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Gastrointest Endosc：Barrett食管发展成食管肿瘤的风险！

2021-02-07 Nebula MedSci原创

Barrett食管食管肿瘤不典型增生
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Barrett食管是食管癌的唯一明确的癌前病变。

Barrett食管(BE)，即食管远端的鳞状上皮化生成了带有杯状细胞的柱状上皮，多见于慢性胃食管反流病患者。Barrett食管是食管癌的唯一明确的癌前病变。目前对携带不确定异型增生(IND)的Barrett食管（BE-IND）患者肿瘤进展风险的认识还是来源于小型回顾性和病理学登记研究。 本研究是一项多中心队列研究，旨在确定BE-IND患者的肿瘤发病率。 研究流程 纳入了来自2个学术中心的确诊为BE-IND的患者，如果受试患者既往无异型增生的证据，则接受长达1年及以上的内镜随访(FU)。 无肿瘤存活率 1997年-2017年期间，共筛查了465例BE-IND患者，排除了223例(48.0%)。在纳入分析的242例患者中，184例(76.0%)在随访期间未发现异型增生。23例(9.5%)患者存在肿瘤(低度异型增生[LGD]20例、高度异型增生[HGD]2例、粘膜内癌[IMC]1例)；中位随访了1.5年（IQR 0.6-3.2年）后，35例(14.5%)新发肿瘤(LGD 27例，HGD 5例，IMC 3例)。 BE长度与发生肿瘤的相关性 所有肿瘤和HGD/IMC的发病率分别为3.2例/100

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    2021-11-25 ms3000001096233086

    学习了

    0

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    2021-06-29 xiangyuzhou971

    #EST#

    0

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    2021-12-29 ms24272190615788285182

    #AST#

    0

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createdBy=96d4340, createdName=ysjykql, createdTime=Mon Oct 04 23:00:30 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073242, encodeId=9a4b20e3242d9, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sun Jul 11 03:00:30 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943413, encodeId=ea6c194341352, content=<a href='/topic/show?id=fa761e2916a' target=_blank style='color:#2F92EE;'>#Test#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17291, encryptionId=fa761e2916a, topicName=Test)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Wed Oct 27 17:00:30 CST 2021, time=2021-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1971785, encodeId=eca519e17854a, content=<a href='/topic/show?id=7e1010110675' target=_blank style='color:#2F92EE;'>#食管肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101106, encryptionId=7e1010110675, topicName=食管肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Thu Apr 22 22:00:30 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=924929, encodeId=7d8b924929f6, content=积分怎么获得, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=21455386044, createdName=ms8000000911130373, createdTime=Tue Feb 16 18:40:27 CST 2021, time=2021-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393710, encodeId=ed5d1393e1088, content=<a href='/topic/show?id=50cc321084' target=_blank style='color:#2F92EE;'>#Barrett食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3210, encryptionId=50cc321084, topicName=Barrett食管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33b92500139, createdName=12498b37m72暂无昵称, createdTime=Tue Feb 09 13:00:30 CST 2021, time=2021-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437607, encodeId=b067143e607e4, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Feb 09 13:00:30 CST 2021, time=2021-02-09, status=1, ipAttribution=)]
    2021-10-04 ysjykql

