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J Periodontal Res:正畸力对吸烟者健康牙周和牙周炎组织的影响

2018-10-03 MedSci MedSci原创

本研究的目的是评估正畸力对接受/未接受香烟烟雾吸入的大鼠的健康或牙周炎组织的影响。

本研究的目的是评估正畸力对接受/未接受香烟烟雾吸入的大鼠的健康或牙周炎组织的影响。

方法:将56只雄性Wistar大鼠分成两组:吸烟和不吸烟。每组分为以下亚组:对照(C),正畸牙齿移动(OTM),结扎诱导牙周炎(P)和P + OTM(POTM),每组n = 14。通过丝线结扎大鼠下颌第一磨牙以诱导牙周炎,并且使用4mm闭合的不锈钢弹簧进行正畸运动。在P诱导和OTM之前,将动物暴露于10支香烟的烟雾中8分钟,每天3次,持续60天。评估牙齿移动,骨吸收和骨密度。评估了根分叉区核因子-κB(RANK)免疫染色和RANK配体/骨保护素比率的受体活化剂。

结果:各组,即吸烟和非吸烟组之间没有显着的统计学差异(P = .338)。 P和POTM组之间的骨吸收组内分析在吸烟(P = 1)和非吸烟(P = .5)条件下无显着差异;两种情况都与OTM和C不同。关于骨密度,POTM和P与C组有显着差异(P <.05)。对于牙齿移动,POTM组与P组和C组(P = .001)有显着差异。非吸烟状态下 P和POTM组的RANK配体/骨保护素比率比非吸烟条件下C和OTM以及吸烟条件下P和POTM组更高。在吸烟条件下,P和POTM组的RANK免疫染色显着(P <.05)。

在本研究的限制范围内可以得出,即使在低水平的尼古丁、一氧化碳和焦油下,吸入的香烟烟雾对评估组也没有影响。与P组相比,POTM组没有出现更大的骨质吸收,因此牙周病对于骨质吸收至关重要。

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    2019-07-09 柳叶一刀
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    2018-10-15 wxl882001

    了解一下

    0

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    2018-10-04 grace5700
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    2018-10-03 明月清辉

    谢谢分享,学习了

    0

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    2018-10-03 飛歌

    学习了很有收获

    0

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