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JAHA:总胆红素对终末期肾病腹膜透析患者死亡率的预测分析!

2017-12-24 xing.T MedSci原创

由此可见,在常规腹膜透析患者中血清总胆红素水平与3年死亡率显著相关。

胆红素的抗氧化特性以及预测作用的证据越来越多。然而,目前尚不清楚血清胆红素是否对正常腹膜透析患者的预后存在影响。近日,心血管疾病领域权威杂志JAHA上针对这一问题发表了一篇研究文章。

研究人员使用台湾肾脏病登记数据系统中2005年-2012年的数据集。对常规腹膜透析患者的资料进行检索。该研究的主要观察终点为3年死亡率。该研究共纳入了3704名患者(平均年龄为53.5岁,男性占44%),根据基线血清总胆红素水平将这些患者进行分组(<0.3、0.3-0.4、0.4-0.5、0.5-0.6、>0.6mg/dL)。

研究人员发现血清总胆红素水平与年龄、高血压发病率、2型糖尿病呈线性相关。观察期结束时,平均随访2.12±1.07年,1095例(30.6%)患者死亡。血清总胆红素水平与3年死亡率呈U型关系。血清总胆红素水平为0.5-0.6mg/dL的患者3年死亡率最低(24%)。在校正年龄、性别、潜在的全身性疾病、药物和实验室差异后,血清总胆红素仍然可以独立预测3年死亡率。

由此可见,在常规腹膜透析患者中血清总胆红素水平与3年死亡率显著相关。

原始出处:

Tsung‐Lin Yang,et al. Total Bilirubin in Prognosis for Mortality in End‐Stage Renal Disease Patients on Peritoneal Dialysis Therapy.JAHA.2017. https://doi.org/10.1161/JAHA.117.007507

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time=2017-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570619, encodeId=b04715e061932, content=<a href='/topic/show?id=e53d94835a5' target=_blank style='color:#2F92EE;'>#透析患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94835, encryptionId=e53d94835a5, topicName=透析患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Mon Dec 25 23:03:00 CST 2017, time=2017-12-25, status=1, ipAttribution=)]
    2017-12-27 虈亣靌

    优质资源.共同学习

    0

  5. 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time=2017-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570619, encodeId=b04715e061932, content=<a href='/topic/show?id=e53d94835a5' target=_blank style='color:#2F92EE;'>#透析患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94835, encryptionId=e53d94835a5, topicName=透析患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Mon Dec 25 23:03:00 CST 2017, time=2017-12-25, status=1, ipAttribution=)]
    2017-12-27 chunjianf

    学习了.谢谢分享

    0

  6. 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time=2017-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570619, encodeId=b04715e061932, content=<a href='/topic/show?id=e53d94835a5' target=_blank style='color:#2F92EE;'>#透析患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94835, encryptionId=e53d94835a5, topicName=透析患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Mon Dec 25 23:03:00 CST 2017, time=2017-12-25, status=1, ipAttribution=)]
    2017-12-25 zhaohui6731
  7. 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