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处理低钾血症,学好这招

2016-08-27 李鸿政 医学界呼吸频道

钾离子(K+)是机体最重要的阳离子之一,正常人体内钾总量大概是 50 mmol/kg 体重,其中 98% 位于细胞内,细胞外液的钾仅占总体钾的 2%(大概为 60 mmol,其中约 1/4 位于血浆),正因为细胞外液的钾不多,所以在补钾时不宜过快,否则可能在段时间内造成血钾升高很多,将有性命之虞。正常人血钾3.5 ~ 5.5 mmol/L 之间。 低钾血症的临床表现  血钾浓度低于 3.5 mmo

钾离子(K+)是机体最重要的阳离子之一,正常人体内钾总量大概是 50 mmol/kg 体重,其中 98% 位于细胞内,细胞外液的钾仅占总体钾的 2%(大概为 60 mmol,其中约 1/4 位于血浆),正因为细胞外液的钾不多,所以在补钾时不宜过快,否则可能在段时间内造成血钾升高很多,将有性命之虞。正常人血钾3.5 ~ 5.5 mmol/L 之间。


低钾血症的临床表现  


血钾浓度低于 3.5 mmol/L 则表示有低钾,血钾 3.0 ~ 3.5 mmol/L 为轻度,2.5 ~ 3.0 mmol/L 为中度,2.5 mmol/L 以下为重度低钾血症。低钾血症的常见原因包括:长期进食不足、应用速尿等利尿剂、长期补液不含钾、呕吐、持续胃肠减压、大量输注葡萄糖和胰岛素等。




遇到一些意识障碍、四肢无力、呼吸肌无力的患者,不光要考虑神经内科的问题,还要考虑是否有存在低钾血症可能,查个电解质吧。


一般来说,根据病史和临床表现,可初步诊断低钾血症,确诊靠血钾具体测量值。低钾血症的患者,不要忽略了心电图(入上述)检查,但并非每个病人都有心电图改变,故不应单凭心电图异常来诊断低钾血症。


一旦患者出现频繁的早搏甚至室上速等,我们就要考虑,是否有低钾血症可能,查个血钾吧,一来可以了解情况,二来可以为等下使用胺碘酮、西地兰等做好准备。


低钾血症的治疗  


治疗主要是去除造成低钾血症的病因,然后是补充钾。根据公式来计算缺多少钾、补多少钾的应用价值不大,临床很少人会通过计算来刻板地补钾,都是先粗略判断缺钾程度,然后边补边观察,必要时每天多次查血钾,一般 3 ~ 5 天补完。


补钾两个原则:能口服尽量口服,见尿补钾。


1 g 氯化钾含有 13.4 mmol/L 钾,这是计算得出的,记住它,很有用。正常人一天钾生理需要量大约是 3 g,换成氯化钾大概是 5.6 g。


普通病房的轻度缺钾患者,应鼓励进食含钾较多的食物,比如橘子、香蕉、咖啡等,能口服的尽量口服,比如口服 10%氯化钾口服溶液 10 ml tid,一天可以补充 3 g 氯化钾,加上患者还能自己吃东西,基本上可以补回来。但钾液味道不好闻,苦涩,可以兑点橙汁之类的。缺钾稍微重点的,可以口服量大点,比如 20 ml tid(共 6 g 氯化钾)。


若患者不能口服,或者低钾血症已经造成心律失常、肢体软瘫等情况,则配合静脉补钾,静脉补钾就有很多东西要注意了。普通病房静脉补钾多是外周静脉,这对补钾的浓度和速度都有限制。长期以来,《外科学》一般建议外周静脉补钾每升液体含钾量不超过 40 mmol(相当于氯化钾 3 g),这就是不超过0.3% 的由来,并且要求输入钾量应在 20 mmol/h 以下。如果患者不宜补过多液体,那么可以相应缩小含量,比如 250ml 液体可以配 0.75 g 氯化钾(10% 氯化钾注射液 7.5ml),浓度还是 0.3%,但补钾量很少,只有 0.75g 这时候可能需要用到中心静脉泵入补钾了。


