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Eur radiol:乳房长肿块了?容积定量动态对比增强MRI在鉴别良恶性乳腺病变的价值

2017-10-01 shaosai MedSci原创

女性乳腺是由皮肤、纤维组织、乳腺腺体和脂肪组成的,乳腺癌是发生在乳腺腺上皮组织的恶性肿瘤。乳腺癌中99%发生在女性,男性仅占1%。乳腺癌的早期发现、早期诊断,是提高疗效的关键。应结合患者的临床表现及病史、体格检查、影像学检查、组织病理学和细胞病理学检查(在有条件的医院),进行乳腺癌的诊断与鉴别诊断。本研究旨在验证容积定量动态对比增强MRI(qDCE-MRI)在鉴别良恶性乳腺病变的价值,并将结果发表

女性乳腺是由皮肤、纤维组织、乳腺腺体和脂肪组成的,乳腺癌是发生在乳腺腺上皮组织的恶性肿瘤。乳腺癌中99%发生在女性,男性仅占1%。乳腺癌的早期发现、早期诊断,是提高疗效的关键。应结合患者的临床表现及病史、体格检查、影像学检查、组织病理学和细胞病理学检查(在有条件的医院),进行乳腺癌的诊断与鉴别诊断。本研究旨在验证容积定量动态对比增强MRI(qDCE-MRI)在鉴别良恶性乳腺病变的价值,并将结果发表在Eur radiol上。

本研究共纳入了124例患者,包括136处乳腺病变。利用二舱制扩展Tofts模型和3D感兴趣区测量定量药代动力学参数(包括K trans、K ep、V e、 V p )和半定量参数(包括TTP、MaxCon、MaxSlope、AUC)。评估形态学特点(病变大小、边界、强化方式)和时间信号强度曲线(TIC)类型。利用Logistic回归曲线验证验证恶性的预测因子,进而利用ROC曲线评估诊断效能。

结果为,qDCE参数(K trans、K ep、V p、TTP, MaxCon、MaxSlope和AUC)、形态学参数和TIC类型在良恶性病变间具有显着性差异(P≤0.001)。多变量Logistic回归分析表明K trans、K ep、MaxSlope、病变大小、边界和TIC类型是恶性的独立预测因子。基于qDCE参数的logistic模型、形态学特征结合TIC类型以及所有参数的诊断准确率分别为94.9%、89.0%、95.6%。

本研究表明,qDCE-MRI能够用来提高形态学和动力学分析鉴别乳腺病变良恶性的诊断效能。

原始出处:

Cheng Z, Wu Z, Shi G, et al,Discrimination between benign and malignant breast lesions using volumetric quantitative dynamic contrast-enhanced MR imaging. Eur Radiol. 2017.DOI: 10.1007/s00330-017-5050-2

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    2017-10-07 sunfeifeiyang

    学习

    0

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    2017-10-03 cnxcy
  3. [GetPortalCommentsPageByObjectIdResponse(id=250957, encodeId=3a5a25095e98, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sat Oct 07 00:37:11 CST 2017, time=2017-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412013, encodeId=461c1412013b4, content=<a href='/topic/show?id=951b82e63ff' target=_blank style='color:#2F92EE;'>#肿块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82763, encryptionId=951b82e63ff, topicName=肿块)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c58f2824468, createdName=cnxcy, createdTime=Tue Oct 03 02:07:00 CST 2017, time=2017-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249427, encodeId=a85824942e71, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfDEeydJz0GlP8O0ngrUX6AYCXFic0XDOOAyeQicIqnOd4TrWSwiagJrsFNYuWC1Uc6iavbS1hWt9xtZAhAqLGHqZyl/0, createdBy=42891977006, createdName=1e17414fm02(暂无匿称), createdTime=Sun Oct 01 14:08:15 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249396, encodeId=f0a124939613, content=学习了.获益匪浅!感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/17/0ed05bbc4eb124766d2a39104932ec4e.jpg, createdBy=5afd2091871, createdName=情途末路, createdTime=Sun Oct 01 11:17:39 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249394, encodeId=753c24939475, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Oct 01 11:15:57 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249393, encodeId=da4e2493939f, content= 学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Sun Oct 01 11:10:51 CST 2017, time=2017-10-01, status=1, ipAttribution=)]
    2017-10-01 1e17414fm02(暂无匿称)

    学习

    0

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    2017-10-01 情途末路

    学习了.获益匪浅!感谢分享

    0

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    2017-10-01 1e0f8808m18(暂无匿称)

    学习了.谢谢分享.

    0

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    2017-10-01 衣带渐宽

    学习

    0

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