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BBRC:低强度运动或可有助于预防精神分裂症

2020-12-27 MedSci原创 MedSci原创

目前,精神分裂症是影响人类健康的最严重疾病之一,其症状和体征复杂多样,涉及认知、思维、情感和行为等多方面的障碍以及精神活动的不协调。

目前,精神分裂症是影响人类健康的最严重疾病之一,其症状和体征复杂多样,涉及认知、思维、情感和行为等多方面的障碍以及精神活动的不协调。精神分裂症病因未明,是一种不可预防的疾病,然而对高危期人群实施有效的预防措施,减少危险因素,可能有助于降低发病率。

越来越多的证据表明,环境因素在精神分裂症的发生发展中起着重要的作用,但多变量的环境因素使得分离有益机制变得困难。为了解决这个问题,近日研究人员设计了一种新型的运动模型,将老鼠以固定的速度在跑步机上奔跑,进而评估低强度的运动对预防精神分裂症的作用。

研究人员将小鼠随机分为对照组和暴露于盐酸苯环利定(PCP)试验组,并检查了发育过程中暴露于PCP的小鼠的行为和神经功能,然后将这些小鼠在青春期进行4周的低强度运动,并进行测试以观察它们是否表现出异常行为和相关的神经系统异常。

改善了产前PCP处理的小鼠脑组织内ERK1/2磷酸化水平

研究结果令人惊讶,在发育过程中轻度运动可通过掩盖或改善因遗传而出现的神经发育异常来预防精神分裂症。这对精神分裂症的潜在神经病理学具有重要意义,特别是考虑到低强度运动可以恢复与预期行为异常相关的神经信号变化。

综上,低强度运动可以预防异常行为,这表明运动可能直接有助于预防精神分裂症。针对精神分裂症高危人群制定运动计划可能会阻止精神分裂症的发展,而可能有助于预防精神分裂症。

原始出处

Hikaru Koizumi et al. Preventive role of regular low-intensity exercise during adolescence in schizophrenia model mice with abnormal behaviorsBiochemical and Biophysical Research Communications (2020). 

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  1. [GetPortalCommentsPageByObjectIdResponse(id=914098, encodeId=1e8391409818, content=nature级别的idea,可惜了做了个bbrc水平的结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9e32216429, createdName=pendrin_89355954, createdTime=Wed Jan 06 15:11:14 CST 2021, time=2021-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912432, encodeId=8bcf9124327d, content=低强度运动可以预防异常行为,这表明运动可能直接有助于预防精神分裂症, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=724a5448132, createdName=行米巴, createdTime=Thu Dec 31 08:10:17 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404130, encodeId=bce114041303a, content=<a href='/topic/show?id=7366e6493be' target=_blank style='color:#2F92EE;'>#精神分裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76493, encryptionId=7366e6493be, topicName=精神分裂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Dec 29 11:34:58 CST 2020, time=2020-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911389, encodeId=eef6911389ee, content=低强度运动或可有助于预防精神分裂症, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 21:00:51 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911610, encodeId=95af91161056, content=适度的运动看来对各种疾病的预防都是有极大益处的。看来要把运动提上日程。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Mon Dec 28 14:20:11 CST 2020, time=2020-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911558, encodeId=e826911558f3, content=适量运动对大脑很有好处。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Dec 28 10:16:09 CST 2020, time=2020-12-28, status=1, ipAttribution=)]
    2021-01-06 pendrin_89355954

    nature级别的idea,可惜了做了个bbrc水平的结果

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=914098, encodeId=1e8391409818, content=nature级别的idea,可惜了做了个bbrc水平的结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9e32216429, createdName=pendrin_89355954, createdTime=Wed Jan 06 15:11:14 CST 2021, time=2021-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912432, encodeId=8bcf9124327d, content=低强度运动可以预防异常行为,这表明运动可能直接有助于预防精神分裂症, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=724a5448132, createdName=行米巴, createdTime=Thu Dec 31 08:10:17 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404130, encodeId=bce114041303a, content=<a href='/topic/show?id=7366e6493be' target=_blank style='color:#2F92EE;'>#精神分裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76493, encryptionId=7366e6493be, topicName=精神分裂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Dec 29 11:34:58 CST 2020, time=2020-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911389, encodeId=eef6911389ee, content=低强度运动或可有助于预防精神分裂症, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 21:00:51 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911610, encodeId=95af91161056, content=适度的运动看来对各种疾病的预防都是有极大益处的。看来要把运动提上日程。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Mon Dec 28 14:20:11 CST 2020, time=2020-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911558, encodeId=e826911558f3, content=适量运动对大脑很有好处。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Dec 28 10:16:09 CST 2020, time=2020-12-28, status=1, ipAttribution=)]
    2020-12-31 行米巴