很多人奇怪,在 ICU、麻醉科等科室,都是直接用 10% 氯化钾针 30 ml + 20 ml 生理盐水泵入,这样的浓度远远超过了上述 0.3%的范围了,达到了惊人的6%!这可行吗?可行!目前认为,补钾更重要的是单位时间内进入体内的钾含量,而不是补钾液上的浓度。也就是说速度比浓度更关键。上述泵入组合中,比如速度是 10 ml/h,那么应该是 0.6g 氯化钾/h的速度,1g 氯化钾 = 13.4 mmol 钾,0.6 g 氯化钾大概就是8mmol钾,这还是显着低于《外科学》认为的输入钾量应在 20 mmol/h 以下。并没有违反原则。20 mmol 钾约为 1.5g 氯化钾,从这一点来讲,每小时泵入 1.5 g 氯化钾还是安全的,也就是说,上述组合的速度可以开到 25 ml/h,如果必要的话。


现在一般认为,静脉补钾的速度不要超过 10 ~ 20 mmol/h(0.75 ~ 1.5 g 氯化钾/小时),若静脉补钾超过 10 mmol/h,则要进行心电监护。不要以为普通病房外周静脉补氯化钾浓度 0.3%(1000 ml 液体加入 3 g 氯化钾)就是安全的,速度更重要,如果你 1 个小时内把这 1000ml 液体都打进去了,那么速度应该是 3 g 氯化钾/小时了,也就是 40 mmol 钾/h,这是超出了速度限制的。


参考文献

[1] 第八版《外科学》

[2] 第十四版《实用内科学》

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    2016-09-25 1e10c84am36(暂无匿称)

    文章很好值得关注

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  2. [GetPortalCommentsPageByObjectIdResponse(id=134825, encodeId=3ca9134825d9, content=文章很好值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 25 08:56:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=107003, encodeId=1ded10e0037b, content=讲的很祥细,临床操作方便, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b2141684904, createdName=随缘, createdTime=Mon Aug 29 22:15:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106804, encodeId=63af106804e1, content=学习啦,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Mon Aug 29 11:26:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106532, encodeId=78c2106532d6, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Aug 29 05:19:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425916, encodeId=560f1425916d6, content=<a href='/topic/show?id=0eaa263891c' target=_blank style='color:#2F92EE;'>#低钾血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26389, encryptionId=0eaa263891c, topicName=低钾血症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=311d4012257, createdName=sjq028, createdTime=Mon Aug 29 03:47:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580073, encodeId=efc515800e3e2, content=<a href='/topic/show?id=ef362638e2c' target=_blank style='color:#2F92EE;'>#低钾#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26387, encryptionId=ef362638e2c, topicName=低钾)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bb6216584476, createdName=h.y200607_23674423, createdTime=Mon Aug 29 03:47:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106515, encodeId=576610651500, content=学习了啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e291719269, createdName=大旺旺, createdTime=Sun Aug 28 23:53:00 CST 2016, time=2016-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106463, encodeId=ac0e10646366, content=学习并收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160616/IMG5762A3665DC7B3997.jpg, createdBy=df0a1649089, createdName=ys2323, createdTime=Sun Aug 28 22:40:00 CST 2016, time=2016-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106188, encodeId=1ce910618869, content=这篇资讯带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Aug 28 10:23:00 CST 2016, time=2016-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106142, encodeId=17121061420b, content=很重要,需掌握, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3bd31668701, createdName=1de07360m07(暂无匿称), createdTime=Sun Aug 28 09:31:00 CST 2016, time=2016-08-28, status=1, ipAttribution=)]
    2016-08-29 随缘

