Atherosclerosis：ST段抬高型心肌梗死患者LDL-C和HDL-C变化与不良心血管事件相关

2015-12-30 phylis 译 MedSci原创

重要性：研究者评估了ST段抬高型心肌梗死（STEMI）患者低密度脂蛋白（LDL-C）和高密度脂蛋白（HDL-C）对5年临床预后的关系。方法：分析130例STEMI并且存活至出院的患者。出院后，基于cWIM，变异系数和标准偏差，每两个月评估一次患者LDL-C和HDL-C的变化。主要的不良心血管事件（MACE）包括死亡，心肌梗死，卒中，未计划的血管重建，心衰入院。结果：平均随访62.4±30.5个月

重要性：研究者评估了ST段抬高型心肌梗死（STEMI）患者低密度脂蛋白（LDL-C）和高密度脂蛋白（HDL-C）对5年临床预后的关系。

方法：分析130例STEMI并且存活至出院的患者。出院后，基于cWIM，变异系数和标准偏差，每两个月评估一次患者LDL-C和HDL-C的变化。主要的不良心血管事件（MACE）包括死亡、心肌梗死、卒中、未计划的血管重建、心衰入院。

结果：平均随访62.4±30.5个月，41名患者（31.5%）发生了MACE。与非MACE组相比，MACE组LDL-C的变化（cVIM：0.23±0.11 vs. 0.19±0.08；变异系数：0.24±0.12 vs. 0.19±0；标准偏差：24.1±14.5 vs. 17.6±10）和平均随访LDL-C较大，糖尿病发病率较高。校正平均随访的胆固醇水平和糖尿病，LDL-C和HDL-C变化每增加0.01 cVIM，MACE发生的风险增加分别为3.4%（HR：1.034；95%CI：1.004，1.065）和6.8%（HR：1.068；95%CI：1.003，1.137）。将变异系数和标准偏差作为衡量胆固醇变异的结果是相似的。

结论：这是第一次报告STEMI患者LDL-C和HDL-C变化与长期MACE存在独立相关。

原文出处：

Boey E, Gay GM, et al. Visit-to-visit variability in LDL- and HDL-cholesterol is associated with adverse events after ST-segment elevation myocardial infarction: A 5-year follow-up study. Atherosclerosis. 2015 Nov 4.

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2016-05-14 12498b37m72暂无昵称

#Sclerosis#

57 0
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2016-01-09 medsic

血脂值得大家关注，

130 0
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2016-01-09 medsic

已经收藏

138 0
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2016-01-09 medsic

谢谢分享，

104 0
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2016-01-09 medsic

值得看

141 0
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2016-01-09 medsic

不错，

93 0
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2016-10-23 hukaixun

#血管事件#

50 0
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2016-01-07 xyfg98

赞一个

131 0
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2016-01-07 xyfg98

非常好

115 0
[GetPortalCommentsPageByObjectIdResponse(id=1947305, encodeId=5a91194e305a4, content=<a href='/topic/show?id=d6bc160453b' target=_blank style='color:#2F92EE;'>#Sclerosis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16045, encryptionId=d6bc160453b, topicName=Sclerosis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33b92500139, createdName=12498b37m72暂无昵称, createdTime=Sat May 14 02:32:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54947, encodeId=fd575494e5e, content=血脂值得大家关注，, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 09 21:08:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54946, encodeId=034254946f9, content=已经收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 09 21:08:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54945, encodeId=0d81549455a, content=谢谢分享，, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 09 21:08:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54944, encodeId=f09754944e1, content=值得看, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 09 21:08:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54943, encodeId=07af54943ae, content=不错，, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 09 21:07:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643392, encodeId=061b16433923a, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Sun Oct 23 14:32:00 CST 2016, time=2016-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52766, encodeId=15f052e66e8, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Thu Jan 07 17:48:00 CST 2016, time=2016-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52765, encodeId=4aef52e6532, content=非常好, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Thu Jan 07 17:48:00 CST 2016, time=2016-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51788, encodeId=496d51e8816, content=非常好的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6081676206, createdName=1de22f45m90(暂无匿称), createdTime=Mon Jan 04 16:16:00 CST 2016, time=2016-01-04, status=1, ipAttribution=)]
2016-01-04 1de22f45m90(暂无匿称)

非常好的文章

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