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Am J Resp Crit Care:螨虫防渗被罩可以预防儿童哮喘加重吗?

2017-03-12 xing.T MedSci原创

由此可见,防渗被罩是减少螨虫致敏性哮喘患儿因哮喘发作而住院次数的有效手段,但并不减少需要口服泼尼松龙的患者个数。这个简单的措施可以减轻儿童哮喘恶化的医疗负担。

接触过敏原的致敏性哮喘患者与病毒之间相互作用增加哮喘发作的风险。近日,呼吸内科领域权威杂志Am J Resp Crit Care上发表了一篇研究文章,研究人员旨在评估屋尘螨虫防渗被罩对儿童重症哮喘恶化的影响。

研究人员将因哮喘发作而到医院紧急就诊的螨虫致敏的哮喘儿童(3-17岁)随机化分组,分别领取螨虫防渗层(实验)或对照(安慰剂)床套。该研究的主要指标为在12个月的干预期哮喘加重的发生情况。

研究人员纳入了434例哮喘儿童,286(平均年龄为7.7岁,65.8%为男性)例被螨致敏,284例被随机化分组(146例进入实验组;138例进入安慰剂组)。在12个月内,研究人员发现相比于安慰剂组,实验组儿童因哮喘发作加重而到医院就诊的儿童要少(36/123[29.3%] vs. 49/118,P=0.047)。在多变量分析中,相比于安慰剂组,实验组儿童到医院紧急就诊住院的风险降低了45%(风险比为0.55[95%可信区间为0.36-0.85],P=0.006)。相比于安慰剂组,实验组儿童到医院紧急就诊住院的年度发生率要低27%,但这并没有达到统计学意义(估计边际均值[95%可信区间]:实验组为0.38[0.26-0.56] vs. 安慰剂组为0.52[0.35-0.76],P=0.18)。研究人员发现因哮喘加重而使用泼尼松的风险无显著差异(风险比为0.82[0.58-1.17],P=0.28)。

由此可见,防渗被罩是减少螨虫致敏性哮喘患儿因哮喘发作而住院次数的有效手段,但并不减少需要口服泼尼松龙的患者个数。这个简单的措施可以减轻儿童哮喘恶化的医疗负担。

原始出处:

Clare S Murray, et al. Preventing Severe Asthma Exacerbations in Children: A Randomised Trial of Mite Impermeable Bedcovers. AM J RESP CRIT CARE 2017.DOI: http://dx.doi.org/10.1164/rccm.201609-1966OC

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    2017-07-02 宋威
  2. [GetPortalCommentsPageByObjectIdResponse(id=1704045, encodeId=233c1e040456e, content=<a href='/topic/show?id=ce13888e8db' target=_blank style='color:#2F92EE;'>#螨虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88878, encryptionId=ce13888e8db, topicName=螨虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e5a630645797, createdName=宋威, createdTime=Sun Jul 02 06:57:00 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181259, encodeId=a2bd181259a2, content=谢谢老师的分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170225/IMG58B132BE210D34905.jpg, createdBy=8c462026466, createdName=1e224f04m83(暂无匿称), createdTime=Sun Mar 19 23:49:26 CST 2017, time=2017-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1295939, encodeId=e34b129593981, content=<a href='/topic/show?id=5d41282361d' target=_blank style='color:#2F92EE;'>#儿童哮喘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28236, encryptionId=5d41282361d, topicName=儿童哮喘)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a885259, createdName=yourmama, createdTime=Tue Mar 14 09:57:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179454, encodeId=c7ad1e945427, content=防渗被罩是减少螨虫致敏性哮喘患儿因哮喘发作而住院次数的有效手段, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Mon Mar 13 00:32:56 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179404, encodeId=e5c51e9404df, content=防渗被罩是减少螨虫致敏性哮喘患儿因哮喘发作而住院次数的有效手段,但并不减少需要口服泼尼松龙的患者个数, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd301464769, createdName=Albert Wu, createdTime=Sun Mar 12 19:47:27 CST 2017, time=2017-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179401, encodeId=153b1e9401dd, content=过敏性鼻炎的患儿也有必要使用防渗被罩预防支气管哮喘, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Mar 12 19:19:13 CST 2017, time=2017-03-12, status=1, ipAttribution=)]
    2017-03-19 1e224f04m83(暂无匿称)

    谢谢老师的分享!

