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Nutr Metab:老年人如何减肥?科学家发现这种减肥方法或许值得一试

2020-08-27 探索菌 生物探索

胰岛素抵抗以及内脏脂肪组织(VAT)和肌间脂肪组织(IMAT)的积聚使肥胖的老年人发生心血管疾病的风险增加。通常建议肥胖人群采取热量限制性饮食以减少脂肪量并改善代谢健康。

胰岛素抵抗以及内脏脂肪组织(VAT)和肌间脂肪组织(IMAT)的积聚使肥胖的老年人发生血管疾病的风险增加。通常建议肥胖人群采取热量限制性饮食以减少脂肪量并改善代谢健康。然而,一些研究表明,通过热量限制显著减轻体重会导致静息代谢率降低和瘦肉组织减少,这可能会导致老年人的身体机能加速下降。因此,对老年人的减肥建议仍存在争议。

对此,美国阿拉巴马大学伯明翰营养肥胖研究中心的研究人员发表的一项新研究表明,碳水化合物含量很低的饮食(VLCD)可能是促进内脏和骨骼肌脂肪流失而又不影响瘦肉组织的一种方法,并且可以改善肥胖老年人的胰岛素敏感性。随机临床试验结果表明:8周的VLCD饮食可以改善人体成分、脂肪分布和代谢健康。相关成果发表在《Nutrition & Metabolism》上。

DOI: 10.1186/s12986-020-00481-9

 

具体而言,研究人员将年龄在60-75岁之间的34名肥胖男性和女性(体重指数[BMI] 30-40 kg /m2)随机分配到VLCD饮食(碳水化合物:蛋白质:脂肪比例为<10:25:> 65%)或低脂饮食(LFD)(55:25:20)中,持续8周。在基线处和干预后,分别通过双能x线吸收法(DXA)测定人体成分,磁共振成像(MRI)测定脂肪分布,胰岛素钳夹技术测定胰岛素敏感性以及空腹抽血检测脂质。

结果显示,在VLCD和LFD之后,参与者的总脂肪分别平均减少了9.7%和2.0%(p <0.01)。而且,与LFD组相比,VLCD组的VAT损失增加了约3倍(-22.8% vs -1.0%,p <0.001),大腿IMAT下降幅度更大(-24.4%对-1.0%,p <0.01 )。调整总脂肪量后,VLCD组在8周时的大腿骨骼肌(SM)也明显增强。此外,与LFD组相比,VLCD组的胰岛素敏感性和高密度脂蛋白升高更明显,而空腹胰岛素和甘油三酸酯降低。

不同饮食组在基线时及8周后身体成分和脂肪分布结果

 

不同饮食组基线时和8周后的代谢结果

 

食用极低碳水化合物和低脂饮食后,静息能量消耗的平均变化

作者表示,餐后胰岛素分泌减少和脂肪氧化增加可以解释VLCD组的骨骼肌保存。极低的碳水化合物饮食会导致脂肪酸代谢产生的酮升高,从而集中作用降低肝葡萄糖的产生,因为从肌肉中动员的作为糖异生底物的氨基酸变少。因此,对于患有肥胖症且具有少肌症和功能障碍风险的老年人,VLCD可能是一种安全有效的减肥方法。但是,需要进一步研究以探索其可能的机制。

总结而言,这项研究证明了低碳水化合物和高脂肪饮食导致的体重减轻可能有益于肥胖的老年人,为高质量的碳水化合物vs限制脂肪饮食的临床推荐对改善肥胖老年人的身体成分和脂肪分布是否有效提供了独特的见解。

最后,小编特别提醒大家,老年人的体质已趋向衰老阶段,各器官的新陈代谢功能趋向缓慢状态,因此,老年人想要减肥,要持特别慎重的态度,应在专业人士的指导下根据自身状况合理选择药物、运动或改变饮食的方法,并密切监视身体变化,以免造成严重后果。

原始出处:Amy M Goss, Barbara Gower,  Taraneh Soleymani, et al.  Effects of weight loss during a very low carbohydrate diet on specific adipose tissue depots and insulin sensitivity in older adults with obesity: a randomized clinical trial. Nutr Metab (Lond).

