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J Hypertens:透析患者用动态动脉硬度指数评估动脉硬化程度合适吗?

2017-05-21 xing.T MedSci原创

在血液透析患者中,AASI在评估动脉硬化程度上的价值有限,无论是单独使用或添加到PP。该研究结果表明,在今后的实践和研究中,该指标不应作为透析患者动脉硬化程度的评价指标。

动态动脉硬化指数(AASI)是来自于动态血压(ABP)读数的一个参数。它的计算方法为1减去舒张压比上收缩压的线性斜率。近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,研究人员检验了采用AASI评估透析患者动脉硬化程度的价值。

研究人员对来自于一项队列研究的基线数据进行了横断面分析。来自于六个三级医院的进行持续血液透析的344例患者被纳入研究。所有患者进行了动态血压监测和颈-股脉搏波速度(cfPWV)测量。研究人员分析了AASI的临床影响因素,并将AASI评估动脉硬化程度的能力与动态脉压(PP)进行了比较。

多元回归分析显示,动态PP(β=0.003)、当前吸烟(β=-0.069)、年龄(β=0.003)和动态收缩压(β=0.001)是AASI的独立危险因素。动态PP比AASI更好地与cfPWV相关(AASI的r=0.28,PP的r=0.59;P<0.001)。当cfPWV作为分类变量,ROC曲线分析还显示PP比AASI具有更有效的预测值(曲线下面积:AASI为0.64,PP为0.80;P<0.001)。净重分类改善和综合判别改善分析证明AASI相比于PP没有额外的预测值(净重分类改善 =-2.2%,P=0.26  ;综合判别改善=0.001,P=0.51)。在更多的ABP读数(读数≥49)患者中,敏感性分析得到了类似的结果。

在血液透析患者中,AASI在评估动脉硬化程度上的价值有限,无论是单独使用或添加到PP。该研究结果表明,在今后的实践和研究中,该指标不应作为透析患者动脉硬化程度的评价指标。

原始出处:

Liu, Wenjin.et al. Ambulatory arterial stiffness index and its role in assessing arterial stiffness in dialysis patients.Journal of Hypertension. 2017. http://journals.lww.com/jhypertension/Abstract/2017/06000/Ambulatory_arterial_stiffness_index_and_its_role.24.aspx

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    2017-05-21 dhzzm

    学习了分享了

    0

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    2017-05-21 衣带渐宽

    学习

    0

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    2017-05-21 1e1b8538m79(暂无匿称)

    看完感觉收获蛮多

    0

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    2017-05-21 Medsci0421

    谢谢分享!

    0

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