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Hypertension:黄体数目异常,妊娠早期血管健康成问题

2019-03-09 国际循环编辑部 国际循环

辅助生殖技术相关的临床因素可能导致子痫前期风险增加,对这些因素加以控制可改善孕产妇健康水平。近期,发表于Hypertension杂志的一篇文章对这些可控风险因素加以研究。

辅助生殖技术相关的临床因素可能导致子痫前期风险增加,对这些因素加以控制可改善孕产妇健康水平。近期,发表于Hypertension杂志的一篇文章对这些可控风险因素加以研究。

通常,血管功能障碍出现临床表现早于子痫前期。因此,研究人员对非生理激素环境进行检测,希望探明这种可变状态是否会对妊娠早期孕妇的血管健康产生影响。研究人员纳入有不孕症既往史的女性进行前瞻性队列研究,测量并比较其血压、血管内皮功能、循环内皮祖细胞数目、血脂水平、黄体(CL)激素水平。将患者按照CL个数分组,分为共3组,0个CL(程序化冷冻胚胎移植[FET],N=18)、1个CL(自然受孕[N=16]和自然循环FET [N=12])和>3个CL [体外受精N=11]。研究结果显示,与CL个数为1的女性相比,CL个数为0个或>3个的女性平均动脉压较均无显著下降(P=0.05)。与CL个数为1的女性相比,个数为0组的女性反射性充血指数更低(P=0.04)。在基线脉搏波振幅方面,CL个数>3个的女性比其他两组显著升高(P=0.01)。与自然循环FET的女性相比,CL发育受限并进行FET的女性,其反射性充血指数较低但增强指数较高(P=0.03)。CL个数为0的FET女性中,血管生成和非血管生成的循环内皮祖细胞数目均较低(P=0.01和P=0.03)。

研究人员认为,CL数目异常(个数为0或>3)的女性,其妊娠早期的血管健康状况会发生改变,这提示心血管适应情况不足并导致子痫前期风险增加。

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    2019-10-19 feather89
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    2019-03-15 衣带渐宽

    学习

    0

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    2019-03-09 王秀

    学习了,涨知识了!

    0

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