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JAMA SURGERY:减肥手术患者银屑病及银屑病关节炎的发病率及预后

2017-05-07 MedSci MedSci原创

银屑病与肥胖关系显着,降低体重可以改善银屑病症状。JAMA SURGERY近期报道了一篇文章,研究接受减肥手术(胃旁路术及胃束带术)患者银屑病及银屑病关节炎发病率及预后。

银屑病与肥胖关系显着,降低体重可以改善银屑病症状。JAMA SURGERY近期报道了一篇文章,研究接受减肥手术(胃旁路术及胃束带术)患者银屑病及银屑病关节炎发病率及预后。

作者回顾性分析了12364例胃旁路术患者及1071例胃束带术患者。研究终点为银屑病或银屑病关节炎发病率,或进展为严重银屑病。计算每1000人发病率,使用Cox回归模型评估风险比(HR)。研究初始胃旁路术组有9480例女性,2884例男性。研究开始时患者平均年龄27.8岁,手术时患者平均年龄41.0岁。研究初始胃束带组有800例女性患者,271例男性患者。研究开始时平均年龄为32.3岁,手术时患者平均年龄为41.7岁。胃旁路术组银屑病风险比为0.52,胃束带术组银屑病风险比为1.23.胃旁路术组进展为严重银屑病的风险比为0.44,胃束带术组进展为严重银屑病的风险比为1.18。胃旁路术组及胃束带术组银屑病关节炎风险比分别为0.29和0.53。

文章最后认为,胃旁路术与银屑病及银屑病关节炎风险降低及预后改善有关。这一现象可能是由于术后营养摄入、体重降低不同以及调节炎症反应的激素分泌水平不同引起。

原始出处:
Alexander Egeberg,Jens Ahm Sorensen,et al.Incidence and Prognosis of Psoriasis and Psoriatic Arthritis in Patients Undergoing Bariatric Surgery.JAMA SURGERY.April 2017 doi:10.1001/jamasurg.2016.4610

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    2018-04-18 chg121
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  4. 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encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Tue May 09 01:08:00 CST 2017, time=2017-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195447, encodeId=48ed19544e7c, content=这个观点有点意思,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 08 16:38:23 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195204, encodeId=d15419520470, content=学习了分享了!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhbPwBo0yCebU4qpdSwzpBA1WFXMEUicoTnJDickpj9Ve1cUdNjjTiaDXmpXL47LYh3DdYkPOA2kddyZ/0, createdBy=508c2054450, createdName=solarjin, createdTime=Sun May 07 12:22:06 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194984, encodeId=2d2e194984a6, content=具体机制没有研究吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Sun May 07 11:22:45 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194981, encodeId=808d194981a2, content=不错哦,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epr1MZHfgreGEFrpiapjCGIQGZhkpjicialc8h7VoU0AjNiaSgpaZjNuIqq1KVbmI19JwrN2sdwTdWVSw/132, createdBy=f6692009961, createdName=sy3923582, createdTime=Sun May 07 11:20:52 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-09 lmm397
  5. 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channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epr1MZHfgreGEFrpiapjCGIQGZhkpjicialc8h7VoU0AjNiaSgpaZjNuIqq1KVbmI19JwrN2sdwTdWVSw/132, createdBy=f6692009961, createdName=sy3923582, createdTime=Sun May 07 11:20:52 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-08 1e1b8538m79(暂无匿称)

    这个观点有点意思,不错

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhbPwBo0yCebU4qpdSwzpBA1WFXMEUicoTnJDickpj9Ve1cUdNjjTiaDXmpXL47LYh3DdYkPOA2kddyZ/0, createdBy=508c2054450, createdName=solarjin, createdTime=Sun May 07 12:22:06 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194984, encodeId=2d2e194984a6, content=具体机制没有研究吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Sun May 07 11:22:45 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194981, encodeId=808d194981a2, content=不错哦,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epr1MZHfgreGEFrpiapjCGIQGZhkpjicialc8h7VoU0AjNiaSgpaZjNuIqq1KVbmI19JwrN2sdwTdWVSw/132, createdBy=f6692009961, createdName=sy3923582, createdTime=Sun May 07 11:20:52 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-08 大爰

    学习了分享了!!

