高福院士研究组EMBO解析禽流感病毒跨物种传播机制

2015-05-07 佚名中科院

2013年6月，在台湾发现了全球首例人类感染H6N1亚型禽流感病例。从患者体内所分离的病毒基因序列显示，此病毒为一典型的低致病性禽流感病毒，与台湾本土家禽中的H6N1病毒株非常接近，其跨物种传播的分子机制成为世界科学家所关注的焦点，中国科学院微生物研究所研究员、中科院院士高福课题组在此方面的研究取得新进展，相关研究成果已于5月4日在线发表在国际杂志The EMBO Journal上。1972年以来

2013年6月，在台湾发现了全球首例人类感染H6N1亚型禽流感病例。从患者体内所分离的病毒基因序列显示，此病毒为一典型的低致病性禽流感病毒，与台湾本土家禽中的H6N1病毒株非常接近，其跨物种传播的分子机制成为世界科学家所关注的焦点，中国科学院微生物研究所研究员、中科院院士高福课题组在此方面的研究取得新进展，相关研究成果已于5月4日在线发表在国际杂志The EMBO Journal上。

1972年以来，H6N1亚型禽流感病毒感染已在台湾家禽中流行，病毒在台湾家禽之间的流行具有独特的基因谱系，不同于香港和中国大陆东南部的流行。研究人员通过分析台湾地区所有H6N1亚型流感病毒的HA蛋白中决定受体结合特性的关键性氨基酸位点变化，选取代表性毒株从蛋白和病毒水平上对其受体结合特性进行了研究，从而提出台湾地区的H6N1亚型流感病毒按其受体结合特性变化，可分为两个不同的主要时期，即早期为偏好禽源受体结合期和后期为双受体结合期，而这次人感染H6N1则偏好结合人源受体。

通过对突变体受体结合特性的研究，鉴定了其受体结合特性发生转变的关键性氨基酸位点，即186、190、228位氨基酸在H6N1亚型流感病毒的受体结合特性转变中发挥了重要的作用，E190V、G228S的突变可使H6N1亚型流感病毒获得人源受体结合能力，而P186L突变可使其偏好性结合人源受体。同时研究人员还通过结构生物学的方法从原子水平上阐明了P186L突变使得H6N1亚型流感病毒发生受体偏好性改变的结构基础。

研究人员认为目前大部分H6N1亚型的流感病毒仍保持着高水平地结合禽源受体的能力，这可能限制了其在人体内有效的复制和传播，但其对人类的生命安全还是会造成一定威胁，正如新型H7N9流感病毒一样，尤其是当H6N1亚型病毒与H9N2亚型流感病毒发生基因重组后，可能会引起新的流感大暴发。更为重要的是，这次人感染H6N1禽流感病毒偏好性结合人源受体，这表明它在受体结合特性上已与人流感病毒类似，如果加上其它的基因变异，极有可能引发大流行。

原始出处：

Wang F, Qi J, Bi Y, Zhang W, Wang M,et al.Adaptation of avian influenza A (H6N1) virus from avian to human receptor-binding preference.EMBO J. 2015 May 4. pii: e201590960.

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#插入话题

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2016-04-22 hongbochen

#解析#

76 0
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2015-07-14 respect

#跨物种#

68 0
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2016-01-16 medsic

嗯，

164 0
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2016-01-16 medsic

嗯，

137 0
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2016-01-16 medsic

过来学习下，

212 0
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2016-01-16 medsic

过来学习下，

163 0
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2015-09-07 yhj-time

#禽流感病#

76 0
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2015-05-09 venlin

#禽流感病毒#

68 0

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