Hepatology：肠道菌群失调可预测NAFLD的严重度

2015-12-09 MedSci MedSci原创

法国昂热大学医院胃肠肝病科Boursier等近日完成的一项研究表明，非酒精性脂肪性肝病(NAFLD)的严重度与肠道菌群失调以及肠道菌群的代谢功能变化有关，拟杆菌属与非酒精性脂肪性肝炎(NASH)独立相关，瘤胃球菌属与显著性肝纤维化独立相关。该项研究总共纳入经活检证实的57例NAFLD患者，应用粪便标本的16S核糖体RNA基因测序，确定肠道菌群的分类组成，对肠道菌群失调与NAFLD严

法国昂热大学医院胃肠肝病科Boursier等近日完成的一项研究表明，非酒精性脂肪性肝病(NAFLD)的严重度与肠道菌群失调以及肠道菌群的代谢功能变化有关，拟杆菌属与非酒精性脂肪性肝炎(NASH)独立相关，瘤胃球菌属与显著性肝纤维化独立相关。

该项研究总共纳入经活检证实的57例NAFLD患者，应用粪便标本的16S核糖体RNA基因测序，确定肠道菌群的分类组成，对肠道菌群失调与NAFLD严重度的关联进行评估。

结果，30例患者为F0/1期肝纤维化(10例患者为NASH)，27例患者为显著性(F≥2期)肝纤维化(25例患者为NASH)。NASH和F≥2患者的拟杆菌属丰度显著增加，而普氏菌属丰度减少，F≥2患者的瘤胃球菌属丰度显著增加。多因素分析表明，拟杆菌属丰度与NASH独立相关，瘤胃球菌属丰度与F≥2纤维化独立相关。根据这两种细菌的丰度进行分层，可将NAFLD患者分为严重度不同的3个亚组。

研究者介绍道：“除了应用传统指标判断NAFLD的严重度之外，肠道菌群分析具有重要价值，可为益生元/益生菌治疗提供新的靶向。”

原始出处：

Boursier J, Mueller O, Barret M, et al. The severity of NAFLD is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota. Hepatology. 2015 Nov 24.

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2016-02-04 lvygwyt2781

#AFLD#

95 0
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2016-09-17 zhangbaojun

#严重度#

88 0
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2016-01-05 andruhn

好文章，学习了！

243 0
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2015-12-30 忠诚向上

好好学习

209 0
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2015-12-28 wzf990214

赞一个

150 0
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2015-12-26 hixiaoluo

好文章，值得看。

195 0
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2015-12-21 dhzzm

值得学习！

138 0
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2015-12-11 1249897bm37(暂无昵称)

#肠道菌#

76 0
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2015-12-11 gwc384

#EPA#

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