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关键Y染色体基因功能丧失会增加男性患癌风险

2020-01-20 Allan MedSci原创

许多研究表明,男性比女性更容易患癌症,但科学界对这种差异的原因仍知之甚少。巴塞罗那全球健康研究所(ISGlobal)的研究人员进行了一项研究,发现了导致男性罹患癌症风险更高的关键生物学机制:某些Y染色体性别基因的功能丧失。

许多研究表明,男性比女性更容易患癌症,但科学界对这种差异的原因仍知之甚少。巴塞罗那全球健康研究所(ISGlobal)的研究人员进行了一项研究,发现了导致男性罹患癌症风险更高的关键生物学机制:某些Y染色体性别基因的功能丧失。研究人员利用来自9,000例患者的数据,研究了各种癌症患者的Y染色体基因功能。研究结果表明,癌症风险随着关键Y染色体基因功能的丧失而增加。

Y染色体是属于XY性别决定系统的大多数哺乳动物(包括人类)的两条性染色体之一。在哺乳动物的Y染色体中含有的SRY基因能触发睾丸的生长,并由此决定雄性性状。人类的Y染色体中包含约6千万个碱基对。


原始出处:

https://www.firstwordpharma.com/node/1694585?tsid=28®ion_id=4

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time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378353, encodeId=6cc43e83532f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 20 21:09:49 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
    2023-09-02 侠胆医心 来自上海

    关键#Y染色体#基因功能丧失会增加男性患癌风险#癌症#

    0

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time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378353, encodeId=6cc43e83532f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 20 21:09:49 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
    2020-01-23 125077a8m60暂无昵称

    好的

    0

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time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378353, encodeId=6cc43e83532f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 20 21:09:49 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
    2020-01-23 thm112988

    0

  5. 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time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378353, encodeId=6cc43e83532f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 20 21:09:49 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
  6. 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time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378353, encodeId=6cc43e83532f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 20 21:09:49 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
  7. 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00:07:00 CST 2020, time=2020-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601463, encodeId=4baf160146352, content=<a href='/topic/show?id=5baa5299111' target=_blank style='color:#2F92EE;'>#患癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52991, encryptionId=5baa5299111, topicName=患癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=888f18872716, createdName=lq0307, createdTime=Wed Jan 22 00:07:00 CST 2020, time=2020-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378382, encodeId=2bdb3e8382b1, content=看来少了一条腿就是不行啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43a21971117, createdName=njwbhuang, createdTime=Tue Jan 21 22:02:58 CST 2020, time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378353, encodeId=6cc43e83532f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 20 21:09:49 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
    2020-01-22 周虎
  8. 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time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378353, encodeId=6cc43e83532f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 20 21:09:49 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
    2020-01-22 lq0307
  9. 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time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378353, encodeId=6cc43e83532f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 20 21:09:49 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
    2020-01-21 njwbhuang

    看来少了一条腿就是不行啊

    0

  10. 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time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378353, encodeId=6cc43e83532f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 20 21:09:49 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
    2020-01-20 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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日益恶化的环境和快速的都市生活让无精、少精、弱精、精子畸形导致不育的年轻男性越来越多。Y染色体微缺失的分子诊断是少精子症和无精子症男性不育患者的常规基因检测项目。自1999年以来,欧洲男科学协会和欧洲分子遗传实验质控作网(EMQN/EAA)一直致力于提高Y染色体微缺失分子诊断质量,并出版了Y染色体微缺失分子诊断指南,提供了一套客观的检测质量评价实验方法。经过10年不断地临床积累,2013年9月19

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一项新的研究表明,随着年龄的增长,男性血液细胞中的Y染色体会逐渐损失,这可能会增加老年痴呆症的患病风险。在该项研究中,研究者们对3,200多人的相关信息进行了研究,研究发现,阿尔茨海默氏症患者的血细胞中Y染色体损失量是正常人群的近三倍。更重要的是,“Y染色体损失”的老年男性在未来八年内,将会面临更高的阿尔茨海默氏症患病风险。专家表示,该项研究并不能证明:Y染色体损失直接引起了阿尔茨海默氏症,只能说

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据公安部刑事侦查局官方微博消息,8月26日,自1988年起连续在14年间强奸、杀害多名女性的犯罪嫌疑人高某在甘肃省白银市落网。高某对犯罪事实供认不讳,甘蒙“8·05”系列强奸杀人残害女性案成功告破。 1988年至2002年,甘肃省白银市白银区先后发生多起强奸残害女性的系列杀人案件,首案距今已有28年之久。期间,内蒙古自治区包头市昆都仑区也发生过类似案件。犯罪分子作案手段十分残忍,不仅强奸

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本周有研究人员在欧洲人类遗传学会议提出,男性红细胞缺乏Y染色体更容易患阿尔茨海默症。研究人员希望,在未来这些发现可能有助于帮助筛查阿尔茨海默症患者并及早采取预防和治疗措施。约有500万名美国人患有阿尔茨海默症,相当于65岁以上的民众中有1/9的老人患有该病。预计到2050年,共有1400万名美国人患有该病。 尽管阿尔茨海默症患者数目众多,但研究人员尚未能了解其背后的分子机制,对相关风险因素也知之甚

Sci Rep:没有Y染色体也可以变成“男人”

图片来源:www.phys.org 近日,一项刊登在国际杂志Scientific Reports上的研究报告中,来自北海道大学的研究人员通过研究发现,关键的性别决定基因或许能在缺失Y染色体的哺乳动物机体中继续发挥作用,该研究对于理解性别分化的分子机制或将提供新的思路。 在很多胎盘哺乳动物(placental mammals)机体发育过程中,Y染色体能够诱导雄性分化,性别决定基因SRY存在于

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