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Stroke:缺血性卒中或短暂性脑缺血发作患者发生脑微梗死危险因素有哪些?

2016-08-29 fsy 译 MedSci原创

最近有研究表明,脑微梗死(CMIs)可在体内使用3.0特斯拉(T)磁共振成像检测。研究人员调查了在缺血性卒中或短暂性脑缺血发作患者中,使用3.0T磁共振成像检测的大脑皮层CMIs的患病率,危险因素,和纵向认知结果。 该研究共包括231例接受3.0T磁共振成像的患者。蒙特利尔认知评估被用来评估总体认知功能和认知域(记忆,语言和注意视觉空间和执行功能)。蒙特利尔认知评分评估了基线和卒中/短暂

最近有研究表明,脑微梗死(CMIs)可在体内使用3.0特斯拉(T)磁共振成像检测。研究人员调查了在缺血性卒中或短暂性脑缺血发作患者中,使用3.0T磁共振成像检测的大脑皮层CMIs的患病率、危险因素和纵向认知结果。

该研究共包括231例接受3.0T磁共振成像的患者。蒙特利尔认知评估被用来评估总体认知功能和认知域(记忆,语言和注意视觉空间和执行功能)。蒙特利尔认知评分评估了基线和卒中/短暂性脑缺血发作28个月后的认知变化。大脑皮层CMIs和认知功能之间的横截面和纵向联系使用协方差分析及回归模型进行探讨。

共有34例(14.7%)例患者发生大脑皮层CMIs,包括13例急性CMIs(弥散加权成像高信号)和21例慢性CMIs(弥散加权成像等信号)。房颤是所有大脑皮层CMIs的风险因素(比值比4.8;95%置信区间,1.5-14.9;P=0.007)脑白质高信号与慢性CMIs相关(比值比2.8;95%置信区间,1.0-7.8; P=0.047)。在基线时大脑皮层CMIs的存在与基线更差视觉空间功能有关,并且在28个月的随访过程中会下降(β=0.5;95%置信区间,0.1-1.0; P=0.008,并且对脑萎缩、白质高信号、腔梗和微出血进行了调整)。

大脑皮层CMIs是卒中/短暂性脑缺血发作患者常见的疾病。CMI和房颤以及白质高信号之间的关联表明,这些病变有异质性的原因,涉及到微栓塞和脑小血管病。通过认知筛选试验评估,CMI似乎优先影响视觉空间功能。

原始出处:


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    2016-10-06 ylzr123

    好文关注值得学习。赞!有待探究。

    0

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    2016-09-05 李东泽

    很好,不错,以后会多学习

    0

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