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Atherosclerosis: baPWV与缺血性卒中患者的预后相关

2016-11-05 MedSci MedSci原创

背景:臂踝脉搏波传导速度(baPWV)是测量动脉僵硬度的良好指标,且与未来发生心血管事件的风险相关。本研究旨在探讨baPWV是否可以预测卒中后3个月的功能预后。方法:这项基于医院的研究包括327例缺血性卒中患者,住院期间测量baPWV。其中,良好和较差的功能预后为卒中后3个月内,改良Rankin评分<3和≥3。结果:预后不良的患者与高龄,(73.1 vs 66.3岁,P<0.001),更可能有颈动

背景:臂踝脉搏波传导速度(baPWV)是测量动脉僵硬度的良好指标,且与未来发生心血管事件的风险相关。本研究旨在探讨baPWV是否可以预测卒中后3个月的功能预后。

方法:这项基于医院的研究包括327例缺血性卒中患者,住院期间测量baPWV。其中,良好和较差的功能预后为卒中后3个月内,改良Rankin评分<3和≥3。

结果:预后不良的患者与高龄,(73.1 vs 66.3岁,P<0.001),更可能有颈动脉狭窄(29.5% vs 13.1%,P<0.001),房颤(21% vs 11.3%,P = 0.020),冠状动脉疾病史(20% vs 11.7%,P = 0.042),和高baPWV值(22.84 vs 19.48 m/s,P<0.001)。不论患者的年龄、性别、基线危险因素,卒中的严重程度,以及脑卒中病因,预后不良的患者中,baPWV较高。多因素分析显示ROC计算,baPWV > 23.11m/Ss 是功能预后不良的独立预测价值(OR,1.51;95%CI,1.08-2.11;P = 0.016)。

结论:在脑卒中急性期测量baPWV可独立预测3个月的功能预后。研究表明,baPWV可作为早期识别严重卒中相关残疾的患者。

原始出处:

Ishizuka K, Hoshino T,et al. Brachial-ankle pulse wave velocity is associated with 3-month functional prognosis after ischemic stroke. Atherosclerosis. 2016 Aug 26


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