Baidu
map

eLife:男性个子越高,患痴呆症的风险越低

2020-02-15 小通 生物通

即使将教育程度和智力水平考虑进去,这种关联仍然存在。

即使将教育程度和智力水平考虑进去,这种关联仍然存在。

随着全球人口老龄化,痴呆症已经是一个严重的问题。据世卫组织统计,每年有近1000万人患痴呆症。了解哪些个体的痴呆症风险较高,这一点至关重要,有助于人们采取预防措施。近日一项发表在《eLife》上的研究表明,个子较高的男性在年老时罹患痴呆症的风险较低。

先前的研究表明,身高可能是痴呆症的风险因素,但是许多研究都没有考虑到可能与身高和痴呆症相关的遗传、环境及其他早期生活因素。于是,丹麦的研究人员希望探索两者的关联以及智力水平、教育程度、早期生活环境和家庭因素的影响。

通讯作者、哥本哈根大学的助理教授Terese Sara H?j J?rgensen表示:“我们想了解年轻人的身高是否与痴呆症的诊断有关,同时探讨兄弟俩的智力测验分数、教育水平和潜在的环境和遗传因素是否能够解释这种关系。”

J?rgensen及其同事分析了1939年至1959年之间出生的666,333名丹麦男性的数据,包括70,608名兄弟和7,388名双胞胎。他们发现,总共有10,599名男性在年老时患上痴呆症。

他们调整分析后表明,对于平均身高以上的男性,身高每增加6 cm,患痴呆症的风险降低10%。当研究团队考虑到智力或教育的潜在作用时,身高与痴呆症风险之间的关联仅仅略微降低。

研究人员发现,在他们研究身高不同的兄弟时,身高和痴呆症风险之间的关联同样存在,这表明遗传和家庭因素本身并不能解释为什么矮个子的男性患痴呆症的风险更大。当他们研究双胞胎的数据时也是如此,不过该组的结果尚不确定。

资深作者、哥本哈根大学的教授Merete Osler解释说:“我们研究的主要优势在于,它针对教育和智力在年轻男性痴呆症风险中的潜在作用进行了调整。教育和智力这两个因素有可能帮助人们建立认知储备,使得这一群体不容易患上痴呆症。” 所谓“认知储备”,指的是大脑即兴发挥并解决日常生活中问题的能力。

Osler表示:“总的来说,我们的结果表明,年轻男性的身高较高与年老后的痴呆症风险较低存在关联,即使我们对教育程度和智力水平进行调整,这种关联仍然存在。关于兄弟的分析证实了这一点,表明这种关联可能源于早期环境暴露,而与家庭因素无关。”

她补充说,这项研究的一个限制在于尚不确定这些结论是否可以推广到女性。之前也有一些研究是分析身高与痴呆症的关系是否存在性别差异,但大多没有定论。

原始出处:
  • Terese Sara Høj Jørgensen 
  • Gunhild Tidemann Okholm 
  • Kaare Christensen 
  •  et al. Body height in young adult men and risk of dementia later in adult life. eLife. Feb 11, 2020

    版权声明:
    本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
    在此留言
    评论区 (5)
    #插入话题
    1. [GetPortalCommentsPageByObjectIdResponse(id=1973082, encodeId=2c0319e3082da, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Fri Jul 24 17:31:00 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068613, encodeId=6935206861350, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Wed Apr 08 03:31:00 CST 2020, time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836213, encodeId=d4861836213f1, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Tue Aug 25 15:31:00 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=379251, encodeId=057a3e9251cd, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Sat Feb 15 06:47:36 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048598, encodeId=99cd104859841, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Sat Feb 15 03:31:00 CST 2020, time=2020-02-15, status=1, ipAttribution=)]
      2020-07-24 膀胱癌
    2. [GetPortalCommentsPageByObjectIdResponse(id=1973082, encodeId=2c0319e3082da, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Fri Jul 24 17:31:00 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068613, encodeId=6935206861350, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Wed Apr 08 03:31:00 CST 2020, time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836213, encodeId=d4861836213f1, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Tue Aug 25 15:31:00 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=379251, encodeId=057a3e9251cd, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Sat Feb 15 06:47:36 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048598, encodeId=99cd104859841, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Sat Feb 15 03:31:00 CST 2020, time=2020-02-15, status=1, ipAttribution=)]
      2020-04-08 clmlylxy
    3. [GetPortalCommentsPageByObjectIdResponse(id=1973082, encodeId=2c0319e3082da, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Fri Jul 24 17:31:00 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068613, encodeId=6935206861350, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Wed Apr 08 03:31:00 CST 2020, time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836213, encodeId=d4861836213f1, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Tue Aug 25 15:31:00 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=379251, encodeId=057a3e9251cd, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Sat Feb 15 06:47:36 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048598, encodeId=99cd104859841, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Sat Feb 15 03:31:00 CST 2020, time=2020-02-15, status=1, ipAttribution=)]
      2020-08-25 Boyinsh
    4. [GetPortalCommentsPageByObjectIdResponse(id=1973082, encodeId=2c0319e3082da, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Fri Jul 24 17:31:00 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068613, encodeId=6935206861350, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Wed Apr 08 03:31:00 CST 2020, time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836213, encodeId=d4861836213f1, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Tue Aug 25 15:31:00 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=379251, encodeId=057a3e9251cd, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Sat Feb 15 06:47:36 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048598, encodeId=99cd104859841, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Sat Feb 15 03:31:00 CST 2020, time=2020-02-15, status=1, ipAttribution=)]
      2020-02-15 thm112988

