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BMC Cardiovasc Disord:新研究支持中国糖尿病患者使用他汀,他汀可使死亡和心血管病风险减半

2017-07-18 许菁 中国循环杂志

香港大学学者近期报告,对于糖尿病患者的一级预防,支持低密度脂蛋白胆固醇(LDL-C)降得越低,获益越大的观点。 如果使LDL-C降至2.6 mmol/L以下,心血管病风险和全因死亡风险均降低50%以上。 研究者回顾性观察了10 104例糖尿病患者,并与对照组进行了匹配。 研究发现,与未应用他汀者相比,他汀应用者的LDL-C水平降低了1.21 mmol/L。 在中位随访50.5个月后,应用他

香港大学学者近期报告,对于糖尿病患者的一级预防,支持低密度脂蛋白胆固醇(LDL-C)降得越低,获益越大的观点。

如果使LDL-C降至2.6 mmol/L以下,心血管病风险和全因死亡风险均降低50%以上。

研究者回顾性观察了10 104例糖尿病患者,并与对照组进行了匹配。

研究发现,与未应用他汀者相比,他汀应用者的LDL-C水平降低了1.21 mmol/L。

在中位随访50.5个月后,应用他汀患者的心血管病风险降低了54%,死亡风险下降62%。

如果应用他汀使LDL-C达到<2.6 mmol/L, 则心血管病风险降低50.9%,全因死亡风险降低51.3%。

但是,研究者发现,我国合并高脂血症的糖尿病患者的他汀应用严重不足,在这些患者中,未服用他汀的患者数量是服用他汀患者数量的5倍。

研究者认为,患者有可能担忧药物对肝脏有副作用,影响了药物应用。

原始出处:

Fung CSC, Wan EYF, Chan AKC, Lam CLK. Statin use reduces cardiovascular events and all-cause mortality amongst Chinese patients with type 2 diabetes mellitus: a 5-year cohort study. BMC Cardiovasc Disord. 2017,17: 166.

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    2017-12-11 cmsvly
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    2018-01-27 quxin068
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    2018-05-10 cmj8wellington
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    2017-07-19 往日如昨

    继续学习中谢谢

    0

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    2017-07-19 往日如昨

    学习了谢谢分享

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    2017-07-18 KO229256262

    学习了,很好的研究

    0

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