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Am J Clin Nutr:摄入黄酮类食物可降低女性抑郁风险

2016-07-24 Mechront 译 MedSci原创

背景和目的:饮食中黄酮类摄入对抑郁症风险的影响尚不清楚。因此研究者进行了一项前瞻性研究,评估两者间联系。方法:纳入82643名先前无抑郁症的女性(NHS 53-80岁;NHSII 36-55岁)。每2-4年通过验证的食物频率问卷收集参与者总黄酮和类黄酮(黄酮醇、黄酮、花青素、黄烷-3-醇、黄酮和原花青素等)摄入量;医生或临床医师诊断为抑郁症、抗抑郁药的使用等认定为抑郁症。Cox比例风险模型分析两者

背景和目的:饮食中黄酮类摄入对抑郁症风险的影响尚不清楚。因此研究者进行了一项前瞻性研究,评估两者间联系。

方法:纳入82643名先前无抑郁症的女性(NHS 53-80岁;NHSII 36-55岁)。每2-4年通过验证的食物频率问卷收集参与者总黄酮和类黄酮(黄酮醇、黄酮、花青素、黄烷-3-醇、黄酮和原花青素等)摄入量;医生或临床医师诊断为抑郁症、抗抑郁药的使用等认定为抑郁症。Cox比例风险模型分析两者间联系。

结果:在10年随访期间,发生了10752例抑郁。黄酮醇、黄酮和黄烷酮摄入量与抑郁之间存在负相关;摄入量最高组(五分之一)与最低组相比,多变量校正后的HR值分别为0.93 (0.88, 0.99)、0.92 (0.86, 0.98)和0.90 (0.85, 0.96),线性趋势P-trend = 0.0004-0.08。

富含类黄酮的食物为基础的分析显示,每天摄入≥2份柑橘类水果或果汁,与每周摄入<1份的人相比,HR=0.82 (95% CI: 0.74, 0.91)。

仅分析NHS队列,摄入总黄酮、聚合物和原花青素可显著降低抑郁症风险(9-12%)。分析NHS中老年参与者(基线或随访期间≥65岁),对于他们,我们将抑郁症状纳入结果定义,除了黄烷-3-醇,高摄入量的黄酮类子类可显著降低抑郁风险;黄酮和原花青素对其影响最强烈(两者HR: 0.83; 95% CI: 0.77, 0.90)。

结论:高的黄酮类化合物摄入量可能会降低抑郁症的风险,特别是对于老年妇女。但是还需要进一步的研究来证实这些关联。

原始出处:

Chang SC,et al.Dietary flavonoid intake and risk of incident depression in midlife and older women.Am J Clin Nutr. 2016 Jul 13. pii: ajcn124545. [Epub ahead of print]

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    2017-07-06 fengyi821
  4. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Aug 27 16:13:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95743, encodeId=539495e432f, content=降低抑郁, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Wed Aug 03 17:04:00 CST 2016, time=2016-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416723, encodeId=eeda1416e23cf, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Tue Jul 26 13:19:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94635, encodeId=887194635dd, content=讲的很全面, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Jul 25 21:30:00 CST 2016, time=2016-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94587, encodeId=97b29458e05, content=了解啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Jul 25 12:10:00 CST 2016, time=2016-07-25, status=1, ipAttribution=)]
    2016-09-06 李东泽

    很好,不错,以后会多学习

    0

  5. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Aug 27 16:13:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95743, encodeId=539495e432f, content=降低抑郁, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Wed Aug 03 17:04:00 CST 2016, time=2016-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416723, encodeId=eeda1416e23cf, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Jul 25 12:10:00 CST 2016, time=2016-07-25, status=1, ipAttribution=)]
    2016-08-28 ylzr123

    深度好文,值得学习,赞!

    0

  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Aug 27 16:13:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95743, encodeId=539495e432f, content=降低抑郁, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Wed Aug 03 17:04:00 CST 2016, time=2016-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416723, encodeId=eeda1416e23cf, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Jul 25 12:10:00 CST 2016, time=2016-07-25, status=1, ipAttribution=)]
    2016-08-27 ylzr123

    好文,值得学习,赞一个。

    0

  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Aug 27 16:13:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95743, encodeId=539495e432f, content=降低抑郁, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Wed Aug 03 17:04:00 CST 2016, time=2016-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416723, encodeId=eeda1416e23cf, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Jul 25 12:10:00 CST 2016, time=2016-07-25, status=1, ipAttribution=)]
    2016-08-03 oo902

    降低抑郁

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2039708, encodeId=485d2039e085b, content=<a href='/topic/show?id=d0f554991f6' target=_blank style='color:#2F92EE;'>#抑郁风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54991, encryptionId=d0f554991f6, topicName=抑郁风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Sat Jul 08 07:19:00 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822529, encodeId=326b182252937, content=<a href='/topic/show?id=ae0e103215ab' target=_blank style='color:#2F92EE;'>#黄酮类食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103215, encryptionId=ae0e103215ab, topicName=黄酮类食物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Aug 27 16:13:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95743, encodeId=539495e432f, content=降低抑郁, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Wed Aug 03 17:04:00 CST 2016, time=2016-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416723, encodeId=eeda1416e23cf, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Tue Jul 26 13:19:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94635, encodeId=887194635dd, content=讲的很全面, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Jul 25 21:30:00 CST 2016, time=2016-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94587, encodeId=97b29458e05, content=了解啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Jul 25 12:10:00 CST 2016, time=2016-07-25, status=1, ipAttribution=)]
    2016-07-26 yhy100201
  9. [GetPortalCommentsPageByObjectIdResponse(id=2039708, encodeId=485d2039e085b, content=<a href='/topic/show?id=d0f554991f6' target=_blank style='color:#2F92EE;'>#抑郁风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54991, encryptionId=d0f554991f6, topicName=抑郁风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Sat Jul 08 07:19:00 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822529, encodeId=326b182252937, content=<a href='/topic/show?id=ae0e103215ab' target=_blank style='color:#2F92EE;'>#黄酮类食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103215, encryptionId=ae0e103215ab, topicName=黄酮类食物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Aug 27 16:13:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95743, encodeId=539495e432f, content=降低抑郁, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Wed Aug 03 17:04:00 CST 2016, time=2016-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416723, encodeId=eeda1416e23cf, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Tue Jul 26 13:19:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94635, encodeId=887194635dd, content=讲的很全面, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Jul 25 21:30:00 CST 2016, time=2016-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94587, encodeId=97b29458e05, content=了解啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Jul 25 12:10:00 CST 2016, time=2016-07-25, status=1, ipAttribution=)]
    2016-07-25 oo902

    讲的很全面

    0

  10. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Aug 27 16:13:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95743, encodeId=539495e432f, content=降低抑郁, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Wed Aug 03 17:04:00 CST 2016, time=2016-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416723, encodeId=eeda1416e23cf, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Tue Jul 26 13:19:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94635, encodeId=887194635dd, content=讲的很全面, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Jul 25 21:30:00 CST 2016, time=2016-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94587, encodeId=97b29458e05, content=了解啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Jul 25 12:10:00 CST 2016, time=2016-07-25, status=1, ipAttribution=)]
    2016-07-25 1dd8c52fm63(暂无匿称)

    了解啦!

    0

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