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J Hypertens:血压和乳腺癌的风险相关吗?

2017-06-05 xing.T MedSci原创

该研究支持了既往的研究结果表明血压与乳腺癌之间并不存在相关性。在评估血压随着时间的推移以及评估特定的肿瘤亚型时,也可以得到类似的结论。

血压与乳腺癌可能有一个共同的病理生理途径,包括慢性炎症、激素合成和代谢。以往的研究调查血压和乳腺癌之间的相关性时测量血压只是在单一的时间点,并且没有评估乳腺癌分子亚型之间的相关性。

近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,研究人员使用的数据来自于墨尔本协作队列研究的22 833名女性参与者。研究人员客观地测量了基础(1990-1994年)和随访访问(2003-2007年)的血压。研究人员采用Cox回归来估计基础血压和血压时间变化与乳腺癌整体和分子亚型风险之间相关性的风险比。

研究人员在基础测量的BP与乳腺癌整体风险之间没有观察到任何相关性(SBP每改变5 mmHg,风险比为1,95%可信区间为0.99-1.02),也与亚型无关(SBP每变化5 mmHg:雌激素受体阴性:风险比为0.99,0.96-1.03;孕激素受体阴性:风险比为1.01,0.99-1.04;人表皮生长因子受体2阴性:风险比为1,0.98-1.01)。血压随时间的变化也与乳腺癌的风险无关(SBP每改变5 mmHg,风险比为 1、0.97-1.03)。随着时间的推移增加的DBP与三种分子阴性的乳腺癌的高风险相关(P=0.04),基于少数病例(n=41)。

该研究支持了既往的研究结果表明血压与乳腺癌之间并不存在相关性。在评估血压随着时间的推移以及评估特定的肿瘤亚型时,也可以得到类似的结论。

原始出处:

Yang, Yi;et al. Blood pressure and risk of breast cancer, overall and by subtypes: a prospective cohort study.Journal of Hypertension. 2017. http://journals.lww.com/jhypertension/Abstract/2017/07000/Blood_pressure_and_risk_of_breast_cancer,_overall.9.aspx

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    2017-09-09 feather89
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    2017-06-08 ylzr123

    好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。

    0

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  4. 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    2017-06-06 cqykthl

    血压与乳腺癌风险相管性不明显

    0

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    2017-06-06 往日如昨

    学习了谢谢分享

    0

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    2017-06-06 Y—xianghai

    学习了新知识

    0

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level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Tue Jun 06 08:21:24 CST 2017, time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207176, encodeId=9c2020e176f1, content=谢谢分享。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Jun 06 08:03:56 CST 2017, time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207070, encodeId=ef5c20e07031, content=学习了分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/39b6a0099eb602e8ac1f7e10d5d440a9.jpg, createdBy=dee01724555, createdName=杨利洪, createdTime=Tue Jun 06 06:18:52 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-06 158****8818

    高血压研究领域的心进展

    0

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    2017-06-06 Julie W

    该研究支持了既往的研究结果表明血压与乳腺癌之间并不存在相关性。在评估血压随着时间的推移以及评估特定的肿瘤亚型时,也可以得到类似的结论。

    0

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    2017-06-06 doctorJiangchao

    谢谢分享。

    0

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    2017-06-06 杨利洪

    学习了分享一下

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