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Gastroenterology :内镜下黏膜切除术后黏膜缺损边缘热消融辅助治疗有助于减少结肠大息肉患者复发风险

2018-10-10 zhangfan MedSci原创

研究认为,内镜下黏膜切除术后黏膜缺损边缘热消融辅助治疗可显著降低大结肠息肉患者复发风险

肠镜检查和息肉切除是预防直肠癌(CRC)的有效手段。内镜下黏膜切除术(EMR)是切除高风险病变的常用方法,但15-30%的EMR边缘内镜下可见微小腺瘤可能导致腺瘤复发。近日研究人员考察了热消融辅助EMR对减少黏膜边缘息肉复发的作用。

416名存在超过20mm以上的大结肠扩张性病变患者参与研究。在完成EMR病灶完全切除后,210名患者接受热消融治疗,206作为对照。5-6个月后接受结肠镜复查,主要终点为病变部分复发。

接受EMR后黏膜缺损边缘热消融的患者首次复查,结肠镜下复发比例(10/192,5.2%)明显低于对照组(37/176,21.0%)(P<.001)。热消融组与对照组相比,复发的相对危险度为0.25(95% CI,0.13-0.48。组间不良事件发生率相似。

研究认为,内镜下黏膜切除术后黏膜缺损边缘热消融辅助治疗可显著降低大结肠息肉患者复发风险。

原始出处:


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    2019-06-24 许安
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  5. 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  6. 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  7. 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  8. 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  9. 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  10. 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    2018-10-11 snowpeakxu

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