JAMA Oncol：为预防乳腺癌，女性保持体重很重要！

2015-08-16 MedSci译 MedSci原创

超过三分之二的美国女性超重或肥胖，这增加了她们绝经后患乳腺癌的风险。在女性健康倡议（WHI）临床试验延长随访后，这个二次分析调查了超重和肥胖与绝经后浸润性乳腺癌的风险的关联。 WHI的临床试验方案引入测量身高，体重，基线，一年或二年的乳房X光检查，并判定乳腺癌终点，该研究共包括了美国40个临床中心的67142例50岁至79岁的绝经后女性。这些女

超过三分之二的美国女性超重或肥胖，这增加了她们绝经后患乳腺癌的风险。在女性健康倡议（WHI）临床试验延长随访后，这个二次分析调查了超重和肥胖与绝经后浸润性乳腺癌的风险关系。

WHI的临床试验方案引入测量身高，体重，基线，一年或两年的乳房X光检查，并判定乳腺癌终点，该研究共包括了美国40个临床中心的67142例50岁至79岁的绝经后女性。这些女性从1993年到1998年被纳入此研究中，随访至2010年的中位随访时间为13年；研究人员对3388离浸润性乳腺癌病例进行了观察。

研究人员对参与者的基线测量了身高和体重，并且此后每年随访体重。关于人口特征，个人和家族病史，以及个人习惯（吸烟，体力活动）的数据进行了收集。这些女性接受了1年或2年乳房X光检查。乳腺癌是由医生评判审查病历进行核实的。

与正常体重女性相比，超重和肥胖的女性的浸润性乳腺癌的风险增加。2级加3的肥胖（身体质量指数[BMI]，由千克体重除以身高的平方计算得到，>35.0）（浸润性乳腺癌危险比（HR），1.58；95％Cl，1.40-1.79）风险最大。BMI为35.0或更高与雌激素受体阳性和孕激素受体阳性的乳腺癌风险紧密相关（HR，1.86；95％Cl，1.60-2.17），但不与雌激素受体阴性肿瘤相关。2级加3肥胖疾病进展相关，包括肿瘤体积较大（HR，2.12；95% Cl，1.67-2.69；P = 0.02），淋巴结阳性（HR，1.89；95％Cl，1.46-2.45；P=0.06），区域和/或远处的阶段（HR，1.94；95％Cl，1.52-2.47；P=0.05），以及乳腺癌后死亡（HR，2.11；95％Cl，1.57-2.84；P<0.001）。基线时BMI小于25.0的女性在随访期间体重增加超过5％的人增加患乳腺癌的风险（HR，1.36；95％Cl，1.1-1.65），但已经超重或肥胖的女性，在随访期间研究人员发现体重变化（增加或减少）与乳腺癌没有任何关联。通过绝经后激治疗对于BMI-乳腺癌的关系没有任何影响，对于从不，过去和当前使用激素治疗人群，跨BMI类别联系的方向是相似的。

肥胖增加了绝经后女性浸润性乳腺癌的风险。这些研究结果的临床意义是应该激励预防肥胖的计划。

原始出处：

Marian L. Neuhouser,Aaron K. Aragaki,Ross L. Prentice, et al.Overweight, Obesity, and Postmenopausal Invasive Breast Cancer Risk,JAMA Oncology,2015.8.11

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言

评论区 (6)

#插入话题

插入图片

[GetPortalCommentsPageByObjectIdResponse(id=1864686, encodeId=577b1864686f0, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed May 25 11:36:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35843, encodeId=b61235843ff, content=有没有亚洲的数据？, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=42fa1608766, createdName=silverscalpel, createdTime=Wed Aug 19 15:35:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35745, encodeId=0c5735e45a1, content=控制体重对心脑血管，糖尿病，肿瘤的预防都有很重要的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc1635944, createdName=DocterSunshine, createdTime=Mon Aug 17 18:40:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35730, encodeId=0b0435e3025, content=肥胖很可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Mon Aug 17 12:19:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35706, encodeId=541235e0681, content=预防肥胖, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66c61628089, createdName=caierhong, createdTime=Mon Aug 17 09:15:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35704, encodeId=d15635e0404, content=减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/11/79b7aa038ec52a741938a0243c9023e4.jpg, createdBy=7cf41618060, createdName=zhangshi908, createdTime=Mon Aug 17 06:45:00 CST 2015, time=2015-08-17, status=1, ipAttribution=)]
2016-05-25 minlingfeng

#Oncol#

71 0
[GetPortalCommentsPageByObjectIdResponse(id=1864686, encodeId=577b1864686f0, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed May 25 11:36:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35843, encodeId=b61235843ff, content=有没有亚洲的数据？, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=42fa1608766, createdName=silverscalpel, createdTime=Wed Aug 19 15:35:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35745, encodeId=0c5735e45a1, content=控制体重对心脑血管，糖尿病，肿瘤的预防都有很重要的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc1635944, createdName=DocterSunshine, createdTime=Mon Aug 17 18:40:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35730, encodeId=0b0435e3025, content=肥胖很可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Mon Aug 17 12:19:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35706, encodeId=541235e0681, content=预防肥胖, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66c61628089, createdName=caierhong, createdTime=Mon Aug 17 09:15:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35704, encodeId=d15635e0404, content=减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/11/79b7aa038ec52a741938a0243c9023e4.jpg, createdBy=7cf41618060, createdName=zhangshi908, createdTime=Mon Aug 17 06:45:00 CST 2015, time=2015-08-17, status=1, ipAttribution=)]
2015-08-19 silverscalpel