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1704045, encodeId=233c1e040456e, content=<a href='/topic/show?id=ce13888e8db' target=_blank style='color:#2F92EE;'>#螨虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88878, encryptionId=ce13888e8db, topicName=螨虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e5a630645797, createdName=宋威, createdTime=Sun Jul 02 06:57:00 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181259, encodeId=a2bd181259a2, content=谢谢老师的分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170225/IMG58B132BE210D34905.jpg, createdBy=8c462026466, createdName=1e224f04m83(暂无匿称), createdTime=Sun Mar 19 23:49:26 CST 2017, time=2017-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1295939, encodeId=e34b129593981, content=<a href='/topic/show?id=5d41282361d' target=_blank style='color:#2F92EE;'>#儿童哮喘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28236, encryptionId=5d41282361d, topicName=儿童哮喘)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a885259, createdName=yourmama, createdTime=Tue Mar 14 09:57:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179454, encodeId=c7ad1e945427, content=防渗被罩是减少螨虫致敏性哮喘患儿因哮喘发作而住院次数的有效手段, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Mon Mar 13 00:32:56 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179404, encodeId=e5c51e9404df, content=防渗被罩是减少螨虫致敏性哮喘患儿因哮喘发作而住院次数的有效手段,但并不减少需要口服泼尼松龙的患者个数, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd301464769, createdName=Albert Wu, createdTime=Sun Mar 12 19:47:27 CST 2017, time=2017-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179401, encodeId=153b1e9401dd, content=过敏性鼻炎的患儿也有必要使用防渗被罩预防支气管哮喘, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Mar 12 19:19:13 CST 2017, time=2017-03-12, status=1, ipAttribution=)]
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    2017-03-13 ann y

    防渗被罩是减少螨虫致敏性哮喘患儿因哮喘发作而住院次数的有效手段

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1704045, encodeId=233c1e040456e, content=<a href='/topic/show?id=ce13888e8db' target=_blank style='color:#2F92EE;'>#螨虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88878, encryptionId=ce13888e8db, topicName=螨虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e5a630645797, createdName=宋威, createdTime=Sun Jul 02 06:57:00 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181259, encodeId=a2bd181259a2, content=谢谢老师的分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170225/IMG58B132BE210D34905.jpg, createdBy=8c462026466, createdName=1e224f04m83(暂无匿称), createdTime=Sun Mar 19 23:49:26 CST 2017, time=2017-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1295939, encodeId=e34b129593981, content=<a href='/topic/show?id=5d41282361d' target=_blank style='color:#2F92EE;'>#儿童哮喘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28236, encryptionId=5d41282361d, topicName=儿童哮喘)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a885259, createdName=yourmama, createdTime=Tue Mar 14 09:57:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179454, encodeId=c7ad1e945427, content=防渗被罩是减少螨虫致敏性哮喘患儿因哮喘发作而住院次数的有效手段, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Mon Mar 13 00:32:56 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179404, encodeId=e5c51e9404df, content=防渗被罩是减少螨虫致敏性哮喘患儿因哮喘发作而住院次数的有效手段,但并不减少需要口服泼尼松龙的患者个数, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd301464769, createdName=Albert Wu, createdTime=Sun Mar 12 19:47:27 CST 2017, time=2017-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179401, encodeId=153b1e9401dd, content=过敏性鼻炎的患儿也有必要使用防渗被罩预防支气管哮喘, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Mar 12 19:19:13 CST 2017, time=2017-03-12, status=1, ipAttribution=)]
    2017-03-12 Albert Wu

    防渗被罩是减少螨虫致敏性哮喘患儿因哮喘发作而住院次数的有效手段,但并不减少需要口服泼尼松龙的患者个数

    0

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    2017-03-12 有备才能无患

    过敏性鼻炎的患儿也有必要使用防渗被罩预防支气管哮喘

    0

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