J Rheumatol：粘膜相关恒定T细胞参与强直性脊柱炎的发病

2016-07-25 MedSci MedSci原创

来自日本内科和风湿病及免疫学组的研究人员发现粘膜相关的恒定T细胞可能在强直性脊柱炎中扮演了角色。强直性脊柱炎（AS）是以外周关节和韧带附着点慢性炎症为主要症状的疾病。肠道免疫被认为与AS发病相关，因为在AS患者中观察到明显的肠道和关节炎症并存。粘膜免疫相关恒定T细胞(MAIT)倾向于定居在肠固有层并产生炎性细胞因子如白介素-17(IL-17)和肿瘤坏死因子-α (TNF-α)，是AS的治疗

来自日本内科和风湿病及免疫学组的研究人员发现粘膜相关的恒定T细胞可能在强直性脊柱炎中扮演了角色。

强直性脊柱炎（AS）是以外周关节和韧带附着点慢性炎症为主要症状的疾病。肠道免疫被认为与AS发病相关，因为在AS患者中观察到明显的肠道和关节炎症并存。粘膜免疫相关恒定T细胞(MAIT)倾向于定居在肠固有层并产生炎性细胞因子如白介素-17(IL-17)和肿瘤坏死因子-α (TNF-α)，是AS的治疗目标。这个研究旨在调查MAIT细胞是如何参与AS的发病。

研究人员写道，"我们发现MAIT细胞在AS患中是激活的，但出现在外周血中的频率减少，尽管这次的研究表明MAIT细胞与AS发病相关。仍需进一步的研究确定MAIT细胞对疾病的发展和恶化的作用，以此更好的了解AS的发病机制。"

研究人员调查了30个AS患者和21个健康对照组中MAIT细胞出现的频率和细胞因子产物。使用流式细胞仪分析AS患者MAIT细胞激活标志物CD69。

研究发现，AS患者外周血中MAIT细胞出现的频率与健康对照组相比减少，有更高水平的MAIT细胞激活后产物白细胞介素-17，AS患者中强直性脊柱炎活动评分与MATI细胞CD69表达相关。

MedSci小编：

粘膜免疫机制未来一定会在许多自身免疫性疾病中得到应用。一般认为自身免疫性疾病是系统性疾病，实际上，很多自身免疫性疾病往往只在局部发病。虽然，我们认为这是因为一些局部的器官或组织被自身免疫误识别，但是这种学说并不解释全部！

全身系统性的免疫识别错误与局部免疫（粘膜免疫）或组织下淋巴系统的免疫紊乱（如淋巴生发中心的Tfr/Tfh平衡被打破），可能是许多自身免疫性疾病的真正的分子基础！

这篇研究还是非常初步的，还有更深入的局部机制可以进行研究！如果大家有兴趣，可以与梅斯医学一同开展相关研究！可以给我们发邮件哦，或在网站上留言呢

原始出处：

Study links specific invariant T cells to pathogenesis of ankylosing spondylitis，healio,July 22, 2016

Hayashi E, et al. Involvement of Mucosal-associated Invariant T cells in Ankylosing Spondylitis，J Rheumatol. 2016; doi:10.3899/jrheum.151133

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2017-02-07 zywlvao

#强直性#

57 0
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2016-10-11 1e10c84am36(暂无匿称)

好文章，受益

88 0
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2016-08-17 仁医06

#粘膜#

50 0
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2016-09-13 ylzr123

赞了！深度好文，深入学习。

85 0
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2016-08-26 ylzr123

好文章，值得学习，先赞一个

78 0
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2016-07-27 1249898am16暂无昵称

#脊柱炎#

58 0
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2016-07-25 明崖

学习了，强直性脊柱炎越来越多发

100 0

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