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AJC:non-HDL-C是冠状动脉钙化进展的更佳预测因素

2014-04-21 寒林 译 医学论坛网

美国一项研究表明,非高密度脂蛋白胆固醇(non-HDL-C)水平,尤其是>190 mg/dl时,与动脉粥样硬化(AS)患者的冠状动脉钙化(CAC)进展风险增加相关。这个研究揭示,在血浆脂类指标中,也许非高密度脂蛋白胆固醇(non-HDL-C)水平可以作为预测AS患者CAC进展的最适因素,该研究在线发表在《美国心脏病学杂志》(Am J Cardiol)。 研究共分析了5705例AS患者,结果

美国一项研究表明,非高密度脂蛋白胆固醇(non-HDL-C)水平,尤其是>190 mg/dl时,与动脉粥样硬化(AS)患者的冠状动脉钙化(CAC)进展风险增加相关。这个研究揭示,在血浆脂类指标中,也许非高密度脂蛋白胆固醇(non-HDL-C)水平可以作为预测AS患者CAC进展的最适因素,该研究在线发表在《美国心脏病学杂志》(Am J Cardiol)。

研究共分析了5705例AS患者,结果显示,在校正年龄、性别、种族、动脉收缩压、抗高血压药物使用、吸烟、糖尿病、降脂治疗、随访时长和腰臀比后,对于基线无CAC的患者,non-HDL-C(特别是>190 mg/dl时)与CAC发生危险独立相关[相对危险(RR)=1.40,95%可信区间(CI)为1.09~1.79,P=0.008]。同样,对于基线即存在CAC的患者,non-HDL-C>190 mg/dl与CAC显著进展相关(RR=16.4,95%CI为-5.63~27.2,P=0.003)。

原始出处:


Zalawadiya SK1, Veeranna V1, Panaich S1, Kottam A1, Afonso L2.Non-high-density lipoprotein cholesterol and coronary artery calcium progression in a multiethnic US population.Am J Cardiol. 2014 Feb 1;113(3):471-4. doi: 10.1016/j.amjcard.2013.10.027. Epub 2013 Nov 9.

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    2015-02-18 lhlxtx
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    2014-04-23 ZGMFX24A
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