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Cell Metabol:要减肥,肠道菌群告诉你怎么吃

2015-09-15 佚名 生物谷

来自查尔姆斯理工大学研究者的一项最新研究或可基于机体的肠道微生物来指导我们的饮食选择,这对于有效减肥及降低疾病风险非常重要,相关研究刊登于国际杂志Cell Metabolism上,该研究首次成功揭示了机体代谢期间常见的肠道细菌相互作用的分子机制。 文章中,研究者开发了一种新型数学计算平台,其可以帮助预测不同病人对基于其机体肠道微生物组组成的修饰化饮食的反应。研究者Jens Nielsen博士

来自查尔姆斯理工大学研究者的一项最新研究或可基于机体的肠道微生物来指导我们的饮食选择,这对于有效减肥及降低疾病风险非常重要,相关研究刊登于国际杂志Cell Metabolism上,该研究首次成功揭示了机体代谢期间常见的肠道细菌相互作用的分子机制。

文章中,研究者开发了一种新型数学计算平台,其可以帮助预测不同病人对基于其机体肠道微生物组组成的修饰化饮食的反应。研究者Jens Nielsen博士表示,这种方法或可帮助我们轻松鉴别出每一种细菌类型的代谢机制从而来帮助理解人类机体的代谢机制。在人类消化系统中存在高达1000多种不同类型的细菌及其它微生物群落,其中许多细菌都以一种或多种方式进行代谢,而人类肠道微生物组的组成也会因个体不同而异,究其原因研究者目前并不清楚。然而过去很多年间研究者们进行的多项研究表明,某些疾病和人类肠道微生物组之间存在着千丝万缕的关系。

比如2型糖尿病、动脉硬化以及肥胖症而言,都和肠道微生物群落有关,而且有研究表明肠道微生物群落或许还和抑郁症发病直接相关,当然也对多种癌症疗法的反应存在一定反应。阐明微生物同食物及个体饮食的关系非常复杂,截止到目前为止,研究者很难理解搞清楚这几个因素的因果关联,而在本文研究中研究者通过进行临床试验首次利用数学模型的方法阐明了微生物群落和饮食方式的关联。

研究的出发点就是研究者进行的饮食试验,首先肠道微生物组主要表现为过重病人单一个体的机体特性,其次患者进行减肥饮食,每个人都会进行减肥;然而在肠道微生物组多样性较低的患者中,指示健康风险的多种物质的内容或许会在个体的血液和粪便中降低;Jens Nielsen认为,本文研究对于医生们而言可以轻松识别出哪些过重患者存在高风险的心肌代谢疾病的风险,同时也可以帮助修改患者的饮食及减肥来帮助改善其健康效益。

从长远角度来讲,我们应当增加机体代谢功能不合适的患者机体的肠道菌群,而益生菌是一个不错的选择,比如食用多种酸奶酪等,但最初益生菌的主要作用就是稳定肠道以及创建肠道菌群适宜生长的环境;而新一代的益生菌将会向患者肠道中添加入更多的有益菌群,从而帮助改善患者机体的肠道健康。

原文出处:

Saeed Shoaie, Pouyan Ghaffari,et al.Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome.Cell Metabol.2015

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    2016-05-23 guojianrong
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    2016-06-01 一闲
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    2016-03-25 智智灵药
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    2015-12-30 xyfg98

    要学习

    0

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    2015-09-29 chucklehead

    多喝酸奶

    0

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    2015-09-21 nizongzan

    减肥也是一门学问

    0

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    2015-09-21 nizongzan

    加油,现在平台期,减不下去

    0

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    2015-09-21 nizongzan

    肥胖危害性大

    0

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越来越多的研究者正在调查机体内肠道细菌对其身体健康的影响。例如,2014年11月,Medical News Today报道了两项研究,其中一项研究揭示了机体内的肠道细菌是如何影响自身体重的,而另一项研究探究的是帕金森病与肠道细菌的关系。既往研究中加拿大麦克马斯特大学医学专业的副教授Michael G. DeGrotte和他的同事证明肠道细菌可以影响人们的行为,现在这一观点已经被很多人所熟知和认可。

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据新的一项研究表明,益生菌可通过改变免疫系统与大脑之间的通讯而改善慢性炎症者的行为症状,该研究成果于2015年2月29日在线发表于《神经学杂志》。慢性炎症是指如类风湿性关节炎及炎症性肠道疾病与行为症状(包括肥胖,抑郁及社交退缩)有关。来自卡尔加里大学的研究人员通过喂养益生菌给伴有肝脏炎症的小鼠,发现喂养益生菌后这些行为症状减少了。胃肠道含有大量的微生物称为微生物群,可支持机体进行消化并保持机体免疫

J Immunol:自身免疫性葡萄膜炎的发生与肠道菌群相关

Immunity:自身免疫性葡萄膜炎的发生与肠道菌群相关自身免疫性葡萄膜炎是导致人类失明的一个主要原因。自身免疫性葡萄膜炎是由活化的T细胞所引起,但是具体的哪个部位的T细胞最先激活以及如何激活的尚未可知。8月18日发表于Immunity 的一项新的研究表明,肠道微生物可产生一种仿视网蛋白的分子,这种分子极有可能会激活T细胞导致疾病的发生。“鉴于共生细菌的种类之多,如果它们可以模仿视网膜蛋白,那么它

Science:健康不健康 看看肠道菌群就知道

随着研究的深入,我们已经知道在我们的肠道中居住着几千种不同的细菌,并将其称之为肠道菌群,这些肠道细菌的变化对人类健康具有重要影响。但是我们对于这种影响仍然了解较少。近日,来自魏茨曼研究所的科学家们在著名国际学术期刊science上发表了一项最新研究进展,他们从一个全新的角度阐述了肠道菌群对人类健康的作用。在这项研究中,研究人员首先采用了目前菌群研究的常用方法--基因组测序--对样本中所有类型细菌的

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