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BMC Cancer:咖啡喝多了会增加胃癌风险吗?

2015-12-30 Seven L 译 MedSci原创

一些观察性研究表明,咖啡摄入量可能与胃癌风险增加有关,但目前各研究结果不一致。因此研究者进行了一项荟萃分析,评估胃癌风险和咖啡摄入量的关系,并量化两者间的剂量-反应关系。研究者检索了PubMed、EMBASE等数据库中相关前瞻性研究,使用随机效应模型计算汇总后风险估计和95%置信区间;使用I(2)统计值估计异质性;使用Begg检验和Egger检验评估发表偏倚。该荟萃分析最终纳入了13个前瞻性研究共

一些观察性研究表明,咖啡摄入量可能与胃癌风险增加有关,但目前各研究结果不一致。因此研究者进行了一项荟萃分析,评估胃癌风险和咖啡摄入量的关系,并量化两者间的剂量-反应关系。

研究者检索了PubMed、EMBASE等数据库中相关的前瞻性研究,使用随机效应模型计算汇总后风险估计和95%置信区间;使用I(2)统计值估计异质性;使用Begg检验和Egger检验评估发表偏倚。

该荟萃分析最终纳入了13个前瞻性研究共20项独立报告,涉及3368例胃癌患者和1372811名参与者,随访时间4.3-8年。与咖啡摄入量最低的组相比,胃癌风险RR=1.13(95 % CI: 0.94-1.35)。剂量-反应分析表明,每人每天喝3杯咖啡,胃癌风险RR=1.03 (95 % CI; 0.95-1.11)。研究者没有发现咖啡摄入量与胃癌风险间的任何非线性关联(非线性,P= 0.68)。亚组分析表明,美国地区咖啡摄入量最高和最低组相比,胃癌风险RR=1.36 (95 % CI, 1.06-1.75, I (2) = 0 %)。此外,不到10年的随访数据显示,随着咖啡摄入量的增加,胃癌风险增加25%(RR = 1.25; 95 % CI, 1.01-1.55, I (2) = 0 %)。漏斗图、Begg's和Egger's检验没有发现发表偏倚。

该荟萃结果不支持咖啡摄入量与胃癌风险的关系,但是根据美国的不到10年的随访组数据,研究人员发现随咖啡摄入量增加胃癌风险增加。未来还需要更多的相关研究探究两者间的关系。

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    2016-08-23 sjq027
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    2016-02-24 小丸子1995

    凡事都要有个度

    0

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    2016-01-20 康乃馨

    有好处,当然也有坏处了

    0

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    2016-01-13 路路

    我每天要喝好多~

    0

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    2016-01-07 I come

    呵呵

    0

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    2016-01-03 jetleo

    该荟萃结果不支持咖啡摄入量与胃癌风险的关系

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1974667, encodeId=3b7a19e466712, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Thu Oct 27 18:51:00 CST 2016, time=2016-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061501, encodeId=f69b206150102, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Tue Aug 23 20:51:00 CST 2016, time=2016-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65435, encodeId=953f6543516, content=凡事都要有个度, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=23bd1690776, createdName=小丸子1995, createdTime=Wed Feb 24 17:08:00 CST 2016, time=2016-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=58568, encodeId=eb9658568f5, content=有好处,当然也有坏处了, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b111681748, createdName=康乃馨, createdTime=Wed Jan 20 21:36:00 CST 2016, time=2016-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57058, encodeId=e8e85e0589a, content=我每天要喝好多~, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG56963B8248B138520.jpg, createdBy=61841679327, createdName=路路, createdTime=Wed Jan 13 20:04:00 CST 2016, time=2016-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52809, encodeId=e69952809eb, content=呵呵, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Thu Jan 07 22:59:00 CST 2016, time=2016-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51550, encodeId=8299515501e, content=该荟萃结果不支持咖啡摄入量与胃癌风险的关系, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Sun Jan 03 23:39:00 CST 2016, time=2016-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50969, encodeId=f07050969ec, content=其实,物本无害过则为灾,咖啡可以预防很多肿瘤,但是从某种意义上说,咖啡也是一种刺激性物质,食用过多了可能会带来一些潜在的风险,包括胃溃疡等的发生有可能会增加。, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Jan 01 10:53:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50941, encodeId=8fc950941a1, content=现在统计好太有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 09:32:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50942, encodeId=75af50942d1, content=反而做研究机制的不多了, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 09:32:00 CST 2016, time=2016-01-01, status=1, ipAttribution=)]
    2016-01-01 medcardio

