 医学论坛网

炎性肠病(IBDs)是慢性疾病,通常需要手术治疗;但是随着时间的推移,手术风险情况并未被较好的描述。来自加拿大Calgary大学的Alexandra D. Frolkis等进行了一项系统性综述及荟萃分析,来明确炎症性肠病患者手术累计风险及评价手术风险如何随时间推移而改变。研究结果显示在过去的60年内,炎症性肠病患者的手术风险已逐渐减少。该文发表于近期《胃肠病学》杂志。(

炎性肠病(IBDs)是慢性疾病,通常需要手术治疗;但是随着时间的推移,手术风险情况并未被较好的描述。来自加拿大Calgary大学的Alexandra D. Frolkis等进行了一项系统性综述及荟萃分析,来明确炎症性肠病患者手术累计风险及评价手术风险如何随时间推移而改变。研究结果显示在过去的60年内,炎症性肠病患者的手术风险已逐渐减少。该文发表于近期《胃肠病学》杂志。(Gastroenterology,2013,145:996-1006)【原文下载

研究者搜索了MEDLINE、EMBASE、Pubmed和会议摘要(2009-2012)中与IBD及肠道手术有关文献;2名评价者筛查了8338篇摘要,最终纳入了30篇基于人群的研究,包括文章发表(26篇)和摘要(4篇),报道了在诊断CD或UC后1、5、10年的手术风险。通过meta回归随机效应模型来分析随时间推移手术风险趋势。

基于人群研究,在诊断CD后1年、5年、10年时手术风险分别为16.3% (95%CI,11.4%-23.2%), 33.3% (95%CI,26.3%-42.1%),46.6%(95%CI,37.7%-57.7%);在诊断UC后1年、5年、10年时手术风险分别为4.9% (95%CI,3.8%-6.3%), 11.6% (95%CI, 9.3%-14.4%), 15.6% (95%CI,12.5%-19.6%);在诊断CD后1、5、10年时和诊断UC后1、10年时的手术风险在过去的60年内显著下降。

原文出处

Frolkis AD, Dykeman J, Negrón ME, Debruyn J, Jette N, Fiest KM, Frolkis T, Barkema HW, Rioux KP, Panaccione R, Ghosh S, Wiebe S, Kaplan GG.Risk of Surgery for Inflammatory Bowel Diseases Has Decreased Over Time: A Systematic Review and Meta-analysis of Population-Based Studies.Gastroenterology. 2013 Nov;1【原文下载

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