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JACC:心肌梗死后ST段抬高出现越晚,患者的长期预后越差!

2021-04-21 MedSci原创 MedSci原创

心肌梗死后ST段抬高出现越晚,患者的长期预后越差

ST段抬高型心肌梗死(STEMI)是指具有典型的缺血性胸痛,持续超过20分钟,血清心肌坏死标记物浓度升高并有动态演变,心电图具有典型的ST段抬高的一类急性心肌梗死。

迄今为止,关于ST段抬高型心肌梗死患者的基线特征、临床实践和晚期症状(症状发作12至48小时)的预后的实际数据有限。

本研究旨在调查在当代经皮冠状动脉介入治疗(PCI)时代STEMI晚期患者的真实特征

研究人员从韩国急性心肌梗死登记处-国立卫生研究院数据库的13707名患者中,筛选出了5826位在2011年至2015年症状发作48小时内被确诊为STEMI的患者,并根据症状发作时间将其分为晚期(症状发作后12至48小时确诊为STEMI; n=624)或早期(<12小时; n=5202)。主要终点是180天和3年时的全因死亡率。

早期和晚期STEMI患者的累积死亡率

晚期STEMI患者的临床预后明显比早期STEMI患者的差(180天死亡率:10.7% vs 6.8%;3年死亡率:16.2% vs 10.6%;p均<0.001)。但是,症状发作12小时后才出现ST段抬高与STEMI后死亡率增加并无相关性。

不同症状窗口期患者的干预和死亡率情况

与第一症状窗口期(<12h)相比,第二窗口期(12-24h)进行侵入性干预治疗的数量急剧减少(无初始PCI治疗率从4.9%增加至12.4%;无PCI干预率从2.3%增加至了6.6%;p均<0.001)。第二窗口期才进行干预的患者的死亡率相比第一窗口期就进行干预的患者的急剧增加(180天死亡率从6.8%增加至11.2%;3年死亡率从10.6%增加至了17.3%;p均<0.05)。

综上所述,该全国性的前瞻性研究表明,STEMI后ST段抬高表现出现早或较晚的患者接受侵入性干预治疗和死亡率呈非常明显的反比差异

原始出处:

Cho Kyung Hoon, Han Xiongyi, Ahn Joon Ho et al. Long-Term Outcomes of Patients With Late Presentation of ST-Segment Elevation Myocardial Infarction. J Am Coll Cardiol, 2021, 77: 1859-1870. https://doi.org/10.1016/j.jacc.2021.02.041

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    2021-09-04 hbwxf
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    2021-04-23 海明明

    学习

    0

  4. 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channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/202404/7c0f0744e05f40309717bd3bd8e7d180-AwOc8oY53AN8.jpg, createdBy=bd115474335, createdName=我要当大牛, createdTime=Thu Apr 22 10:12:18 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959136, encodeId=7759959136cc, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Apr 21 18:08:04 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959132, encodeId=906a9591326a, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d842497785, createdName=12490f88m04暂无昵称, createdTime=Wed Apr 21 18:00:46 CST 2021, time=2021-04-21, status=1, ipAttribution=)]
  5. 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topicName=null, topicId=null, topicList=[TopicDto(id=16862, encryptionId=f27b16862d9, topicName=ST段)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=676820671866, createdName=hyf035, createdTime=Fri Apr 23 08:37:26 CST 2021, time=2021-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959608, encodeId=143495960844, content=这对心梗的预后有很好的指导意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLyXfB3bOYOsDt885AsrYWhiaRtRdPh9aZlXugm7XErBVXusv5fJLIKWTicmjSQcOibDiaLzE2YMD44PA/132, createdBy=49f71976501, createdName=Doctoryangbai, createdTime=Thu Apr 22 23:07:41 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959303, encodeId=a821959303b9, content=为什么呢?越晚出现心肌受到的缺氧时间越长?, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/202404/7c0f0744e05f40309717bd3bd8e7d180-AwOc8oY53AN8.jpg, createdBy=bd115474335, createdName=我要当大牛, createdTime=Thu Apr 22 10:12:18 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959136, encodeId=7759959136cc, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Apr 21 18:08:04 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959132, encodeId=906a9591326a, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d842497785, createdName=12490f88m04暂无昵称, createdTime=Wed Apr 21 18:00:46 CST 2021, time=2021-04-21, status=1, ipAttribution=)]
  6. 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channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/202404/7c0f0744e05f40309717bd3bd8e7d180-AwOc8oY53AN8.jpg, createdBy=bd115474335, createdName=我要当大牛, createdTime=Thu Apr 22 10:12:18 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959136, encodeId=7759959136cc, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Apr 21 18:08:04 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959132, encodeId=906a9591326a, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d842497785, createdName=12490f88m04暂无昵称, createdTime=Wed Apr 21 18:00:46 CST 2021, time=2021-04-21, status=1, ipAttribution=)]
    2021-04-23 hyf035
  7. 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channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/202404/7c0f0744e05f40309717bd3bd8e7d180-AwOc8oY53AN8.jpg, createdBy=bd115474335, createdName=我要当大牛, createdTime=Thu Apr 22 10:12:18 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959136, encodeId=7759959136cc, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Apr 21 18:08:04 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959132, encodeId=906a9591326a, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d842497785, createdName=12490f88m04暂无昵称, createdTime=Wed Apr 21 18:00:46 CST 2021, time=2021-04-21, status=1, ipAttribution=)]
    2021-04-22 Doctoryangbai

