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Brit J Cancer：II/III期结肠癌患者边侧性、分子亚型及治疗响应

2018-01-15 zhangfan MedSci原创

结肠癌肿瘤边侧性奥沙利铂
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研究认为，对于III期结肠癌患者，左侧肿瘤患者总生存期延长，但对于无复发生存期和奥沙利铂治疗收益的影响不显著。肿瘤分子亚型对奥沙利铂治疗收益的预测效果优于肿瘤边侧性

近日研究人员考察了II-III期结肠癌患者肿瘤边侧性与预后、分子亚型及奥沙利铂治疗敏感性之间的关系。

NSABP/NRG C-07研究包含1603名患者，考察了患者结肠癌边侧性与分子亚型、无复发生存期(RFS)以及总生存期(OS)之间的关系。

研究发现，除茎样/CMS4亚型外，边侧性与亚型相关。对于III期，左侧肿瘤患者，其总生存期延长，但对无复发生存期无显著影响。当奥沙利铂、5氟尿嘧啶与醛氢叶酸联用时，边侧性与治疗收益无关，但对于III期左侧上皮型肿瘤患者，奥沙利铂治疗的收益显著(HR=0.17， P=0.01)。

研究认为，对于III期结肠癌患者，左侧肿瘤患者总生存期延长，但对于无复发生存期和奥沙利铂治疗收益的影响不显著。肿瘤分子亚型对奥沙利铂治疗收益的预测效果优于肿瘤边侧性。

原始出处：


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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed Jan 17 07:12:10 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339934, encodeId=8fbf1339934c3, content=<a href='/topic/show?id=0ec031565c3' target=_blank style='color:#2F92EE;'>#分子亚型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31565, encryptionId=0ec031565c3, topicName=分子亚型)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Wed Jan 17 01:39:00 CST 2018, time=2018-01-17, status=1, ipAttribution=), 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    2018-03-25 juliusluan78

    #III#

    0

  2. 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    2018-02-05 方舒

    学习

    0

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    2018-01-26 大爰

    学习了谢谢分享!!

    0

  4. 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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed Jan 17 07:12:10 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339934, encodeId=8fbf1339934c3, content=<a href='/topic/show?id=0ec031565c3' target=_blank style='color:#2F92EE;'>#分子亚型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31565, encryptionId=0ec031565c3, topicName=分子亚型)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Wed Jan 17 01:39:00 CST 2018, time=2018-01-17, status=1, ipAttribution=), 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    2018-01-20 方舒

    学习

    0

  5. 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    2018-01-19 jyzxjiangqin

    结肠癌的治疗.

    0

  6. 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    2018-01-17 大爰

    学习了谢谢分享!!

    0

  7. 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GetPortalCommentsPageByObjectIdResponse(id=1594503, encodeId=8ab51594503aa, content=<a href='/topic/show?id=b317956200' target=_blank style='color:#2F92EE;'>#III期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9562, encryptionId=b317956200, topicName=III期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Wed Jan 17 01:39:00 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279198, encodeId=b5402e91984d, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Jan 16 21:04:27 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279050, encodeId=855f2e905071, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Jan 16 11:17:14 CST 2018, time=2018-01-16, status=1, ipAttribution=)]
    2018-01-17 HinsMax

    #分子亚型#

    0

  8. 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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed Jan 17 07:12:10 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339934, encodeId=8fbf1339934c3, content=<a href='/topic/show?id=0ec031565c3' target=_blank style='color:#2F92EE;'>#分子亚型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31565, encryptionId=0ec031565c3, topicName=分子亚型)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Wed Jan 17 01:39:00 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1594503, encodeId=8ab51594503aa, content=<a href='/topic/show?id=b317956200' target=_blank style='color:#2F92EE;'>#III期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9562, encryptionId=b317956200, topicName=III期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Wed Jan 17 01:39:00 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279198, encodeId=b5402e91984d, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Jan 16 21:04:27 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279050, encodeId=855f2e905071, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Jan 16 11:17:14 CST 2018, time=2018-01-16, status=1, ipAttribution=)]
    2018-01-17 智智灵药

    #III期#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1915992, encodeId=d92e191599251, content=<a href='/topic/show?id=c5a89550ff' target=_blank style='color:#2F92EE;'>#III#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9550, encryptionId=c5a89550ff, topicName=III)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e68e415, createdName=juliusluan78, createdTime=Sun Mar 25 03:39:00 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285440, encodeId=53ec28544031, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KiblTyxD95ExbzUoCVcRuhPibXboL28wicFMTXUhCA0RWCyQZYC5Na3ap7CxjialMkB50VEJ0XToQQTC/0, createdBy=470c1945776, createdName=方舒, 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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed Jan 17 07:12:10 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339934, encodeId=8fbf1339934c3, content=<a href='/topic/show?id=0ec031565c3' target=_blank style='color:#2F92EE;'>#分子亚型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31565, encryptionId=0ec031565c3, topicName=分子亚型)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Wed Jan 17 01:39:00 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1594503, encodeId=8ab51594503aa, content=<a href='/topic/show?id=b317956200' target=_blank style='color:#2F92EE;'>#III期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9562, encryptionId=b317956200, topicName=III期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Wed Jan 17 01:39:00 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279198, encodeId=b5402e91984d, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Jan 16 21:04:27 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279050, encodeId=855f2e905071, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Jan 16 11:17:14 CST 2018, time=2018-01-16, status=1, ipAttribution=)]
    2018-01-16 thlabcde

    好资料学习了!

    0

  10. 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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed Jan 17 07:12:10 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339934, encodeId=8fbf1339934c3, content=<a href='/topic/show?id=0ec031565c3' target=_blank style='color:#2F92EE;'>#分子亚型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31565, encryptionId=0ec031565c3, topicName=分子亚型)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Wed Jan 17 01:39:00 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1594503, encodeId=8ab51594503aa, content=<a href='/topic/show?id=b317956200' target=_blank style='color:#2F92EE;'>#III期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9562, encryptionId=b317956200, topicName=III期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Wed Jan 17 01:39:00 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279198, encodeId=b5402e91984d, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Jan 16 21:04:27 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279050, encodeId=855f2e905071, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Jan 16 11:17:14 CST 2018, time=2018-01-16, status=1, ipAttribution=)]
    2018-01-16 神功盖世

    阅

    0

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临床指南建议检测结肠癌术前CEA水平。术后CEA水平持续升高与肿瘤转移风险增加有关，但是术前升高术后正常的CEA水平的预后作用尚不清楚。JAMA Oncology近期发表了一篇文章，研究术前CEA水平高，术后降至正常的患者是否比术前CEA水平正常的患者复发风险更高。

Brit J Cancer：骨髓间充质细胞在低剂量辐射下可促进大肠癌细胞死亡

研究认为，骨髓间充质干细胞可强化结肠癌的放疗效果

Gastroenterology：非恶性肠道息肉手术率呈上升趋势

研究发现，在过去14年间，非恶性肠道息肉切除术得到普及且手术率显著增加

JAMA Oncology：癌胚抗原揭示结肠癌风险！

JAMA肿瘤学杂志12月21日在线发表的一项研究结果显示，结肠癌患者术前癌胚抗原（CEA）水平升高，切除后正常化的风险并不高。

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