有没有亚洲的数据？

171 0
[GetPortalCommentsPageByObjectIdResponse(id=1864686, encodeId=577b1864686f0, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed May 25 11:36:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35843, encodeId=b61235843ff, content=有没有亚洲的数据？, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=42fa1608766, createdName=silverscalpel, createdTime=Wed Aug 19 15:35:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35745, encodeId=0c5735e45a1, content=控制体重对心脑血管，糖尿病，肿瘤的预防都有很重要的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc1635944, createdName=DocterSunshine, createdTime=Mon Aug 17 18:40:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35730, encodeId=0b0435e3025, content=肥胖很可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Mon Aug 17 12:19:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35706, encodeId=541235e0681, content=预防肥胖, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66c61628089, createdName=caierhong, createdTime=Mon Aug 17 09:15:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35704, encodeId=d15635e0404, content=减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/11/79b7aa038ec52a741938a0243c9023e4.jpg, createdBy=7cf41618060, createdName=zhangshi908, createdTime=Mon Aug 17 06:45:00 CST 2015, time=2015-08-17, status=1, ipAttribution=)]
2015-08-17 DocterSunshine

控制体重对心脑血管，糖尿病，肿瘤的预防都有很重要的作用

177 0
[GetPortalCommentsPageByObjectIdResponse(id=1864686, encodeId=577b1864686f0, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed May 25 11:36:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35843, encodeId=b61235843ff, content=有没有亚洲的数据？, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=42fa1608766, createdName=silverscalpel, createdTime=Wed Aug 19 15:35:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35745, encodeId=0c5735e45a1, content=控制体重对心脑血管，糖尿病，肿瘤的预防都有很重要的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc1635944, createdName=DocterSunshine, createdTime=Mon Aug 17 18:40:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35730, encodeId=0b0435e3025, content=肥胖很可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Mon Aug 17 12:19:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35706, encodeId=541235e0681, content=预防肥胖, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66c61628089, createdName=caierhong, createdTime=Mon Aug 17 09:15:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35704, encodeId=d15635e0404, content=减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/11/79b7aa038ec52a741938a0243c9023e4.jpg, createdBy=7cf41618060, createdName=zhangshi908, createdTime=Mon Aug 17 06:45:00 CST 2015, time=2015-08-17, status=1, ipAttribution=)]
2015-08-17 stupidox

肥胖很可怕

155 0
[GetPortalCommentsPageByObjectIdResponse(id=1864686, encodeId=577b1864686f0, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed May 25 11:36:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35843, encodeId=b61235843ff, content=有没有亚洲的数据？, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=42fa1608766, createdName=silverscalpel, createdTime=Wed Aug 19 15:35:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35745, encodeId=0c5735e45a1, content=控制体重对心脑血管，糖尿病，肿瘤的预防都有很重要的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc1635944, createdName=DocterSunshine, createdTime=Mon Aug 17 18:40:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35730, encodeId=0b0435e3025, content=肥胖很可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Mon Aug 17 12:19:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35706, encodeId=541235e0681, content=预防肥胖, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66c61628089, createdName=caierhong, createdTime=Mon Aug 17 09:15:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35704, encodeId=d15635e0404, content=减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/11/79b7aa038ec52a741938a0243c9023e4.jpg, createdBy=7cf41618060, createdName=zhangshi908, createdTime=Mon Aug 17 06:45:00 CST 2015, time=2015-08-17, status=1, ipAttribution=)]
2015-08-17 caierhong

预防肥胖

186 0
[GetPortalCommentsPageByObjectIdResponse(id=1864686, encodeId=577b1864686f0, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed May 25 11:36:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35843, encodeId=b61235843ff, content=有没有亚洲的数据？, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=42fa1608766, createdName=silverscalpel, createdTime=Wed Aug 19 15:35:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35745, encodeId=0c5735e45a1, content=控制体重对心脑血管，糖尿病，肿瘤的预防都有很重要的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc1635944, createdName=DocterSunshine, createdTime=Mon Aug 17 18:40:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35730, encodeId=0b0435e3025, content=肥胖很可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Mon Aug 17 12:19:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35706, encodeId=541235e0681, content=预防肥胖, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66c61628089, createdName=caierhong, createdTime=Mon Aug 17 09:15:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35704, encodeId=d15635e0404, content=减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/11/79b7aa038ec52a741938a0243c9023e4.jpg, createdBy=7cf41618060, createdName=zhangshi908, createdTime=Mon Aug 17 06:45:00 CST 2015, time=2015-08-17, status=1, ipAttribution=)]
2015-08-17 zhangshi908

减肥

181 0

内科

外科

专科科室

热点

按科室浏览

临床工具

科研工具

其他工具

科研数智化

真实世界研究解决方案

数字化学术传播解决方案

其它

肿瘤科

JAMA Oncol：为预防乳腺癌，女性保持体重很重要！

相关资讯

科室

工具

服务