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AJG:糖尿病的个人病史与结肠癌的发生与大肠癌家族史一样重要

2020-07-03 MedSci原创 MedSci原创

糖尿病(DM)和大肠癌(CRC)具有一些相似的危险因素,包括生活方式和代谢紊乱。本项研究旨在探究有关CRC风险(尤其是早发性CRC)与DM的关联。

背景及目的:

糖尿病(DM)和大肠癌(CRC)具有一些相似的危险因素,包括生活方式和代谢紊乱。本项研究旨在探究有关CRC风险(尤其是早发性CRC)与DM的关联。

 

方法:

研究人员使用一项瑞典的全国性队列研究的家庭癌症数据集,进行数据分析,包括1931年以后出生的所有个体及其父母(12614256个人; 559375糖尿病患者; 162226 CRC患者)。对所有合格患者均进行了统计学分析。

 

结果:

结果显示50岁之前的DM诊断与50岁之前的CRC风险增加1.9倍相关(95%CI:1.6–2.3),而该年龄/之后年龄的CRC风险则为1.3倍(95%CI:1.2–1.4)。具有CRC家族史的患者在50岁之前进行DM诊断与50岁之前患CRC的风险是6.9倍(95%CI:4.1-12),而50岁之前或之后患CRC的风险是1.9倍(95%CI:1.4–2.5)。糖尿病患者在50岁之前有终生发生CRC的风险(0.4%,95%CI:0.3%–0.4%)。

 

讨论:

本项研究的数据表明DM与CRC风险增加相关,其程度接近于CRC家族史。DM和CRC家族史与CRC风险增加的关联在年轻人中最为明显。这些发现值得对糖尿病患者,特别是2型糖尿病患者的CRC筛查的危害,益处和成本效益进行进一步研究。

原始出处:

Ali Khan. Et al. Personal History of Diabetes as Important as Family History of Colorectal Cancer for Risk of Colorectal Cancer. The American Journal of Gastroenterology.2020.

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    2021-11-07 1482963am12暂无昵称

    学习了,谢谢

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1067952, encodeId=d74e106e952e3, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/15/7274ed1be4747d648e4e2f7f62fae403.jpg, createdBy=d8d65273314, createdName=1482963am12暂无昵称, createdTime=Sun Nov 07 22:47:57 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057311, encodeId=a297205e31161, content=<a href='/topic/show?id=18982222db' target=_blank style='color:#2F92EE;'>#AJG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2222, encryptionId=18982222db, topicName=AJG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2978132, createdName=minzju5052, createdTime=Thu Sep 03 18:14:20 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479811, encodeId=debf14e9811c6, content=<a href='/topic/show?id=fe7e4641ed7' target=_blank style='color:#2F92EE;'>#家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46417, encryptionId=fe7e4641ed7, topicName=家族史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f367584357, createdName=396094184_42047357, createdTime=Sun Jul 05 00:14:20 CST 2020, time=2020-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043198, encodeId=c3a51043198a3, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Jul 03 12:14:20 CST 2020, time=2020-07-03, status=1, ipAttribution=)]
    2020-09-03 minzju5052
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    2020-07-03 misszhang

    谢谢MedSci提供最新的资讯

    0

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