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Hypertension:高血压年轻患者存在心脏病风险

2017-05-20 MedSci MedSci原创

新的研究显示,在血压高于140的情况下,健康的年轻人更容易出现动脉硬化,从而增加中风的风险,同时也会对肾脏和大脑造成损伤。这种情况被称为孤立收缩期高血压(ISH),发生在18-49岁的人群中,他们的收缩压为140或更高(相对于120岁以下的最佳),但正常的舒张压在80左右。收缩压是血压读数的最高值,舒张压是最低值。这是在美国进行的有史以来最大的研究--观察年轻,健康ISH患者是否有心血管问题,结果

新的研究显示,在血压高于140的情况下,健康的年轻人更容易出现动脉硬化,从而增加中风的风险,同时也会对肾脏和大脑造成损伤。

这种情况被称为孤立收缩期高血压(ISH),发生在18-49岁的人群中,他们的收缩压为140或更高(相对于120岁以下的最佳),但正常的舒张压在80左右。收缩压是血压读数的最高值,舒张压是最低值。

这是在美国进行的有史以来最大的研究--观察年轻,健康ISH患者是否有心血管问题,结果表明对年轻成年人的常规治疗方法可能是错,它忽视了较高的收缩压水平。 研究作者,UT西南医学中心高血压项目主任Wanpen Vongpatanasin博士说。

UT西南医学中心心内科教授Vongpatanasin博士说:"我认为我们应该考虑对这些患者进行早治疗。我担心,若不治疗,今后会导致更多的脑和肾功能损伤,这种情况不会好转,只会变得更糟。"

尽管这种情况在老年患者中通常会进行治疗,但一些医生却避免在年轻病人身上进行治疗。他们认为更高的收缩期读数是一种与年轻人有关的反常现象,这是一种自我纠正,甚至可能是一种更坚强的心脏的标志,因为它有时出现在高中运动员身上。Vongpatanasin博士说,他是诺曼和奥黛丽·卡普兰高血压主席,以及弗雷德里克·科恩教授在UT西南部的矿物代谢肾结石专家。

Vongpatanasin博士说,这一发现很重要,因为尽管年轻人很少有心脏病和中风,但在过去20年里,美国18到39岁之间的孤立收缩期高血压发病率增加了一倍多,现在估计大约为5%。研究人员怀疑,越来越多的人可能与肥胖率的上升有关。

这项发表在《高血压》杂志上的新研究发现,主动脉僵硬的威胁不仅是真实的,而且是可见的。美国西南地区的研究人员对达拉斯心脏研究项目的2,001名参与者进行了调查,这是基于达拉斯6000多名成年人进行的一项研究。研究人员用心血管磁共振(CMR)图片来评估参与者的心脏,以评估主动脉的状况--主动脉是将氧气从心脏输送到身体的主要动脉。从心脏直接引线的主动脉部分称为近主动脉,这部分是在高收缩压的年轻个体中发现的。

下一步将是对参与达拉斯心脏研究的受试者的肾脏,大脑和心脏进行扫描,以确定主动脉硬化的影响。

达拉斯心脏研究是达拉斯的唐纳德·雷诺兹基金会心血管临床研究中心的核心部分,与哈佛和约翰·霍普金斯大学的中心一起构成美国的三大研究中心。达拉斯心脏研究是一项针对达拉斯县6,101名成人的多民族人口研究,旨在:确定新的基因、蛋白质和成像生物标志物,在预防最有效的时候,可以检测到其早期的心血管疾病。识别社会、行为和环境因素对社区的心血管风险造成影响,从而改善社区的干预措施。增进我们对心血管疾病的生物学基础的认识。

原文出处


Yuichiro Yano.et al, Hemodynamic and Mechanical Properties of the Proximal Aorta in Young and Middle-Aged Adults With Isolated Systolic Hypertension, Hypertension (2017).

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    2017-12-12 feather89
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