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhbPwBo0yCebU4qpdSwzpBA1WFXMEUicoTnJDickpj9Ve1cUdNjjTiaDXmpXL47LYh3DdYkPOA2kddyZ/0, createdBy=508c2054450, createdName=solarjin, createdTime=Sun May 07 12:22:06 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194984, encodeId=2d2e194984a6, content=具体机制没有研究吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Sun May 07 11:22:45 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194981, encodeId=808d194981a2, content=不错哦,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epr1MZHfgreGEFrpiapjCGIQGZhkpjicialc8h7VoU0AjNiaSgpaZjNuIqq1KVbmI19JwrN2sdwTdWVSw/132, createdBy=f6692009961, createdName=sy3923582, createdTime=Sun May 07 11:20:52 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-07 半夏微凉

    胃旁路术与银屑病及银屑病关节炎风险降低及预后改善有关。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1877694, encodeId=b54718e7694b9, content=<a href='/topic/show?id=b013169237f' target=_blank style='color:#2F92EE;'>#surgery#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16923, encryptionId=b013169237f, topicName=surgery)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Wed Apr 18 22:08:00 CST 2018, time=2018-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2021566, encodeId=b29320215664b, content=<a href='/topic/show?id=31e8e9669d' target=_blank style='color:#2F92EE;'>#GER#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7966, encryptionId=31e8e9669d, topicName=GER)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, 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createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon May 08 06:24:51 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195036, encodeId=567e19503664, content=胃旁路术与银屑病及银屑病关节炎风险降低及预后改善有关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sun May 07 15:26:32 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195010, encodeId=997d195010f4, content=体重减轻有助于降低银屑病发病, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhbPwBo0yCebU4qpdSwzpBA1WFXMEUicoTnJDickpj9Ve1cUdNjjTiaDXmpXL47LYh3DdYkPOA2kddyZ/0, createdBy=508c2054450, createdName=solarjin, createdTime=Sun May 07 12:22:06 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194984, encodeId=2d2e194984a6, content=具体机制没有研究吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Sun May 07 11:22:45 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194981, encodeId=808d194981a2, content=不错哦,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epr1MZHfgreGEFrpiapjCGIQGZhkpjicialc8h7VoU0AjNiaSgpaZjNuIqq1KVbmI19JwrN2sdwTdWVSw/132, createdBy=f6692009961, createdName=sy3923582, createdTime=Sun May 07 11:20:52 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-07 solarjin

    体重减轻有助于降低银屑病发病

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1877694, encodeId=b54718e7694b9, content=<a href='/topic/show?id=b013169237f' target=_blank style='color:#2F92EE;'>#surgery#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16923, encryptionId=b013169237f, topicName=surgery)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Wed Apr 18 22:08:00 CST 2018, time=2018-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2021566, encodeId=b29320215664b, content=<a href='/topic/show?id=31e8e9669d' target=_blank style='color:#2F92EE;'>#GER#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7966, encryptionId=31e8e9669d, topicName=GER)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, 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createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon May 08 06:24:51 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195036, encodeId=567e19503664, content=胃旁路术与银屑病及银屑病关节炎风险降低及预后改善有关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sun May 07 15:26:32 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195010, encodeId=997d195010f4, content=体重减轻有助于降低银屑病发病, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhbPwBo0yCebU4qpdSwzpBA1WFXMEUicoTnJDickpj9Ve1cUdNjjTiaDXmpXL47LYh3DdYkPOA2kddyZ/0, createdBy=508c2054450, createdName=solarjin, createdTime=Sun May 07 12:22:06 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194984, encodeId=2d2e194984a6, content=具体机制没有研究吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Sun May 07 11:22:45 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194981, encodeId=808d194981a2, content=不错哦,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epr1MZHfgreGEFrpiapjCGIQGZhkpjicialc8h7VoU0AjNiaSgpaZjNuIqq1KVbmI19JwrN2sdwTdWVSw/132, createdBy=f6692009961, createdName=sy3923582, createdTime=Sun May 07 11:20:52 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-07 lyh994

    具体机制没有研究吗?

