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Hypertension:孤立性舒张期高血压

2021-10-06 MedSci原创 MedSci原创

该研究使用动态血压监测数据表明,2017年美国心脏病学会/美国心脏协会标准定义的IDH不是50岁或以上成年人心血管疾病的危险因素,而是年轻人的危险因素。因此,在成人IDH的临床治疗中,年龄是一个重要的

根据2017年美国心脏病学会(ACC)/美国心脏协会(AHA)指南定义的孤立性舒张期高血压(IDH)的预后意义尚未使用动态血压(BP)监测阈值(即24小时平均收缩压<125 mmHg和舒张压≥75mmHg)进行检验。

近日,血管权威杂志Hypertension上发表了一篇研究文章,研究人员分析了来自IDACO(与心血管结果相关的动态血压国际数据库)中11135名参与者的数据。

研究人员使用24小时平均动态血压监测值,进行了Cox回归评估了IDH与死亡或心血管事件之间的独立关联。在整个队列中以及在年龄分层后(50岁以下 vs. 50岁以上)进行了分析。

基线时的中位年龄为54.7岁,49%为女性。在中位随访13.8年期间,2836名参与者死亡,2049名参与者发生心血管事件。总体而言,无论年龄如何,根据2017年美国心脏病学会/美国心脏协会标准定义且从24小时动态血压监测仪发现的IDH与死亡(风险比为0.95[95%CI为0.79-1.13])或心血管事件无显著相关性(风险比为1.14[95%CI为0.94-1.40]),相比于正常血压。然而,在50岁以下的亚组中,IDH与心血管事件过高风险相关(2.87[95%CI为1.72-4.80]),有证据表明基于年龄的效应修正(交互作用P<0.001)。

总之,该研究使用动态血压监测数据表明,2017年美国心脏病学会/美国心脏协会标准定义的IDH不是50岁或以上成年人心血管疾病的危险因素,而是年轻人的危险因素。因此,在成人IDH的临床治疗中,年龄是一个重要的考虑因素。

原始出处:

John W. McEvoy.et al.Isolated Diastolic Hypertension in the IDACO Study: An Age-Stratified Analysis Using 24-Hour Ambulatory Blood Pressure Measurement.Hypertension.2021.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.121.17766

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    2022-01-24 feather89
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    2021-10-06 junebenf

    大约学习了

    0

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