    讲的很祥细,临床操作方便

    0

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    2016-08-29 医路开来

    学习啦,谢谢分享

    0

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    2016-08-29 忠诚向上

    好好学习一下

    0

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    2016-08-28 大旺旺

    学习了啊

    0

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    2016-08-28 ys2323

    学习并收藏了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=134825, encodeId=3ca9134825d9, content=文章很好值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 25 08:56:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=107003, encodeId=1ded10e0037b, content=讲的很祥细,临床操作方便, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b2141684904, createdName=随缘, createdTime=Mon Aug 29 22:15:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106804, encodeId=63af106804e1, content=学习啦,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Mon Aug 29 11:26:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106532, encodeId=78c2106532d6, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Aug 29 05:19:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425916, encodeId=560f1425916d6, content=<a href='/topic/show?id=0eaa263891c' target=_blank style='color:#2F92EE;'>#低钾血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26389, encryptionId=0eaa263891c, topicName=低钾血症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=311d4012257, createdName=sjq028, createdTime=Mon Aug 29 03:47:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580073, encodeId=efc515800e3e2, content=<a href='/topic/show?id=ef362638e2c' target=_blank style='color:#2F92EE;'>#低钾#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26387, encryptionId=ef362638e2c, topicName=低钾)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bb6216584476, createdName=h.y200607_23674423, createdTime=Mon Aug 29 03:47:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106515, encodeId=576610651500, content=学习了啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e291719269, createdName=大旺旺, createdTime=Sun Aug 28 23:53:00 CST 2016, time=2016-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106463, encodeId=ac0e10646366, content=学习并收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160616/IMG5762A3665DC7B3997.jpg, createdBy=df0a1649089, createdName=ys2323, createdTime=Sun Aug 28 22:40:00 CST 2016, time=2016-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106188, encodeId=1ce910618869, content=这篇资讯带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Aug 28 10:23:00 CST 2016, time=2016-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106142, encodeId=17121061420b, content=很重要,需掌握, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3bd31668701, createdName=1de07360m07(暂无匿称), createdTime=Sun Aug 28 09:31:00 CST 2016, time=2016-08-28, status=1, ipAttribution=)]
    2016-08-28 李东泽

    这篇资讯带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=134825, encodeId=3ca9134825d9, content=文章很好值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 25 08:56:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=107003, encodeId=1ded10e0037b, content=讲的很祥细,临床操作方便, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b2141684904, createdName=随缘, createdTime=Mon Aug 29 22:15:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106804, encodeId=63af106804e1, content=学习啦,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Mon Aug 29 11:26:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106532, encodeId=78c2106532d6, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Aug 29 05:19:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425916, encodeId=560f1425916d6, content=<a href='/topic/show?id=0eaa263891c' target=_blank style='color:#2F92EE;'>#低钾血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26389, encryptionId=0eaa263891c, topicName=低钾血症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=311d4012257, createdName=sjq028, createdTime=Mon Aug 29 03:47:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580073, encodeId=efc515800e3e2, content=<a href='/topic/show?id=ef362638e2c' target=_blank style='color:#2F92EE;'>#低钾#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26387, encryptionId=ef362638e2c, topicName=低钾)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bb6216584476, createdName=h.y200607_23674423, createdTime=Mon Aug 29 03:47:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106515, encodeId=576610651500, content=学习了啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e291719269, createdName=大旺旺, createdTime=Sun Aug 28 23:53:00 CST 2016, time=2016-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106463, encodeId=ac0e10646366, content=学习并收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160616/IMG5762A3665DC7B3997.jpg, createdBy=df0a1649089, createdName=ys2323, createdTime=Sun Aug 28 22:40:00 CST 2016, time=2016-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106188, encodeId=1ce910618869, content=这篇资讯带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Aug 28 10:23:00 CST 2016, time=2016-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106142, encodeId=17121061420b, content=很重要,需掌握, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3bd31668701, createdName=1de07360m07(暂无匿称), createdTime=Sun Aug 28 09:31:00 CST 2016, time=2016-08-28, status=1, ipAttribution=)]
    2016-08-28 1de07360m07(暂无匿称)

    很重要,需掌握

    0

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