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JACC:选择性PCI后,超敏肌钙蛋白T水平可以预测死亡吗?

2016-11-28 MedSci MedSci原创

在基线hs-TnT水平升高或未升高的患者中,选择性经皮冠状动脉介入术(PCI)后高敏感性肌钙蛋白T(hs-TnT)水平升高的预后价值尚不清楚。来自德国的研究人员开展了一项研究,该研究的目的是评估选择性PCI后hs-TnT水平的预后价值是否取决于基线hs-TnT水平。这项研究包括5,626名接受选择性PCI的患者,这些患者具有基线和术后hs-TnT峰值的测量值。主要结果是3年死亡率。研究人员将患者分

在基线超敏感性肌钙蛋白T(hs-TnT水平升高或未升高的患者中,选择性经皮冠状动脉介入术(PCI)后hs-TnT水平升高的预后价值尚不清楚。

来自德国的研究人员开展了一项研究,该研究的目的是评估选择性PCI后hs-TnT水平的预后价值是否取决于基线hs-TnT水平。

这项研究包括5,626名接受选择性PCI的患者,这些患者具有基线和术后hs-TnT峰值的测量值。主要结果是3年死亡率。

研究人员将患者分为4组:
基线和术后hs-TnT水平没有升高(hs-TnT≤0.014μg/l; n=742);
基线水平未升高,但术后hs-TnT水平升高(术后峰值hs-TnT>0.014μg/l;n=2,721);
基线hs-TnT水平升高(hs-TnT>0.014μg/l),术后无进一步升高(n=516);
基线hs-TnT水平升高,术后进一步升高(n=1,647)。

共有265例死亡发生:
在基线水平和术后水平均未升高的患者发生6例死亡(1.6%);
在基线水平未升高,但术后hs-TnT水平升高的患者中发生54例死亡(3.8%);
在基线hs-TnT水平升高,术后无进一步升高的患者中发生50例死亡(16.0%);
在基线hs-TnT水平升高,术后进一步升高的患者中发生155例死亡(18.2%)(p <0.001)。

调整后,基线hs-TnT水平(风险比[HR]:1.22; 95%置信区间[CI]:1.09-1.38; p <0.001),但非术后峰值hs-TnT水平(HR:1.04; CI:0.85至1.28; p = 0.679)与死亡风险增加相关。术后峰值hs-TnT结果与基线hs-TnT水平未升高(HR:0.93; 95%CI:0.69至1.25; p = 0.653)或升高(HR:1.24; 95%CI:0.91至1.69; p = 0.165)的患者死亡率相关。

在接受选择性PCI的冠状动脉疾病患者中,与基线生物标志物相比,术后hs-TnT水平升高并没有提供更多的预后信息。

原始出处:

Gjin Ndrepepa,Roisin Colleran,Siegmund Braun,et al. High-Sensitivity Troponin T and Mortality After Elective Percutaneous Coronary Intervention. J Am Coll Cardiol. 2016;68(21):2259-2268.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1922873, encodeId=4c0a19228e300, content=<a href='/topic/show?id=78f794e800a' target=_blank style='color:#2F92EE;'>#选择性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94780, encryptionId=78f794e800a, topicName=选择性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Wed Dec 14 11:21:00 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1853600, encodeId=4b0f185360023, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Apr 08 04:21:00 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=159668, encodeId=755f15966858, content=好东西学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Fri Dec 02 12:53:43 CST 2016, time=2016-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325324, encodeId=30f613253248c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Wed Nov 30 13:21:00 CST 2016, time=2016-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569116, encodeId=01c2156911608, content=<a href='/topic/show?id=2651810889c' target=_blank style='color:#2F92EE;'>#肌钙蛋白T#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81088, encryptionId=2651810889c, topicName=肌钙蛋白T)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f7f15492758, createdName=huangdf, createdTime=Wed Nov 30 13:21:00 CST 2016, time=2016-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615443, encodeId=4a2e1615443c2, content=<a href='/topic/show?id=f2839285956' target=_blank style='color:#2F92EE;'>#超敏肌钙蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92859, encryptionId=f2839285956, topicName=超敏肌钙蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=697019636918, createdName=ms6519009802973839, createdTime=Wed Nov 30 13:21:00 CST 2016, time=2016-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158830, encodeId=57f3158830f5, content=非常棒,很有说服力!, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76491981781, createdName=1e184d7bm65(暂无匿称), createdTime=Tue Nov 29 09:58:19 CST 2016, time=2016-11-29, status=1, ipAttribution=)]
    2017-04-08 hbwxf
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    2016-12-02 thlabcde

    好东西学习了

    0

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    2016-11-29 1e184d7bm65(暂无匿称)

    非常棒,很有说服力!

    0

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