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Int J Epidemiol:出生体重会影响晚年的左心室结构吗?

2016-09-27 Moon 译 MedSci原创

高左心室质量(LVM)是心血管疾病和死亡率的独立预测因子。我们进行了一项研究,评估出生体重、升高和BMI,以及儿童期和青少年时间超重,与晚年(60-64岁)左心室(LV)结构之间的关系。 研究纳入了出生于英国、1946年的参与者,自出生开始进行随访。数据来自MRC全国性健康和发展调查(NSHD)。我们使用回归模型,评估出生体重、身高、BMI与60-64岁时LV结构之间的联系。 结果表明

高水平的左心室质量(LVM)是心血管疾病和死亡率的独立预测因子。我们进行了一项研究,评估出生体重、身高和BMI,以及儿童期和青少年时间超重,与晚年(60-64岁)左心室(LV)结构之间的关系。

研究纳入了1946年出生于英国的参与者,自出生开始进行随访。数据来自MRC全国性健康和发展调查(NSHD)。我们使用回归模型,评估出生体重、身高、BMI与60-64岁时LV结构之间的联系。

结果表明,出生体重与60-64岁时的LVM和左室舒张末期容积(LVEDV)呈正相关,成年身高是这种关联性的主要原因。整个童年和青少年时期,更高的BMI、更大的BMI变化和更大的累积超重,与更高的LVM、LVEDV和向心性肥厚几率有关。

生命头两年超重的参与者,与不超重的参与者相比,平均LVM高出11.5 g(95% CI -2.19,24.87),平均LVEDV高出10.0 ml(3.7,16.2)。这种联系的部分原因可能是成人的BMI。

身体大小与相对壁厚(RWT)的关联性结果不一致,青春期的BMI变化与RWT关联最密切(7-15岁,BMI每变化1SD,0.007 (0.001,0.013))。更高的儿童身高与LVM和LVEDV之间的联系,可以通过成年人身高来解释。

鉴于在当代儿童中,超重发生率在增加,这些研究结果进一步强调了有效干预措施的必要性,以防止儿童超重。

原始出处:

Rebecca Hardy,et al.Birthweight, childhood growth and left ventricular structure at age 60–64 years in a British birth cohort study.Int. J. Epidemiol. first published online July 13, 2016

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    2016-10-23 jyzxjiangqin

    出生体重会影响晚年的左心室结构。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2006292, encodeId=b73e200629244, content=<a href='/topic/show?id=8cdf48054d5' target=_blank style='color:#2F92EE;'>#左心室结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48054, encryptionId=8cdf48054d5, topicName=左心室结构)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca6a2500099, createdName=more is better!, createdTime=Tue Aug 22 00:58:00 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=150485, encodeId=c2c715048555, content=出生体重会影响晚年的左心室结构。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Oct 23 07:03:19 CST 2016, time=2016-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148035, encodeId=63b91480353a, content=这种说法不科学。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Oct 14 07:32:02 CST 2016, time=2016-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413173, encodeId=ae0014131e34d, content=<a href='/topic/show?id=1d7e48033f5' target=_blank style='color:#2F92EE;'>#左心室#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48033, encryptionId=1d7e48033f5, topicName=左心室)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15012955474, createdName=wushaoling, createdTime=Thu Sep 29 12:58:00 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440734, encodeId=2a3c1440e345c, content=<a href='/topic/show?id=f99e3142e4d' target=_blank style='color:#2F92EE;'>#出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31427, encryptionId=f99e3142e4d, topicName=出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ffd4758992, createdName=ms9608593228839890, createdTime=Thu Sep 29 12:58:00 CST 2016, time=2016-09-29, status=1, ipAttribution=)]
    2016-10-14 jyzxjiangqin

    这种说法不科学。

    0

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