    这对心梗的预后有很好的指导意义

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1854919, encodeId=e04618549198c, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Sep 04 07:37:26 CST 2021, time=2021-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645647, encodeId=f355164564e20, content=<a href='/topic/show?id=79d99e04630' target=_blank style='color:#2F92EE;'>#长期预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97046, encryptionId=79d99e04630, topicName=长期预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e4823226485, 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topicName=null, topicId=null, topicList=[TopicDto(id=16862, encryptionId=f27b16862d9, topicName=ST段)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=676820671866, createdName=hyf035, createdTime=Fri Apr 23 08:37:26 CST 2021, time=2021-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959608, encodeId=143495960844, content=这对心梗的预后有很好的指导意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLyXfB3bOYOsDt885AsrYWhiaRtRdPh9aZlXugm7XErBVXusv5fJLIKWTicmjSQcOibDiaLzE2YMD44PA/132, createdBy=49f71976501, createdName=Doctoryangbai, createdTime=Thu Apr 22 23:07:41 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959303, encodeId=a821959303b9, content=为什么呢?越晚出现心肌受到的缺氧时间越长?, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/202404/7c0f0744e05f40309717bd3bd8e7d180-AwOc8oY53AN8.jpg, createdBy=bd115474335, createdName=我要当大牛, createdTime=Thu Apr 22 10:12:18 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959136, encodeId=7759959136cc, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Apr 21 18:08:04 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959132, encodeId=906a9591326a, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d842497785, createdName=12490f88m04暂无昵称, createdTime=Wed Apr 21 18:00:46 CST 2021, time=2021-04-21, status=1, ipAttribution=)]
    2021-04-22 我要当大牛

    为什么呢?越晚出现心肌受到的缺氧时间越长?

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1854919, encodeId=e04618549198c, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Sep 04 07:37:26 CST 2021, time=2021-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645647, encodeId=f355164564e20, content=<a href='/topic/show?id=79d99e04630' target=_blank style='color:#2F92EE;'>#长期预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97046, encryptionId=79d99e04630, topicName=长期预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e4823226485, 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topicName=null, topicId=null, topicList=[TopicDto(id=16862, encryptionId=f27b16862d9, topicName=ST段)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=676820671866, createdName=hyf035, createdTime=Fri Apr 23 08:37:26 CST 2021, time=2021-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959608, encodeId=143495960844, content=这对心梗的预后有很好的指导意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLyXfB3bOYOsDt885AsrYWhiaRtRdPh9aZlXugm7XErBVXusv5fJLIKWTicmjSQcOibDiaLzE2YMD44PA/132, createdBy=49f71976501, createdName=Doctoryangbai, createdTime=Thu Apr 22 23:07:41 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959303, encodeId=a821959303b9, content=为什么呢?越晚出现心肌受到的缺氧时间越长?, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/202404/7c0f0744e05f40309717bd3bd8e7d180-AwOc8oY53AN8.jpg, createdBy=bd115474335, createdName=我要当大牛, createdTime=Thu Apr 22 10:12:18 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959136, encodeId=7759959136cc, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Apr 21 18:08:04 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959132, encodeId=906a9591326a, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d842497785, createdName=12490f88m04暂无昵称, createdTime=Wed Apr 21 18:00:46 CST 2021, time=2021-04-21, status=1, ipAttribution=)]
    2021-04-21 jyzxjiangqin

    好文章!

    0

  10. 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topicName=null, topicId=null, topicList=[TopicDto(id=16862, encryptionId=f27b16862d9, topicName=ST段)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=676820671866, createdName=hyf035, createdTime=Fri Apr 23 08:37:26 CST 2021, time=2021-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959608, encodeId=143495960844, content=这对心梗的预后有很好的指导意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLyXfB3bOYOsDt885AsrYWhiaRtRdPh9aZlXugm7XErBVXusv5fJLIKWTicmjSQcOibDiaLzE2YMD44PA/132, createdBy=49f71976501, createdName=Doctoryangbai, createdTime=Thu Apr 22 23:07:41 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959303, encodeId=a821959303b9, content=为什么呢?越晚出现心肌受到的缺氧时间越长?, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/202404/7c0f0744e05f40309717bd3bd8e7d180-AwOc8oY53AN8.jpg, createdBy=bd115474335, createdName=我要当大牛, createdTime=Thu Apr 22 10:12:18 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959136, encodeId=7759959136cc, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Apr 21 18:08:04 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959132, encodeId=906a9591326a, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d842497785, createdName=12490f88m04暂无昵称, createdTime=Wed Apr 21 18:00:46 CST 2021, time=2021-04-21, status=1, ipAttribution=)]
    2021-04-21 12490f88m04暂无昵称

    很好

    0

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