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    2021-11-14 陌上咖啡

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objectType=article, channel=null, level=null, likeNumber=276, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31264, encryptionId=023031264fd, topicName=减肥), TopicDto(id=80111, encryptionId=cfef8011124, topicName=老年人)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Aug 28 00:17:37 CST 2020, time=2020-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048326, encodeId=de6b1048326df, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Aug 27 19:01:00 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814177, encodeId=acca8141e7c6, content=好资料, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ce05381686, createdName=ms4000002082197205, createdTime=Thu Aug 27 18:05:06 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814139, encodeId=fd0d814139d2, content=低碳饮食减肥比纯节食对身体的伤害小一点。<a href='/topic/show?id=212026299e2' target=_blank style='color:#2F92EE;'>#低碳饮食#</a> <a href='/topic/show?id=023031264fd' target=_blank style='color:#2F92EE;'>#减肥#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=219, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26299, encryptionId=212026299e2, topicName=低碳饮食), TopicDto(id=31264, encryptionId=023031264fd, topicName=减肥)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Aug 27 17:39:52 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814111, encodeId=113a81411188, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ce05381686, createdName=ms4000002082197205, createdTime=Thu Aug 27 17:27:54 CST 2020, time=2020-08-27, status=1, ipAttribution=)]
    2021-02-25 guojianrong
  4. 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Fri Jul 09 21:01:00 CST 2021, time=2021-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896979, encodeId=d9da8969e90b, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201105/51343dc09aad42769ab08d2a89ff603c/11727404be024d6299fc2e8e8e13ebe0.jpg, createdBy=f2715431800, createdName=ms8000000566259210, createdTime=Wed Nov 04 22:56:27 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814391, encodeId=c9cb81439186, content=<a href='/topic/show?id=023031264fd' target=_blank style='color:#2F92EE;'>#减肥#</a><a href='/topic/show?id=cfef8011124' target=_blank style='color:#2F92EE;'>#老年人#</a>低碳水化合物及高脂肪食物适合高领人群减肥 一切以健康为目的, beContent=null, 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createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Aug 27 17:39:52 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814111, encodeId=113a81411188, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ce05381686, createdName=ms4000002082197205, createdTime=Thu Aug 27 17:27:54 CST 2020, time=2020-08-27, status=1, ipAttribution=)]
    2021-07-09 一闲
  5. 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createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Aug 27 17:39:52 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814111, encodeId=113a81411188, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ce05381686, createdName=ms4000002082197205, createdTime=Thu Aug 27 17:27:54 CST 2020, time=2020-08-27, status=1, ipAttribution=)]
    2020-11-04 ms8000000566259210

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1070100, encodeId=c98710e010082, content=谢谢,有用!, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211113/7895119968f344f1b1854ae8a9ce7fad/c9580634e9e4450899057268c69ec436.jpg, createdBy=861b1485468, createdName=陌上咖啡, createdTime=Sun Nov 14 10:40:19 CST 2021, time=2021-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1802660, encodeId=91ad1802660ad, content=<a href='/topic/show?id=acfae485578' target=_blank style='color:#2F92EE;'>#科学家发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74855, encryptionId=acfae485578, topicName=科学家发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Fri 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createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Aug 27 17:39:52 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814111, encodeId=113a81411188, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ce05381686, createdName=ms4000002082197205, createdTime=Thu Aug 27 17:27:54 CST 2020, time=2020-08-27, status=1, ipAttribution=)]
    2020-08-28 zhouqu_8

    #减肥##老年人#低碳水化合物及高脂肪食物适合高领人群减肥 一切以健康为目的

    0

  7. 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    2020-08-27 CHANGE

    什么时候有懒人用的减肥神药?

    0

  8. 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    2020-08-27 ms4000002082197205

    好资料

    0

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    2020-08-27 Jessica

    低碳饮食减肥比纯节食对身体的伤害小一点。#低碳饮食# #减肥#

    0

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