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhbPwBo0yCebU4qpdSwzpBA1WFXMEUicoTnJDickpj9Ve1cUdNjjTiaDXmpXL47LYh3DdYkPOA2kddyZ/0, createdBy=508c2054450, createdName=solarjin, createdTime=Sun May 07 12:22:06 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194984, encodeId=2d2e194984a6, content=具体机制没有研究吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Sun May 07 11:22:45 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194981, encodeId=808d194981a2, content=不错哦,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epr1MZHfgreGEFrpiapjCGIQGZhkpjicialc8h7VoU0AjNiaSgpaZjNuIqq1KVbmI19JwrN2sdwTdWVSw/132, createdBy=f6692009961, createdName=sy3923582, createdTime=Sun May 07 11:20:52 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-07 sy3923582

    不错哦,学习了

    0

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虽然减肥手术后会出现长期体重反弹,但仍能在一定程度上抵抗2型糖尿病的复发或发展。这项研究的目的是,调查脂肪功能有没有得到减肥手术的益处。 研究对象为49例肥胖女性,在Roux-en-Y胃旁路术(RYGB)前、术后2年和5年进行了调查。在5年的随访中,对30名受试者进行BMI和年龄上的匹配(30名对照组女性)。测定脂肪细胞的大小和数量、脂解作用、脂联素和炎性分泌蛋白。 2年后,BMI从4

Obstet Gynecol:既往进行减肥手术的妇女妊娠时腹部手术的风险如何?

由此可见,减肥手术与妊娠期间腹部手术的风险增加相关。

警惕:减肥手术对胃肠道的不良反应

腹腔镜胃旁路术是治疗肥胖症的有效方法,但一项新的研究发现,接受该手术的病人常常抱怨有胃肠道问题。 这项研究的对象包括249位接受减肥手术的肥胖患者和295名肥胖控制者,他们都完成了一项问卷调查。进行手术治疗的患者在手术后两年完成问卷。 进行了手术治疗的肥胖患者经常有消化不良症状。此外,还表现为食物不耐受,特别是对高脂肪或高糖含量的食物以及红肉。这是一种常见手术后副作用:70.7%的手术患者术后

Ann Surg:减少减肥手术后急诊人数的影响因素

减肥手术后的许多急诊(ED)访问人群不会重新入院,这些人群就诊于ED也许是可以预防的。目前,评估围手术措施的作用以减少术后ED访问的相关研究很少。因此,了解这些可以预防的ED访问背后的驱动因素可能是一个富有成效的预防措施。此外,评估当前围手术期措施的疗效可以揭示如何有效减少ED访问。近期,一项发表在杂志Ann Surg上的研究旨在探讨密歇根州的减肥手术措施对减少术后ED访问的效果。研究者们自201

病态肥胖者还是先接受减肥手术,再进行关节置换术吧

美国髋膝关节外科医师协会年会上有数据显示,病态肥胖患者在全关节置换术前进行减肥手术,可减少术前合并症负担和人工关节置换术时的并发症负担。 Ashley E. Levack博士说:“我们都知道美国的肥胖正在流行,更年轻和体重更重的患者需要人工关节置换术[TJA],这些患者的疾病和并发症负担也很高,尤其是BMI超过40的患者。” “不过,肥胖是一个潜在可改变的危险因素,比如TJA之前进行减

Heart:减肥手术可降低稳定型心绞痛患者住院率!!!

由此可见,在以人群为基础的肥胖成年SAP患者研究中,患者因SAP的住院率在减肥手术后降低了三分之二。

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