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JCEM:糖尿病患者肌肉减少症的患病率和危险因素

2022-01-05 MedSci原创 MedSci原创

肌肉减少症在糖尿病患者中更为普遍。

国际糖尿病联合会的调查结果显示,2019年全球糖尿病患病率估计为9.3%(4.63亿人)。预计到2045年,它将影响6.93亿成年人。由于血糖控制不佳,糖尿病患者可能会出现多种并发症。糖尿病性肌肉减少症是近年来备受关注的糖尿病并发症。肌肉减少症被认为与糖尿病患者胰岛素抵抗和氧化应激相关,导致肌肉力量和肌肉质量下降,以及肌肉萎缩。糖尿病患者的肌肉减少症患病率是非糖尿病患者的三倍,并且与预后不良有关。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在调查糖尿病患者肌肉减少症的全球整体患病率和危险因素的情况。

研究人员检索了PubMed、Embase、WebofScience、万方、CNKI、VIP和CBM数据库中的相关研究,检索时间截至2020年11月30日。研究人员选择了年龄≥18岁且临床诊断为糖尿病的参与者。性别和糖尿病类型不受限制。各个研究的数据由两名评价员独立使用标准数据收集表进行提取。

通过荟萃分析,糖尿病患者肌肉减少症的合并患病率为18%(95%CI为16-20);亚组分析显示,肌肉减少症在男性中比在女性中更常见,并且在亚洲比在南美洲和大洋洲更常见。年龄(OR为1.10)、HbA1c(OR为1.16)、内脏脂肪面积(VFA)(OR为1.03)、糖尿病肾病(OR为2.54)、糖尿病病程(OR为1.06)和高敏C反应蛋白(HS-CRP,OR为1.33)是糖尿病患者肌肉减少症的危险因素。

由此可见,肌肉减少症在糖尿病患者中更为普遍。年龄、HbA1c、内脏脂肪面积(VFA)、糖尿病肾病、糖尿病病程和HS-CRP是其可能的危险因素。今后,医务人员不仅要重视高危人群肌肉减少症的早期筛查,还要尽可能为患者提供预防信息。

原始出处:

Liyuan Feng.et al.Prevalence and risk factors of sarcopenia in patients with diabetes: A meta-analysis.JCEM.2021.https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgab884/6460766.

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    2022-07-07 仁者大医
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    2022-02-10 achengzhao
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    2022-01-09 419040982

    0

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