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一种便秘药可治慢性肾衰竭

2015-01-04 新华 新华网

日本东北大学研究小组日前宣布,治疗便秘的药物鲁比前列酮能够遏制慢性肾衰竭的发展。 研究人员让患有慢性肾功能衰竭的实验鼠服用鲁比前列酮,结果发现,与没有服用的实验鼠相比,肠液分泌增加,肾功能衰竭时出现的肠壁恶化得到了改善,肾功能衰竭的势头也受到遏制。 研究人员对实验鼠肠内的菌群进行分析后发现,肾功能衰竭的实验鼠肠道内,乳酸杆菌属和普雷沃菌属等有益细菌种类显著减少,但是,服用鲁比前列酮之后,有益细

日本东北大学研究小组日前宣布,治疗便秘的药物鲁比前列酮能够遏制慢性肾衰竭的发展。

研究人员让患有慢性肾功能衰竭实验鼠服用鲁比前列酮,结果发现,与没有服用的实验鼠相比,肠液分泌增加,肾功能衰竭时出现的肠壁恶化得到了改善,肾功能衰竭的势头也受到遏制。

研究人员对实验鼠肠内的菌群进行分析后发现,肾功能衰竭的实验鼠肠道内,乳酸杆菌属和普雷沃菌属等有益细菌种类显著减少,但是,服用鲁比前列酮之后,有益细菌减少的情况得到改善。而且,研究人员还发现血液中尿毒素物质的浓度显著降低。

研究人员指出,这说明鲁比前列酮能改善因肾功能恶化而变化的肠内环境,减轻体内尿毒素的蓄积,从而缓解病情。今后,研究小组准备开发副作用小的低容量肠溶制剂,同时研究适用人群,从而投入实用。


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  1. [GetPortalCommentsPageByObjectIdResponse(id=33767, encodeId=90d033e67b7, content=这个药厂开心了, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Wed Jul 29 11:23:00 CST 2015, time=2015-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20265, encodeId=c5ad2026558, content=AKI对心衰临床治疗意义重大,但依然需要研究检验其适用性, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 22:25:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13942, encodeId=05391394244, content=这两种药物的反应有所不同, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/27/fbd784adc68b967ee1f6d8d7192692c0.jpg, createdBy=771884322, createdName=zczcz6655, createdTime=Sat Jan 10 21:27:00 CST 2015, time=2015-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299225, encodeId=e1ca1299225e8, content=<a href='/topic/show?id=e7e882e50df' target=_blank style='color:#2F92EE;'>#肾衰竭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82750, encryptionId=e7e882e50df, topicName=肾衰竭)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad7f282, createdName=yang0210, createdTime=Tue Jan 06 04:03:00 CST 2015, time=2015-01-06, status=1, ipAttribution=)]
    2015-07-29 sundong

    这个药厂开心了

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=33767, encodeId=90d033e67b7, content=这个药厂开心了, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Wed Jul 29 11:23:00 CST 2015, time=2015-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20265, encodeId=c5ad2026558, content=AKI对心衰临床治疗意义重大,但依然需要研究检验其适用性, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 22:25:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13942, encodeId=05391394244, content=这两种药物的反应有所不同, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/27/fbd784adc68b967ee1f6d8d7192692c0.jpg, createdBy=771884322, createdName=zczcz6655, createdTime=Sat Jan 10 21:27:00 CST 2015, time=2015-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299225, encodeId=e1ca1299225e8, content=<a href='/topic/show?id=e7e882e50df' target=_blank style='color:#2F92EE;'>#肾衰竭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82750, encryptionId=e7e882e50df, topicName=肾衰竭)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad7f282, createdName=yang0210, createdTime=Tue Jan 06 04:03:00 CST 2015, time=2015-01-06, status=1, ipAttribution=)]
    2015-04-11 x35042875

    AKI对心衰临床治疗意义重大,但依然需要研究检验其适用性

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=33767, encodeId=90d033e67b7, content=这个药厂开心了, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Wed Jul 29 11:23:00 CST 2015, time=2015-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20265, encodeId=c5ad2026558, content=AKI对心衰临床治疗意义重大,但依然需要研究检验其适用性, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 22:25:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13942, encodeId=05391394244, content=这两种药物的反应有所不同, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/27/fbd784adc68b967ee1f6d8d7192692c0.jpg, createdBy=771884322, createdName=zczcz6655, createdTime=Sat Jan 10 21:27:00 CST 2015, time=2015-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299225, encodeId=e1ca1299225e8, content=<a href='/topic/show?id=e7e882e50df' target=_blank style='color:#2F92EE;'>#肾衰竭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82750, encryptionId=e7e882e50df, topicName=肾衰竭)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad7f282, createdName=yang0210, createdTime=Tue Jan 06 04:03:00 CST 2015, time=2015-01-06, status=1, ipAttribution=)]
    2015-01-10 zczcz6655

    这两种药物的反应有所不同

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=33767, encodeId=90d033e67b7, content=这个药厂开心了, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Wed Jul 29 11:23:00 CST 2015, time=2015-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20265, encodeId=c5ad2026558, content=AKI对心衰临床治疗意义重大,但依然需要研究检验其适用性, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 22:25:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13942, encodeId=05391394244, content=这两种药物的反应有所不同, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/27/fbd784adc68b967ee1f6d8d7192692c0.jpg, createdBy=771884322, createdName=zczcz6655, createdTime=Sat Jan 10 21:27:00 CST 2015, time=2015-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299225, encodeId=e1ca1299225e8, content=<a href='/topic/show?id=e7e882e50df' target=_blank style='color:#2F92EE;'>#肾衰竭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82750, encryptionId=e7e882e50df, topicName=肾衰竭)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad7f282, createdName=yang0210, createdTime=Tue Jan 06 04:03:00 CST 2015, time=2015-01-06, status=1, ipAttribution=)]
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