    #RET#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1073918, encodeId=a2ec10e39186f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c455696426, createdName=ms3000001096233086, createdTime=Thu Nov 25 19:11:57 CST 2021, time=2021-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051638, encodeId=799d2051638da, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Tue Jun 29 16:00:30 CST 2021, time=2021-06-29, status=1, ipAttribution=), 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createdBy=96d4340, createdName=ysjykql, createdTime=Mon Oct 04 23:00:30 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073242, encodeId=9a4b20e3242d9, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sun Jul 11 03:00:30 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943413, encodeId=ea6c194341352, content=<a href='/topic/show?id=fa761e2916a' target=_blank style='color:#2F92EE;'>#Test#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17291, encryptionId=fa761e2916a, topicName=Test)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Wed Oct 27 17:00:30 CST 2021, time=2021-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1971785, encodeId=eca519e17854a, content=<a href='/topic/show?id=7e1010110675' target=_blank style='color:#2F92EE;'>#食管肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101106, encryptionId=7e1010110675, topicName=食管肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Thu Apr 22 22:00:30 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=924929, encodeId=7d8b924929f6, content=积分怎么获得, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=21455386044, createdName=ms8000000911130373, createdTime=Tue Feb 16 18:40:27 CST 2021, time=2021-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393710, encodeId=ed5d1393e1088, content=<a href='/topic/show?id=50cc321084' target=_blank style='color:#2F92EE;'>#Barrett食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3210, encryptionId=50cc321084, topicName=Barrett食管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33b92500139, createdName=12498b37m72暂无昵称, createdTime=Tue Feb 09 13:00:30 CST 2021, time=2021-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437607, encodeId=b067143e607e4, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Feb 09 13:00:30 CST 2021, time=2021-02-09, status=1, ipAttribution=)]
    2021-07-11 许安

    #GAS#

    0

  6. 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createdBy=96d4340, createdName=ysjykql, createdTime=Mon Oct 04 23:00:30 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073242, encodeId=9a4b20e3242d9, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sun Jul 11 03:00:30 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943413, encodeId=ea6c194341352, content=<a href='/topic/show?id=fa761e2916a' target=_blank style='color:#2F92EE;'>#Test#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17291, encryptionId=fa761e2916a, topicName=Test)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Wed Oct 27 17:00:30 CST 2021, time=2021-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1971785, encodeId=eca519e17854a, content=<a href='/topic/show?id=7e1010110675' target=_blank style='color:#2F92EE;'>#食管肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101106, encryptionId=7e1010110675, topicName=食管肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Thu Apr 22 22:00:30 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=924929, encodeId=7d8b924929f6, content=积分怎么获得, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=21455386044, createdName=ms8000000911130373, createdTime=Tue Feb 16 18:40:27 CST 2021, time=2021-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393710, encodeId=ed5d1393e1088, content=<a href='/topic/show?id=50cc321084' target=_blank style='color:#2F92EE;'>#Barrett食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3210, encryptionId=50cc321084, topicName=Barrett食管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33b92500139, createdName=12498b37m72暂无昵称, createdTime=Tue Feb 09 13:00:30 CST 2021, time=2021-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437607, encodeId=b067143e607e4, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Feb 09 13:00:30 CST 2021, time=2021-02-09, status=1, ipAttribution=)]
    2021-10-27 lqvr

    #Test#

    0

  7. 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createdBy=96d4340, createdName=ysjykql, createdTime=Mon Oct 04 23:00:30 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073242, encodeId=9a4b20e3242d9, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sun Jul 11 03:00:30 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943413, encodeId=ea6c194341352, content=<a href='/topic/show?id=fa761e2916a' target=_blank style='color:#2F92EE;'>#Test#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17291, 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    2021-04-22 fengyi812

    #食管肿瘤#

    0

  8. 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objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Feb 09 13:00:30 CST 2021, time=2021-02-09, status=1, ipAttribution=)]
    2021-02-16 ms8000000911130373

    积分怎么获得

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Feb 09 13:00:30 CST 2021, time=2021-02-09, status=1, ipAttribution=)]
    2021-02-09 12498b37m72暂无昵称

    #Barrett食管#

    0

  10. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=21455386044, createdName=ms8000000911130373, createdTime=Tue Feb 16 18:40:27 CST 2021, time=2021-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393710, encodeId=ed5d1393e1088, content=<a href='/topic/show?id=50cc321084' target=_blank style='color:#2F92EE;'>#Barrett食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3210, encryptionId=50cc321084, topicName=Barrett食管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33b92500139, createdName=12498b37m72暂无昵称, createdTime=Tue Feb 09 13:00:30 CST 2021, time=2021-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437607, encodeId=b067143e607e4, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Feb 09 13:00:30 CST 2021, time=2021-02-09, status=1, ipAttribution=)]
    2021-02-09 zhouqu_8

    #食管#

    0

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