      0

    5. [GetPortalCommentsPageByObjectIdResponse(id=1973082, encodeId=2c0319e3082da, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Fri Jul 24 17:31:00 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068613, encodeId=6935206861350, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Wed Apr 08 03:31:00 CST 2020, time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836213, encodeId=d4861836213f1, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Tue Aug 25 15:31:00 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=379251, encodeId=057a3e9251cd, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Sat Feb 15 06:47:36 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048598, encodeId=99cd104859841, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Sat Feb 15 03:31:00 CST 2020, time=2020-02-15, status=1, ipAttribution=)]
      2020-02-15 junJUN

      老年人痴呆何药可用??

      0

    相关资讯

    Hum reprod:长得胖不如生得胖?男性出生体重过小不孕风险更高

    近日发表在《Human Reproduction》杂志上的一项新研究表明,出生时体重低的男婴长大后可能会出现不育,与正常体重出生的男性相比,其不孕风险高达55%。

    AJHG:TTC29功能异常导致男性不育

    人类男性精子鞭毛的结构或功能缺陷可导致弱精症,这是男性不育时主要的精子缺陷。在此,我们关注的是精子鞭毛(MMAF)的形态异常,这种表型也被称为“短尾”,它是导致弱精子症的最严重的精子形态缺陷之一。精子鞭毛(MMAF)的形态异常,是导致弱精症的最严重的精子形态缺陷之一,这种表型也被称为“短尾”。在既往研究中,Lores等人对167名MMAF受影响的个体进行了全外显子测序,在30%以上的研究对象中发现

    JACC:女性非ST段抬高型心梗患者不良事件发生率低于男性

    非ST段抬高型急性冠脉综合征(NSTEACS)女性患者的不良事件发生率是否高于男性仍不确定,本研究的目的旨在评估NSTEACS患者预后的性别差异。本研究共纳入分析了68730名NSTEACS患者,其中19827名(29%)为女性,相比于男性患者,女性年龄更大,且发生高血压、糖尿病、心衰和肾功能不全的风险更大。在考虑混杂因素之前,女性和男性患者的主要心血管不良事件(MACE)发生率无明显差异([HR

    祖传男性“特效药”实为三无产品,上海警方捣毁一诈骗团伙

    号称手里有祖传男性“特效药”,实际竟是网络诈骗团伙。“你好,我们是某某医疗机构医师,我们这里有一款祖传男性特效药,可以治疗各种常见男性病。”如今诈骗分子可谓是花样百出,先是冒充医疗保健机构推销“特效药”,再夸大所谓“药效”让被害人不断购买。因此,不少被害人遭受损失。近日,上海浦东警方就破获了这样一起电信网络诈骗案件。2019年12月初,浦东公安分局临港分区指挥部办案民警掌握一条线索,辖区内有居民接

    男性,双下肢浮肿,请诊断!

    男性,双下肢浮肿,请诊断!

    关键Y染色体基因功能丧失会增加男性患癌风险

    许多研究表明,男性比女性更容易患癌症,但科学界对这种差异的原因仍知之甚少。巴塞罗那全球健康研究所(ISGlobal)的研究人员进行了一项研究,发现了导致男性罹患癌症风险更高的关键生物学机制:某些Y染色体性别基因的功能丧失。

    Baidu
    map
    Baidu
    map
    Baidu
    map