Nature Cell Biology：乳腺癌对放射治疗产生耐受性的机制

2014-08-21 佚名不详

  美国德州大学MD安德森癌症中心的研究人员发现ZEB1蛋白质可帮助乳腺肿瘤细胞修复因辐射疗法带来的DNA损伤，进而可促使乳腺癌对放射疗法产生耐受性。该研究成果于2014年8月3日在线发表在《自然·细胞生物学》（Nature Cell Biology）杂志上。放射疗法可导致癌细胞DNA断裂死亡，且癌细胞DNA不能修复自身损伤，癌干细胞可通过激活细胞自身的DNA损伤反应系统来促进

美国德州大学MD安德森癌症中心的研究人员发现ZEB1蛋白质可帮助乳腺肿瘤细胞修复因辐射疗法带来的DNA损伤，进而可促使乳腺癌对放射疗法产生耐受性。该研究成果于2014年8月3日在线发表在《自然·细胞生物学》（Nature Cell Biology）杂志上。

放射疗法可导致癌细胞DNA断裂死亡，且癌细胞DNA不能修复自身损伤，癌干细胞可通过激活细胞自身的DNA损伤反应系统来促进癌细胞对放疗的耐受性，但机制不明。而在治疗乳腺癌的过程中，克服肿瘤细胞对放疗产生耐受性，揭示耐受的机制十分重要。

该研究发现ZEB1蛋白可诱发癌细胞上皮细胞间质转化（epithelial-mesenchymaltransition，EMT）过程，使其具有包括对放疗的耐受性在内的癌症干细胞的特性。EMT过程是机体对伤口愈合的一种反应，也是癌症细胞进行恶化扩散的一种方法。ZEB1蛋白可通过一系列复杂的反应使ATM基因促进蛋白质Chk1稳定表达，Chk1在DNA的损伤反应过程中扮演着重要角色，进而通过促进USP7酶的表达来提高肿瘤对放疗产生耐受性。

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2015-07-28 12498ebem31暂无昵称

#Biol#

69 0
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2014-10-04 liye789132251

#Nat#

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2015-07-23 维他命

#CEL#

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2014-09-04 sunylz

#Bio#

81 0
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2014-11-11 zhaozhouchifen

#Cell#

63 0
[GetPortalCommentsPageByObjectIdResponse(id=1766888, encodeId=ca761e6688891, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Tue Jul 28 02:21:00 CST 2015, time=2015-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1880243, encodeId=6fc9188024371, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Oct 04 23:21:00 CST 2014, time=2014-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959131, encodeId=c152195913193, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Thu Jul 23 16:21:00 CST 2015, time=2015-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917062, encodeId=ac81191e06282, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Sep 04 14:21:00 CST 2014, time=2014-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868886, encodeId=b390186888633, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Nov 11 12:21:00 CST 2014, time=2014-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417626, encodeId=cfaa141e62614, content=<a href='/topic/show?id=aada80351ae' target=_blank style='color:#2F92EE;'>#耐受性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80351, encryptionId=aada80351ae, topicName=耐受性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=43843300457, createdName=Smile2681, createdTime=Sat Aug 23 00:21:00 CST 2014, time=2014-08-23, status=1, ipAttribution=)]
2014-08-23 Smile2681

#耐受性#

51 0

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