    其实,物本无害过则为灾,咖啡可以预防很多肿瘤,但是从某种意义上说,咖啡也是一种刺激性物质,食用过多了可能会带来一些潜在的风险,包括胃溃疡等的发生有可能会增加。

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1974667, encodeId=3b7a19e466712, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Thu Oct 27 18:51:00 CST 2016, time=2016-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061501, encodeId=f69b206150102, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Tue Aug 23 20:51:00 CST 2016, time=2016-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65435, encodeId=953f6543516, content=凡事都要有个度, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=23bd1690776, createdName=小丸子1995, createdTime=Wed Feb 24 17:08:00 CST 2016, time=2016-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=58568, encodeId=eb9658568f5, content=有好处,当然也有坏处了, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b111681748, createdName=康乃馨, createdTime=Wed Jan 20 21:36:00 CST 2016, time=2016-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57058, encodeId=e8e85e0589a, content=我每天要喝好多~, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG56963B8248B138520.jpg, createdBy=61841679327, createdName=路路, createdTime=Wed Jan 13 20:04:00 CST 2016, time=2016-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52809, encodeId=e69952809eb, content=呵呵, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Thu Jan 07 22:59:00 CST 2016, time=2016-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51550, encodeId=8299515501e, content=该荟萃结果不支持咖啡摄入量与胃癌风险的关系, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Sun Jan 03 23:39:00 CST 2016, time=2016-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50969, encodeId=f07050969ec, content=其实,物本无害过则为灾,咖啡可以预防很多肿瘤,但是从某种意义上说,咖啡也是一种刺激性物质,食用过多了可能会带来一些潜在的风险,包括胃溃疡等的发生有可能会增加。, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Jan 01 10:53:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50941, encodeId=8fc950941a1, content=现在统计好太有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 09:32:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50942, encodeId=75af50942d1, content=反而做研究机制的不多了, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 09:32:00 CST 2016, time=2016-01-01, status=1, ipAttribution=)]
    2016-01-01 lu2996

    现在统计好太有用

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1974667, encodeId=3b7a19e466712, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Thu Oct 27 18:51:00 CST 2016, time=2016-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061501, encodeId=f69b206150102, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Tue Aug 23 20:51:00 CST 2016, time=2016-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65435, encodeId=953f6543516, content=凡事都要有个度, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=23bd1690776, createdName=小丸子1995, createdTime=Wed Feb 24 17:08:00 CST 2016, time=2016-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=58568, encodeId=eb9658568f5, content=有好处,当然也有坏处了, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b111681748, createdName=康乃馨, createdTime=Wed Jan 20 21:36:00 CST 2016, time=2016-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57058, encodeId=e8e85e0589a, content=我每天要喝好多~, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG56963B8248B138520.jpg, createdBy=61841679327, createdName=路路, createdTime=Wed Jan 13 20:04:00 CST 2016, time=2016-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52809, encodeId=e69952809eb, content=呵呵, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Thu Jan 07 22:59:00 CST 2016, time=2016-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51550, encodeId=8299515501e, content=该荟萃结果不支持咖啡摄入量与胃癌风险的关系, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Sun Jan 03 23:39:00 CST 2016, time=2016-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50969, encodeId=f07050969ec, content=其实,物本无害过则为灾,咖啡可以预防很多肿瘤,但是从某种意义上说,咖啡也是一种刺激性物质,食用过多了可能会带来一些潜在的风险,包括胃溃疡等的发生有可能会增加。, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Jan 01 10:53:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50941, encodeId=8fc950941a1, content=现在统计好太有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 09:32:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50942, encodeId=75af50942d1, content=反而做研究机制的不多了, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Fri Jan 01 09:32:00 CST 2016, time=2016-01-01, status=1, ipAttribution=)]
    2016-01-01 lu2996

    反而做研究机制的不多了

    0

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