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JCEM:血浆胆汁酸水平与年轻人心脏代谢危险因素相关

2021-10-27 MedSci原创 MedSci原创

血浆BA水平可能与性别有关,并且与年轻和相对健康的成年人的心脏代谢和炎症危险因素相关。

胆汁酸(BA)以其在肠道对脂质吸收的作用而闻名,并且还可以作为信号分子来控制能量代谢。先前的证据表明,循环BA水平和BA储存池的改变与肥胖风险增加和中年人T2D发病率升高相关。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,在这组表型良好且相对健康的年轻人中,研究人员旨在探究血浆BA水平与心脏代谢危险因素之间的关联。

研究人员测量了136名年轻成人(年龄为22.1±2.2岁,67%为女性)身体成分、棕色脂肪组织、血清经典心脏代谢危险因素和一组8种血浆BA(包括糖缀合物形式)。

男性血浆中CDCA和GUDCA的水平高于女性,尽管在调整体脂百分比后这些差异消失了。此外,CA、CDCA、DCA和GDCA水平与瘦体重水平呈正相关,但呈弱相关,而GDCA和GLCA水平与棕色脂肪组织对18F-氟脱氧葡萄糖的摄取呈负相关。有趣的是,GCA、GCDCA和GUDCA水平与葡萄糖和胰岛素血清水平、HOMA指数、LDL-C、TNFa、IL-2和IL-8水平呈正相关,但与HDL-C、ApoA1和脂联素水平呈负相关,然而,在将瘦体重作为混杂因素后,这些显著的相关性部分消失。

该研究的结果表明,血浆BA水平可能与性别有关,并且与年轻和相对健康的成年人的心脏代谢和炎症危险因素相关。

原始出处:

Francisco J Osuna-Prieto.et al.Plasma levels of bile acids are related to cardiometabolic risk factors in young adults.JCEM.2021.https://doi.org/10.1210/clinem/dgab773

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    2022-02-08 仁者大医
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    2022-03-01 achengzhao
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    2021-10-27 薇薇乐99

    学习了

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