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Crit Care:血浆代谢组学对H1N1流感肺炎的诊断和预后如何?

2017-04-23 xing.T MedSci原创

这项研究的结果表明,H1N1肺炎可以产生一个相当不同的血浆代谢谱,并且使其在病程早期基于入院24小时内的血浆样本,将其从细菌培养阳性肺炎和ICU中机械通气的对照者中进行区分出来。

代谢组学可以作为一种工具,已被用于特定疾病的诊断和预后。近日,危重病医学领域权威杂志Critical Care上发表了一篇研究文章,本研究的目的是评估代谢组学是否可以作为一个潜在的H1N1肺炎诊断和预后工具。研究人员的假设是,代谢组学可能被用来作为H1N1流感肺炎的早期诊断和预后。

研究人员采用核磁共振光谱和气相色谱-质谱法测定了42例甲型H1N1流感肺炎、31例在ICU内进行机械通气的对照者和30名在入院时为诊断疾病而抽取血浆样本培养阳性的细菌性社区获得性肺炎患者的代谢组学。

研究人员发现从入院24 h内采取样品的血浆代谢组学结果可以用来从细菌性肺炎中区分H1N1流感肺炎,以及从H1N1流感肺炎的幸存者中区分出非幸存者。此外,代谢组学是一个高度敏感的和特异性的工具,作为H1N1流感肺炎患者90天的预后。

这项研究的结果表明,H1N1肺炎可以产生一个相当不同的血浆代谢谱,并且使其在病程早期基于入院24小时内的血浆样本,将其从细菌培养阳性肺炎和ICU中机械通气的对照者中进行区分出来。

原始出处:

Mohammad M. Banoei,et al. Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia.Critical Care.2017. https://ccforum.biomedcentral.com/articles/10.1186/s13054-017-1672-7

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    2017-06-29 周周人

    学习。

    0

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    2017-06-26 周周人

    学习。

    0

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  4. 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createdName=周周人, createdTime=Mon Jun 26 07:08:04 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819954, encodeId=11d918199544b, content=<a href='/topic/show?id=4bf410018055' target=_blank style='color:#2F92EE;'>#预后如何#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100180, encryptionId=4bf410018055, topicName=预后如何)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Thu Dec 07 20:03:00 CST 2017, time=2017-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194037, encodeId=ff8c19403eb6, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Fri May 05 08:11:24 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192869, encodeId=54ed19286971, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Tue May 02 12:24:53 CST 2017, time=2017-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191826, encodeId=5c3a19182681, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Sat Apr 29 12:52:58 CST 2017, time=2017-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191169, encodeId=26e419116910, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Thu Apr 27 17:27:56 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469525, encodeId=28871469525ea, content=<a href='/topic/show?id=d46a83e3d8' target=_blank style='color:#2F92EE;'>#H1N1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8373, encryptionId=d46a83e3d8, topicName=H1N1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5ee77038498, createdName=TZF0806, createdTime=Tue Apr 25 12:03:00 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480272, encodeId=ce4014802e260, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Tue Apr 25 12:03:00 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631370, encodeId=af2816313e0ad, content=<a href='/topic/show?id=fda383e43b' target=_blank style='color:#2F92EE;'>#H1N1流感#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8374, encryptionId=fda383e43b, topicName=H1N1流感)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0eee21750483, createdName=apoenzyme, createdTime=Tue Apr 25 12:03:00 CST 2017, time=2017-04-25, status=1, ipAttribution=)]
    2017-05-05 绛珠草小姐

    学习了,谢谢

    0

  5. 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topicList=[TopicDto(id=8373, encryptionId=d46a83e3d8, topicName=H1N1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5ee77038498, createdName=TZF0806, createdTime=Tue Apr 25 12:03:00 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480272, encodeId=ce4014802e260, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Tue Apr 25 12:03:00 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631370, encodeId=af2816313e0ad, content=<a href='/topic/show?id=fda383e43b' target=_blank style='color:#2F92EE;'>#H1N1流感#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8374, encryptionId=fda383e43b, topicName=H1N1流感)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0eee21750483, createdName=apoenzyme, createdTime=Tue Apr 25 12:03:00 CST 2017, time=2017-04-25, status=1, ipAttribution=)]
    2017-05-02 绛珠草小姐

    学习了,谢谢分享

    0

  6. 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topicList=[TopicDto(id=8373, encryptionId=d46a83e3d8, topicName=H1N1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5ee77038498, createdName=TZF0806, createdTime=Tue Apr 25 12:03:00 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480272, encodeId=ce4014802e260, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Tue Apr 25 12:03:00 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631370, encodeId=af2816313e0ad, content=<a href='/topic/show?id=fda383e43b' target=_blank style='color:#2F92EE;'>#H1N1流感#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8374, encryptionId=fda383e43b, topicName=H1N1流感)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0eee21750483, createdName=apoenzyme, createdTime=Tue Apr 25 12:03:00 CST 2017, time=2017-04-25, status=1, ipAttribution=)]
    2017-04-29 绛珠草小姐

    学习了,谢谢分享

    0

  7. 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    2017-04-27 绛珠草小姐

    学习了,谢谢分享

    0

  8. 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    2017-04-25 TZF0806
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早产是围生儿死亡的重要原因之一,发生率为5%~15%。在围生儿死亡原因中居第2位(先天性畸形居首位)。近年来由于正确判断和处理胎儿出生时复苏技术以及对早产婴的监护和治疗都有很大进步,使早产儿的死亡率和患病率均有下降,但是对于预测早产儿,做好相应准备和措施仍不可忽视。 早产的发病机理研究中,越来越多的研究着眼于孕妇宫颈阴道的代谢组学变化,这是一个新奇的研究领域。Ghartey J等人进行了一项

J Hepatol:肝性脑病患者脑脊液代谢组学研究

目的:肝性脑病(HE)是肝脏疾病和/或分流术患者的一种神经系统并发症;肝硬化患者发展为明显HE的可能性为20%左右,与最小化HE相关的轻度认知障碍发生可能性约为60%至80%。本研究通过代谢组学突出HE患者脑脊液样本中异常的代谢。方法:收集了27名对照患者(没有任何神经系统疾病)和14名HE患者的脑脊液(CSF),还收集了对照组和肝硬化(伴或不伴HE)患者的血液样本。使用液相色谱与高分辨率质谱分析

综述:代谢组学研究加快医学生物标志物的发现

生物标志物(Biomarker)是指 “一种可客观检测和评价的特性,可作为正常生物学过程、病理过程或治疗干预药理学反应的指示因子”,作为个体化医疗的“关键词”之一,寻找和发现有价值的生物标志物已经成为当前医学领域的研究热点。Biomarker的研究现状和发展趋势:第一个肿瘤标志物可追溯到1846年由H Bence-Jones所证实的本周氏蛋白(Bence Jones Protein),对多发性

AJG:代谢组学可无创诊断特发性门脉高压症

图1.本项研究创新之处 特发性门脉高压症,又名肝内型窦前阻塞性门脉高压症。其病因尚不明确,可引起门脉高压所致的一系列并发症,如食管静脉曲张破裂出血及腹水等,但通常不合并存在肝硬化或其他引起肝脏病变的疾病。因其临床表现与肝硬化相似,特发性门脉高压症常被误诊为隐源性肝硬化。目前诊断特发性门脉高压症是一种排他性诊断,需要依赖进行肝穿刺活检排除肝硬化存在的可能方可诊断。 巴西巴塞罗那IDIBAPS医学

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