    低强度运动可以预防异常行为,这表明运动可能直接有助于预防精神分裂症

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=914098, encodeId=1e8391409818, content=nature级别的idea,可惜了做了个bbrc水平的结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9e32216429, createdName=pendrin_89355954, createdTime=Wed Jan 06 15:11:14 CST 2021, time=2021-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912432, encodeId=8bcf9124327d, content=低强度运动可以预防异常行为,这表明运动可能直接有助于预防精神分裂症, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=724a5448132, createdName=行米巴, createdTime=Thu Dec 31 08:10:17 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404130, encodeId=bce114041303a, content=<a href='/topic/show?id=7366e6493be' target=_blank style='color:#2F92EE;'>#精神分裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76493, encryptionId=7366e6493be, topicName=精神分裂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Dec 29 11:34:58 CST 2020, time=2020-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911389, encodeId=eef6911389ee, content=低强度运动或可有助于预防精神分裂症, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 21:00:51 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911610, encodeId=95af91161056, content=适度的运动看来对各种疾病的预防都是有极大益处的。看来要把运动提上日程。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Mon Dec 28 14:20:11 CST 2020, time=2020-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911558, encodeId=e826911558f3, content=适量运动对大脑很有好处。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Dec 28 10:16:09 CST 2020, time=2020-12-28, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=914098, encodeId=1e8391409818, content=nature级别的idea,可惜了做了个bbrc水平的结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9e32216429, createdName=pendrin_89355954, createdTime=Wed Jan 06 15:11:14 CST 2021, time=2021-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912432, encodeId=8bcf9124327d, content=低强度运动可以预防异常行为,这表明运动可能直接有助于预防精神分裂症, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=724a5448132, createdName=行米巴, createdTime=Thu Dec 31 08:10:17 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404130, encodeId=bce114041303a, content=<a href='/topic/show?id=7366e6493be' target=_blank style='color:#2F92EE;'>#精神分裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76493, encryptionId=7366e6493be, topicName=精神分裂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Dec 29 11:34:58 CST 2020, time=2020-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911389, encodeId=eef6911389ee, content=低强度运动或可有助于预防精神分裂症, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 21:00:51 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911610, encodeId=95af91161056, content=适度的运动看来对各种疾病的预防都是有极大益处的。看来要把运动提上日程。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Mon Dec 28 14:20:11 CST 2020, time=2020-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911558, encodeId=e826911558f3, content=适量运动对大脑很有好处。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Dec 28 10:16:09 CST 2020, time=2020-12-28, status=1, ipAttribution=)]
    2020-12-27 oo902

    低强度运动或可有助于预防精神分裂症

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=914098, encodeId=1e8391409818, content=nature级别的idea,可惜了做了个bbrc水平的结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9e32216429, createdName=pendrin_89355954, createdTime=Wed Jan 06 15:11:14 CST 2021, time=2021-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912432, encodeId=8bcf9124327d, content=低强度运动可以预防异常行为,这表明运动可能直接有助于预防精神分裂症, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=724a5448132, createdName=行米巴, createdTime=Thu Dec 31 08:10:17 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404130, encodeId=bce114041303a, content=<a href='/topic/show?id=7366e6493be' target=_blank style='color:#2F92EE;'>#精神分裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76493, encryptionId=7366e6493be, topicName=精神分裂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Dec 29 11:34:58 CST 2020, time=2020-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911389, encodeId=eef6911389ee, content=低强度运动或可有助于预防精神分裂症, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 21:00:51 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911610, encodeId=95af91161056, content=适度的运动看来对各种疾病的预防都是有极大益处的。看来要把运动提上日程。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Mon Dec 28 14:20:11 CST 2020, time=2020-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911558, encodeId=e826911558f3, content=适量运动对大脑很有好处。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Dec 28 10:16:09 CST 2020, time=2020-12-28, status=1, ipAttribution=)]
    2020-12-28 Jessie Zhang

    适度的运动看来对各种疾病的预防都是有极大益处的。看来要把运动提上日程。

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=914098, encodeId=1e8391409818, content=nature级别的idea,可惜了做了个bbrc水平的结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9e32216429, createdName=pendrin_89355954, createdTime=Wed Jan 06 15:11:14 CST 2021, time=2021-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912432, encodeId=8bcf9124327d, content=低强度运动可以预防异常行为,这表明运动可能直接有助于预防精神分裂症, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=724a5448132, createdName=行米巴, createdTime=Thu Dec 31 08:10:17 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404130, encodeId=bce114041303a, content=<a href='/topic/show?id=7366e6493be' target=_blank style='color:#2F92EE;'>#精神分裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76493, encryptionId=7366e6493be, topicName=精神分裂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Dec 29 11:34:58 CST 2020, time=2020-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911389, encodeId=eef6911389ee, content=低强度运动或可有助于预防精神分裂症, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 21:00:51 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911610, encodeId=95af91161056, content=适度的运动看来对各种疾病的预防都是有极大益处的。看来要把运动提上日程。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Mon Dec 28 14:20:11 CST 2020, time=2020-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911558, encodeId=e826911558f3, content=适量运动对大脑很有好处。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Dec 28 10:16:09 CST 2020, time=2020-12-28, status=1, ipAttribution=)]
    2020-12-28 Jessica

    适量运动对大脑很有好处。

    0

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