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JASN:血液透析患者血清镁与髋部骨折风险之间有何关系?

2017-12-01 xing.T MedSci原创

由此可见,轻度高镁血症与血液透析患者较低的髋部骨折风险相关。

镁是一种重要的骨代谢矿物质。然而,关于镁与骨折风险之间关系的研究却鲜为人知。近日,肾脏病领域权威杂志Journal of the American Society of Nephrology上发表一篇研究文章,在这项队列研究中,研究人员旨在阐明血液透析患者血清镁水平与髋部骨折风险之间的关系。

研究人员从日本全国范围内接受血液透析的患者数据库中挑选了113683例无髋部骨折的血液透析患者。


在2年的随访中,共发生了2305例(2%)新发髋部骨折病例。粗略发病率在血清镁水平较低的四分位数患者中明显较低(Q1-Q4分别为2.63%、2.08%、1.76%和1.49%;趋势P<0.001)。各个四分位数血清镁水平范围(mg/dL)分别为:Q1<2.3;Q2,2.4-2.6;Q3,2.7-2.8以及Q4,>2.9。将人口学和临床因素进行调整后,相比于Q4患者,Q1患者发生髋部骨折的风险增加1.23倍(95%可信区间为1.06-1.44;P<0.01)。同样,逆概率加权分析显示镁水平较低的患者髋关节骨折风险增加。在亚组分析中,研究人员没有观察到显著的效应改变。髋部骨折患者血清镁水平的人群归因分数为13.7%(95%可信区间为3.7%-22.7%),其明显高于血清钙、血清磷和甲状旁腺激素水平。

由此可见,轻度高镁血症与血液透析患者较低的髋部骨折风险相关。

原始出处:

Yusuke Sakaguchi,et al. Magnesium and Risk of Hip Fracture among Patients Undergoing Hemodialysis.JASN,2017, http://jasn.asnjournals.org/content/early/2017/11/29/ASN.2017080849.abstract

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    2017-12-03 chenhongpeng
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    2017-12-03 habb
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    2017-12-03 liuquan
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    2017-12-02 131****2916

    不错的文章值得推荐

    0

  7. 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objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Fri Dec 01 23:39:42 CST 2017, time=2017-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266039, encodeId=115926603974, content=镁是一种重要的骨代谢矿物质.然而.关于镁与骨折风险之间关系的研究却鲜为人知.近日.肾脏病领域权威杂志JournaloftheAmericanSocietyofNephrology上发表一篇研究文章.在这项队列研究中.研究人员旨在阐明血液透析患者血清镁水平与髋部骨折风险之间的关系., beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri Dec 01 23:38:52 CST 2017, time=2017-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266034, encodeId=ed6c26603474, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Fri Dec 01 23:18:37 CST 2017, time=2017-12-01, status=1, ipAttribution=)]
    2017-12-02 飛歌

    学习了很有用

    0

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    2017-12-01 清风拂面

    谢谢分享.谢谢

    0

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content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sat Dec 02 22:59:18 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266060, encodeId=c8a626606068, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Dec 02 00:16:32 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266041, encodeId=7ef3266041de, content=谢谢分享.谢谢, beContent=null, 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createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri Dec 01 23:38:52 CST 2017, time=2017-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266034, encodeId=ed6c26603474, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Fri Dec 01 23:18:37 CST 2017, time=2017-12-01, status=1, ipAttribution=)]
    2017-12-01 有备才能无患

    镁是一种重要的骨代谢矿物质.然而.关于镁与骨折风险之间关系的研究却鲜为人知.近日.肾脏病领域权威杂志JournaloftheAmericanSocietyofNephrology上发表一篇研究文章.在这项队列研究中.研究人员旨在阐明血液透析患者血清镁水平与髋部骨折风险之间的关系.

    0

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    2017-12-01 131****2916

    不错的文章值得推荐

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