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Heart:Covid-19患者急性心肌损伤很常见且与预后有关

2020-05-04 MedSci原创 MedSci原创

Covid-19患者常发生急性心肌损伤,且与患者不良预后相关。 原始出处:

近日,心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员旨在调查医疗资源没武汉紧张的中国其他地区Covid-19患者急性心肌损伤的患病率及其对临床结局的直接影响。

研究人员前瞻性地评估了在中国四川两个指定的Covid-19治疗医院内就诊患者的病历、实验室检查结果、胸部CT影像学检查结果和用药情况。感兴趣的结局包括死亡、重症监护病房(ICU)入住情况、机械通气、使用血管活性药物治疗以及疾病严重性分类。急性心肌损伤的定义是高敏感性肌钙蛋白T(hs-TnT)水平超过正常上限。

2020年1月至2020年3月10日期间,该研究共招募了101例病例,平均年龄为49岁,IQR为34-62岁。15.8%的患者存在急性心肌损伤,其中近一半的患者hs-TnT水平是正常上限的五倍。急性心肌损伤患者年龄较大,既往心血管疾病患病率更高,更可能需要入住ICU(62.5% vs. 24.7%,p=0.003),需要机械通气(43.5% vs. 4.7%,p<0.001)和血管活性剂治疗(31.2% vs. 0%,p<0.001)。hs-TnT水平对数与疾病严重程度相关(OR为6.63,95%CI为2.24至19.65),三例死亡病例均发生于急性心肌损伤患者中。

由此可见,Covid-19患者常发生急性心肌损伤,且与患者不良预后相关。

原始出处:

Jia-Fu Wei.et al.Acute myocardial injury is common in patients with covid-19 and impairs their prognosis.heart.2020.http://dx.doi.org/10.1136/heartjnl-2020-317007

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    2020-05-06 zhaojie88
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    2020-05-06 slcumt
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