eLife:脂肪过多过少都易患糖尿病到底为何？

2016-08-18 佚名生物谷

近日国际学术期刊eLife发表了波士顿大学医学院的一项最新研究进展，对于为何大多数肥胖人群会发展为胰岛素抵抗和2型糖尿病提供了一个可能的解释。少数被称为健康肥胖的肥胖个体仍然具有正常的胰岛素敏感性，不会患有糖尿病。在这项研究中研究人员发现一个叫做PTRF的蛋白在小鼠和人类中缺失都会导致脂肪细胞几乎完全消失，造成脂肪代谢障碍。根据文章作者介绍，缺少脂肪细胞会引起脂肪错位转移到其他组织引起胰岛

近日国际学术期刊eLife发表了波士顿大学医学院的一项最新研究进展，对于为何大多数肥胖人群会发展为胰岛素抵抗和2型糖尿病提供了一个可能的解释。少数被称为健康肥胖的肥胖个体仍然具有正常的胰岛素敏感性，不会患有糖尿病。

在这项研究中研究人员发现一个叫做PTRF的蛋白在小鼠和人类中缺失都会导致脂肪细胞几乎完全消失，造成脂肪代谢障碍。根据文章作者介绍，缺少脂肪细胞会引起脂肪错位转移到其他组织引起胰岛素抵抗，最终发展为2型糖尿病。非常矛盾的情况是是，肥胖个体有大量脂肪细胞，但是仍然会发展为胰岛素抵抗，脂肪仍然会错误转移到其他组织。

研究人员将正常小鼠与缺失PTRF的小鼠进行了对比，还在细胞水平对PTRF的作用进行了研究。细胞需要应答快速的营养变化，通过产生更多蛋白来有效储存脂肪，这些营养变化对应常见的西式高脂饮食。研究人员发现缺少PTRF之后细胞无法产生足够的新蛋白来充分应对饥饿再进食的循环，这对应人类的饮食循环。随后他们进一步在分子水平上研究了PTRF的工作机制。研究人员认为脂肪过多或过少会导致类似的不良后果，而低效的脂肪储存过程可能是这两种情况产生类似结果的原因。

研究人员表示通过揭示PTRF的作用，对脂肪如何分布有更好的了解，这最终将为人类糖尿病治疗找到新机会。作者提醒，2型糖尿病是一种复杂疾病，除了PTRF之外其他蛋白也会促进该病的发生，饮食和锻炼仍然是预防和治疗2型糖尿病的首选方法。

原始出处

Libin Liu ,Paul F Pilch.PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges.eLife.2016

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2017-05-29 膀胱癌

#eLife#

58 0
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2017-02-01 clmlylxy

#Life#

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2016-09-20 1e10c84am36(暂无匿称)

文章很好，非常有益

80 0
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2016-09-12 舒心和人

人体是个很奇妙的个体，一切平衡才是最好的，过犹不及，矫枉过正都不行

94 0
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2016-09-02 1771ae4158m

学习了，有用

89 0
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2016-08-31 李东泽

这篇咨询不错哦，值得学习，对于临床工作和科研思路都很有帮助。

65 0
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2016-08-23 茶马古道

饮食和锻炼仍然是预防和治疗2型糖尿病的首选方

87 0
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encodeId=e501100696ac, content=学习了，赞一个！, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Fri Aug 19 08:08:00 CST 2016, time=2016-08-19, status=1, ipAttribution=)]
2016-08-20 136****0753赵

值得学习

58 0
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2016-08-19 1dd8a7c5m95(暂无匿称)

学习了，赞一个！

54 0
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attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Mon Sep 12 20:25:00 CST 2016, time=2016-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=109893, encodeId=76f7109893a7, content=学习了，有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Fri Sep 02 22:21:00 CST 2016, time=2016-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=108278, encodeId=22531082e813, content=这篇咨询不错哦，值得学习，对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, 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likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLMzGpMQ8w4I7FpiblCXNcmI6O7TDINutbaicEUpoYFR1rWqn3kTbulfMhT0iaPFurLz2ddEcWe3BiciaQ/0, createdBy=5f6e1724878, createdName=136****0753赵, createdTime=Sat Aug 20 15:20:00 CST 2016, time=2016-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=100694, encodeId=0db2100694ef, content=学习了，赞一个！, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Fri Aug 19 08:08:00 CST 2016, time=2016-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=100696, encodeId=e501100696ac, content=学习了，赞一个！, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Fri Aug 19 08:08:00 CST 2016, time=2016-08-19, status=1, ipAttribution=)]
2016-08-19 1dd8a7c5m95(暂无匿称)

学习了，赞一个！

72 0