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Stroke:步数与脑小血管疾病的关系

2020-11-07 MedSci原创 MedSci原创

在健康男性中发现步数与CSVD患病率之间呈J形关系,在每天8000至10000步的参与者中观察到的风险最低。较高的步数也与较低的WMH量相关。

脑小血管疾病(CSVD)是大脑老化的常见亚临床特征。每天步行可能有助于预防CSVD。近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在调查健康日本男性行走步数与CSVD之间的关联。

研究人员分析了680名参加了这项观察性研究的无卒中男性的数据,他们使用计步器在基线(2006-2008年)评估了7天的步数。在随访(2012-2015年)期间,根据磁共振成像上深部和皮层下白质高信号(WMH)、脑室周围高信号、腔隙性梗塞和脑微出血对CSVD进行了评估。研究人员使用logistic回归进行分析,根据步数计数的四分位数计算了CSVD的调整后比值比(CI为95%)(参考:Q1)。研究人员还使用分位数回归探究了步数与WMH量之间的关联。

每天的步数与较低的比值比显著相关,与Q1(≤6060步/天)相比,最低Q3(8175-10614步/日)的受试者深层和皮层下的WMH(比值比为0.52 [95%CI为0.30-0.89]),脑室周围高信号(0.50 [95%CI为0.29–0.86])和腔隙性梗塞(0.52 [95%CI为0.30–0.91])更高,而脑微出血则没有。在步数和WMH体积之间观察到负向线性关联。这些关联与年龄、吸烟和饮酒状况无关,并且在调整血管危险因素后保持一致。

由此可见,在健康男性中发现步数与CSVD患病率之间呈J形关系,在每天8000至10000步的参与者中观察到的风险最低。较高的步数也与较低的WMH量相关。

原始出处:

Mohammad Moniruzzaman,et al.Relationship Between Step Counts and Cerebral Small Vessel Disease in Japanese Men.stroke.2020.https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.030141

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1774654, encodeId=d2991e7465432, content=<a href='/topic/show?id=d0e24e171d1' target=_blank style='color:#2F92EE;'>#小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47171, encryptionId=d0e24e171d1, topicName=小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c7a38663370, createdName=kord1995, createdTime=Tue Jul 13 02:43:45 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897959, encodeId=62ca89e959f1, content=没事,多散散步吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Nov 09 14:25:36 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480861, encodeId=2bf1148086116, content=<a href='/topic/show?id=de508482e61' target=_blank style='color:#2F92EE;'>#脑小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84827, encryptionId=de508482e61, topicName=脑小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76c57719730, createdName=thinkibmz_44722596, createdTime=Mon Nov 09 00:43:45 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498788, encodeId=65e61498e8822, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Mon Nov 09 00:43:45 CST 2020, time=2020-11-09, status=1, ipAttribution=)]
    2020-11-09 Jessica

    没事,多散散步吧

    0

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