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Plos Med:卒中和短暂性脑缺血发作一级预防药物治疗需要加大处方力度!

2016-11-29 haofan MedSci原创

超过一半的人适合降脂、抗凝或抗高血压药物治疗,但在发生第一次卒中和短暂性脑缺血发作之前在处方中都没有写明需要服用这些药物。研究人员估计,如果通过将这些药物最佳时机写入处方,在英国每年约有12000次卒中事件可能会被预防。提高降脂、抗凝和抗高血压药物写入处方的比例是降低卒中和短暂性脑缺血发作发病率和负担的重要措施。

卒中是导致死亡和残疾的主要原因,据估计,全球每年有1690万人发生卒中。降脂、抗凝和抗高血压药物治疗可以预防卒中,但可能预防性治疗普及仍然不够充分。近日,来自于英国伯明翰大学应用健康研究所的Grace M. Turner博士及其研究团队在Plos Medicine杂志上发表文章,旨在评估卒中预防治疗的现状。

研究人员分析了来自大约覆盖了6%的英国人口的英国初级保健数据库内匿名电子病历。该研究纳入了年龄不小于18岁、并于2009年1月1日至2013年12月31日期间第一次被诊断为卒中/短暂性脑缺血发作的患者。预防药物使用不充分是指当存在降脂、抗凝或抗高血压药物治疗的临床指征时,但在卒中或短暂性脑缺血发作发生之前给予这些处方药进行治疗。当存在临床指征时,研究人员计算了预防药物在卒中或短暂性脑缺血发作时使用不充分的比例。

总之,共有29,043名脑卒中/短暂性脑缺血发作的患者符合纳入标准,其中17,680名参与者有一个或以上的预防性药物使用临床指征:16,028名参与者有使用降脂药物治疗的指征,3194名参与者有使用抗凝药物治疗的指征和7008名参与者有使用抗高血压药物治疗的指征。


54%(9579/17,680)有临床指征的脑卒中/短暂性脑缺血发作患者至少有一个预防性治疗药物没有被写入处方中:49%(7836/16,028)的参与者未服用降脂药,52%(1647/3194)的参与者未服用抗凝药物和25%(1740/7008)的参与者未服用抗高血压药物。

在该研究中,超过一半的人适合降脂、抗凝或抗高血压药物治疗,但在发生第一次卒中和短暂性脑缺血发作之前在处方中都没有写明需要服用这些药物。研究人员估计,如果将这些药物在最佳时机写入处方,那么在英国每年约有12,000次卒中事件可能会被预防。提高降脂、抗凝和抗高血压药物写入处方的比例是降低卒中和短暂性脑缺血发作发病率和负担的重要措施。

原始出处:


Grace M. Turner, et al. Under-prescribing of Prevention Drugs and Primary Prevention of Stroke and Transient Ischaemic Attack in UK General Practice: A Retrospective Analysis.  Plos medicine.November 15, 2016.

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    2016-12-06 李东泽

    很好,不错,以后会多学习

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1800811, encodeId=a9dc180081111, content=<a href='/topic/show?id=8a3be319614' target=_blank style='color:#2F92EE;'>#短暂性脑缺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73196, encryptionId=8a3be319614, topicName=短暂性脑缺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9c94141, createdName=liuquanmn, createdTime=Wed Apr 19 06:34:00 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764503, encodeId=97f31e6450346, content=<a href='/topic/show?id=1612e319263' target=_blank style='color:#2F92EE;'>#短暂性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73192, encryptionId=1612e319263, topicName=短暂性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b6237741961, createdName=12498ca5m95暂无昵称, createdTime=Tue Oct 10 08:34:00 CST 2017, time=2017-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160563, encodeId=3f571605635b, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Dec 06 06:50:15 CST 2016, time=2016-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289186, encodeId=50771289186b0, content=<a href='/topic/show?id=cd268500578' target=_blank style='color:#2F92EE;'>#脑缺血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85005, encryptionId=cd268500578, topicName=脑缺血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Thu Dec 01 01:34:00 CST 2016, time=2016-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607211, encodeId=38bf160e21140, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Dec 01 01:34:00 CST 2016, time=2016-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158988, encodeId=62a31589887b, content=学习吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KzY0AKCuyeYpTTaavxw0sXDXf9bgFIAibrIkIibicM8SBLudBK2V7LsgwyHAE9d47dh6RjO8TnjfWkk/0, createdBy=56af1959811, createdName=CardioK, createdTime=Tue Nov 29 23:11:12 CST 2016, time=2016-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158980, encodeId=539b1589801d, content=一级预防很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161224/IMG585DA5E26B9F44696.jpg, createdBy=565a98798, createdName=susice, createdTime=Tue Nov 29 22:08:00 CST 2016, time=2016-11-29, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1800811, encodeId=a9dc180081111, content=<a href='/topic/show?id=8a3be319614' target=_blank style='color:#2F92EE;'>#短暂性脑缺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73196, encryptionId=8a3be319614, topicName=短暂性脑缺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9c94141, createdName=liuquanmn, createdTime=Wed Apr 19 06:34:00 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764503, encodeId=97f31e6450346, content=<a href='/topic/show?id=1612e319263' target=_blank style='color:#2F92EE;'>#短暂性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73192, encryptionId=1612e319263, topicName=短暂性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b6237741961, createdName=12498ca5m95暂无昵称, createdTime=Tue Oct 10 08:34:00 CST 2017, time=2017-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160563, encodeId=3f571605635b, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Dec 06 06:50:15 CST 2016, time=2016-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289186, encodeId=50771289186b0, content=<a href='/topic/show?id=cd268500578' target=_blank style='color:#2F92EE;'>#脑缺血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85005, encryptionId=cd268500578, topicName=脑缺血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Thu Dec 01 01:34:00 CST 2016, time=2016-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607211, encodeId=38bf160e21140, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Dec 01 01:34:00 CST 2016, time=2016-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158988, encodeId=62a31589887b, content=学习吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KzY0AKCuyeYpTTaavxw0sXDXf9bgFIAibrIkIibicM8SBLudBK2V7LsgwyHAE9d47dh6RjO8TnjfWkk/0, createdBy=56af1959811, createdName=CardioK, createdTime=Tue Nov 29 23:11:12 CST 2016, time=2016-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158980, encodeId=539b1589801d, content=一级预防很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161224/IMG585DA5E26B9F44696.jpg, createdBy=565a98798, createdName=susice, createdTime=Tue Nov 29 22:08:00 CST 2016, time=2016-11-29, status=1, ipAttribution=)]
    2016-11-29 CardioK

    学习吧

    0

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    2016-11-29 susice

    一级预防很重要

    0

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