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Citryll融资1500万欧元开发中和中性粒细胞外陷阱(NETs)的抗体,治疗自身免疫性疾病

2019-07-06 不详 MedSci原创

荷兰生物技术公司Citryll筹集了1500万欧元(合1700万美元)的第一轮融资,以推进其针对自身免疫性疾病的新治疗方法。该公司正在开发一种基于抗体的平台,研发可用于阻止中性粒细胞胞外陷阱(NETs)形成的抗体。

荷兰生物技术公司Citryll筹集了1500万欧元(合1700万美元)的第一轮融资,以推进其针对自身免疫性疾病的新治疗方法。该公司正在开发一种基于抗体的平台,研发可用于阻止中性粒细胞胞外陷阱(NETs)形成的抗体。

NETs是细胞外纤维网络,主要由来自中性粒细胞的DNA组成,与入侵的病原体结合,是身体免疫防御的一部分,不会对宿主细胞造成损害,但在自身免疫中发挥关键作用。

在一些自身免疫性疾病如狼疮、血管炎、肺纤维化、类风湿性关节炎和脓毒症引起的器官损害中,NETs刺激自身抗原,特别是瓜氨酸化蛋白,以及炎症蛋白和有毒化合物的释放。

Citryll的首席执行官Helmuth van Es认为,干扰NETs"有可能改变游戏规则,改变预防或治疗人类疾病疗法。"

他解释说:"Citryll的方法并不广泛针对炎症或获得性免疫,而是以最安全的方式消灭自身抗原和(NET)衍生的有毒分子产生。"

原始出处:


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    2020-02-01 canlab
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    2020-01-03 wrj0121
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    2019-07-08 zhao4618
  7. [GetPortalCommentsPageByObjectIdResponse(id=1738562, encodeId=1f7d1e385627a, content=<a href='/topic/show?id=a9dd4e63c4' target=_blank style='color:#2F92EE;'>#CIT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4763, encryptionId=a9dd4e63c4, topicName=CIT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eabf34462441, createdName=12498877m109暂无昵称, createdTime=Mon Jan 13 08:32:00 CST 2020, time=2020-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734150, encodeId=c4f21e34150df, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Sat Feb 01 12:32:00 CST 2020, time=2020-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1797038, encodeId=db171e97038e6, content=<a href='/topic/show?id=ee06222067f' target=_blank style='color:#2F92EE;'>#中性粒细胞外陷阱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22206, encryptionId=ee06222067f, topicName=中性粒细胞外陷阱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c5e117, createdName=lujian, createdTime=Sun Jun 07 23:32:00 CST 2020, time=2020-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783219, encodeId=ac2e1e83219d6, content=<a href='/topic/show?id=34e54e7432' target=_blank style='color:#2F92EE;'>#Citryll#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4774, encryptionId=34e54e7432, topicName=Citryll)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d521144, createdName=wrj0121, createdTime=Fri Jan 03 08:32:00 CST 2020, time=2020-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296706, encodeId=09371296e0627, content=<a href='/topic/show?id=29c82219e47' target=_blank style='color:#2F92EE;'>#中性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22197, encryptionId=29c82219e47, topicName=中性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3883266, createdName=yykkxiaodou, createdTime=Mon Jul 08 04:32:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459075, encodeId=131814590e5ba, content=<a href='/topic/show?id=c2258886959' target=_blank style='color:#2F92EE;'>#融资#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88869, encryptionId=c2258886959, topicName=融资)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=61b96121455, createdName=zhao4618, createdTime=Mon Jul 08 04:32:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553777, encodeId=10ea1553e77db, content=<a href='/topic/show?id=5332126e5b5' target=_blank style='color:#2F92EE;'>#NETs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12675, encryptionId=5332126e5b5, topicName=NETs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a16414422875, createdName=wincls, createdTime=Mon Jul 08 04:32:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580158, encodeId=b23c158015816, content=<a href='/topic/show?id=bd2529020e1' target=_blank style='color:#2F92EE;'>#免疫性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29020, encryptionId=bd2529020e1, topicName=免疫性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df0516593209, createdName=124988c7m100暂无昵称, createdTime=Mon Jul 08 04:32:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048117, encodeId=642e104811e1b, content=又是钱!医学需要投资呀,赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Jul 06 16:32:00 CST 2019, time=2019-07-06, status=1, ipAttribution=)]
    2019-07-08 wincls
  8. [GetPortalCommentsPageByObjectIdResponse(id=1738562, encodeId=1f7d1e385627a, content=<a href='/topic/show?id=a9dd4e63c4' target=_blank style='color:#2F92EE;'>#CIT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4763, encryptionId=a9dd4e63c4, topicName=CIT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eabf34462441, createdName=12498877m109暂无昵称, createdTime=Mon Jan 13 08:32:00 CST 2020, time=2020-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734150, encodeId=c4f21e34150df, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Sat Feb 01 12:32:00 CST 2020, time=2020-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1797038, encodeId=db171e97038e6, content=<a href='/topic/show?id=ee06222067f' target=_blank style='color:#2F92EE;'>#中性粒细胞外陷阱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22206, encryptionId=ee06222067f, topicName=中性粒细胞外陷阱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c5e117, createdName=lujian, createdTime=Sun Jun 07 23:32:00 CST 2020, time=2020-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783219, encodeId=ac2e1e83219d6, content=<a href='/topic/show?id=34e54e7432' target=_blank style='color:#2F92EE;'>#Citryll#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4774, encryptionId=34e54e7432, topicName=Citryll)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d521144, createdName=wrj0121, createdTime=Fri Jan 03 08:32:00 CST 2020, time=2020-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296706, encodeId=09371296e0627, content=<a href='/topic/show?id=29c82219e47' target=_blank style='color:#2F92EE;'>#中性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22197, encryptionId=29c82219e47, topicName=中性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3883266, createdName=yykkxiaodou, createdTime=Mon Jul 08 04:32:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459075, encodeId=131814590e5ba, content=<a href='/topic/show?id=c2258886959' target=_blank style='color:#2F92EE;'>#融资#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88869, encryptionId=c2258886959, topicName=融资)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=61b96121455, createdName=zhao4618, createdTime=Mon Jul 08 04:32:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553777, encodeId=10ea1553e77db, content=<a href='/topic/show?id=5332126e5b5' target=_blank style='color:#2F92EE;'>#NETs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12675, encryptionId=5332126e5b5, topicName=NETs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a16414422875, createdName=wincls, createdTime=Mon Jul 08 04:32:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580158, encodeId=b23c158015816, content=<a href='/topic/show?id=bd2529020e1' target=_blank style='color:#2F92EE;'>#免疫性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29020, encryptionId=bd2529020e1, topicName=免疫性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df0516593209, createdName=124988c7m100暂无昵称, createdTime=Mon Jul 08 04:32:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048117, encodeId=642e104811e1b, content=又是钱!医学需要投资呀,赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Jul 06 16:32:00 CST 2019, time=2019-07-06, status=1, ipAttribution=)]
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    2019-07-06 CHANGE

    又是钱!医学需要投资呀,赞!

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