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JAMA:华法林可改善伴房颤的急性心梗患者预后

2014-03-07 高晓方 译 医学论坛网

瑞典一项研究表明,在伴有房颤的急性心梗患者中,华法林治疗与死亡、心梗和缺血性卒中复合转归风险降低具有相关性,并且未升高出血风险。论文3月5日在线发表于《美国医学会杂志》。 此项研究共纳入24317例血清肌酐水平已知且伴有房颤的急性心梗存活者,并且21.8%的受试者在出院时应用华法林。依据估计肾小球滤过率(eGFR)对慢性肾病分级加以归类。复合终点由死亡以及心梗或缺血性卒中再次住院组成。主要转归指

瑞典一项研究表明,在伴有房颤的急性心梗患者中,华法林治疗与死亡、心梗和缺血性卒中复合转归风险降低具有相关性,并且未升高出血风险。论文3月5日在线发表于《美国医学会杂志》。

此项研究共纳入24317例血清肌酐水平已知且伴有房颤的急性心梗存活者,并且21.8%的受试者在出院时应用华法林。依据估计肾小球滤过率(eGFR)对慢性肾病分级加以归类。复合终点由死亡以及心梗或缺血性卒中再次住院组成。主要转归指标为复合终点、出血以及二者综合。

结果显示,共有5292例患者在出院时应用华法林,其中51.7%伴有明显慢性肾病(eGFR<60 mL/min/1.73 m2)。与未应用华法林相比,在各慢性肾病分层中华法林应用均与复合终点风险降低具有相关性。在各慢性肾病分层中,华法林治疗者的出血风险出现非显著升高。华法林应用与综合转归出现风险降低具有相关性。

原始出处:

Juan Jesús Carrero, PhD(Pharm and Med)1,2; Marie Evans, MD, PhD2; Karolina Szummer, MD, PhD3; Jonas Spaak, MD, PhD4; Lars Lindhagen, PhD5; Robert Edfors, MD3; Peter Stenvinkel, MD, PhD2; Stefan H Jacobson, MD, PhD4; Tomas Jernberg, MD, PhD3.Warfarin, Kidney Dysfunction, and Outcomes Following Acute Myocardial Infarction in Patients With Atrial Fibrillation.JAMA. 2014;311(9):919-928. doi:10.1001/jama.2014.1334.

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    2014-03-09 fei666

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