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Alzheimers Dementia:痴呆者,更容易患新冠,且和年龄无关

2021-06-16 Freeman MedSci原创

痴呆者,更容易患新冠,且和年龄无关

COVID-19大流行已经席卷全球1年多,老年人被发现特别容易受到COVID-19的影响:例如,在英国,90%与COVID有关的死亡是在60岁以上的人群中,而80岁或以上的人被发现比50至59岁的人风险高20倍。

除了其他慢性并发症,包括血管和呼吸系统疾病、高血压、糖尿病、肥胖症和癌症,痴呆症已被确定为COVID-19的一个风险因素。然而,这种关联的原因仍然不清楚。有人认为,痴呆症患者的COVID-19患病率增加,至少部分原因可能是由于生活在护理或养老院,依赖外部护理人员,和/或缺乏独立性和保持卫生/预防保健措施的能力,所有这些都会增加感染的风险。

此外,年龄是痴呆症(尤其是阿尔茨海默病[AD])发展的主要风险因素,这使得COVID-19与全因痴呆症或AD之间的关联有可能被解释为痴呆症患者平均年龄大于无痴呆症患者。最后,目前还不清楚AD和帕金森病(PD)这两种在老年人中最流行的神经退行性疾病是否与COVID-19感染或其结果特别相关,或者COVID-19与全因痴呆之间的关联是否来自其他形式的痴呆(非AD、非PD)的贡献。


藉此,巴西圣保罗大学的Ana C. Tahira等人,利用应该UKB数据,在12,863名接受COVID-19检测的英国老人探究痴呆和COVID之间的关系,其中>65岁(1814人≥80岁),1167人COVID阳性。

风险因素:包括全因痴呆,特别是AD和PD,与COVID-19阳性、严重程度(住院)和死亡的关系。为了说明年龄是一个风险因素,我们将我们的队列分为三组,包括66至74岁、75至79岁和80岁及以上的人。

结果表明,所有原因的痴呆,特别是AD,与较高的COVID-19阳性诊断和住院风险有关,与年龄无关,甚至在80岁及以上的人中,也是住院病人严重程度和死亡的有力风险因素。


他们发现,全因痴呆、阿尔茨海默氏病(AD)和帕金森病与COVID-19阳性诊断有关,而全因痴呆和阿尔茨海默病 在≥80岁的人中仍有关联。

全因痴呆、AD或PD都不是整体住院的风险因素。痴呆、AD或PD不是整体住院的风险因素,但增加了COVID-19患者的住院风险。

全因性痴呆和AD增加了COVID-19的相关的死亡,而全因性痴呆与≥80岁患者的死亡增加有独特的关系。

这个超过万人的研究的重要意义在于发现了,全因性痴呆和AD是COVID19严重程度和死亡风险因素,而且这种关联和年龄无关

原文出处:

Tahira AC, Verjovski-Almeida S, Ferreira ST. Dementia is an age-independent risk factor for severity and death in COVID-19 inpatients. Alzheimers Dement. 2021 Apr 21. doi: 10.1002/alz.12352. Epub ahead of print. PMID: 33881211.

 
 
 
 

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1779792, encodeId=3cc11e79792c2, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Sat Dec 11 05:47:08 CST 2021, time=2021-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878383, encodeId=3c3018e83835b, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Wed Oct 06 01:47:08 CST 2021, time=2021-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718016, encodeId=67ff1e1801627, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Wed Sep 22 14:47:08 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=973967, encodeId=bb629e3967b3, content=新冠也看人下毒, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Wed Jun 16 07:30:17 CST 2021, time=2021-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338509, encodeId=fc9e1338509c6, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Tue Jun 15 11:47:08 CST 2021, time=2021-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1029591, encodeId=ba5f1029591f0, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sun Jun 13 23:47:08 CST 2021, time=2021-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048804, encodeId=049910488049b, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Sun Jun 13 23:47:08 CST 2021, time=2021-06-13, status=1, ipAttribution=)]
    2021-10-06 anminleiryan
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    2021-06-16 学医无涯

    新冠也看人下毒

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1779792, encodeId=3cc11e79792c2, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Sat Dec 11 05:47:08 CST 2021, time=2021-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878383, encodeId=3c3018e83835b, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Wed Oct 06 01:47:08 CST 2021, time=2021-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718016, encodeId=67ff1e1801627, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Wed Sep 22 14:47:08 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=973967, encodeId=bb629e3967b3, content=新冠也看人下毒, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Wed Jun 16 07:30:17 CST 2021, time=2021-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338509, encodeId=fc9e1338509c6, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Tue Jun 15 11:47:08 CST 2021, time=2021-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1029591, encodeId=ba5f1029591f0, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sun Jun 13 23:47:08 CST 2021, time=2021-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048804, encodeId=049910488049b, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Sun Jun 13 23:47:08 CST 2021, time=2021-06-13, status=1, ipAttribution=)]
    2021-06-13 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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    2021-06-13 junJUN

    老年人痴呆何药可用??

    0

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