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JAMA:老年人心血管健康水平与痴呆风险研究

2018-08-22 zhangfan MedSci原创

研究认为,高龄老人保持健康的心血管水平可显著降低其后继痴呆及认知衰退风险

近日,研究人员根据美国心脏协会(AHA)7项指标,考察了老年人群心脏健康水平与痴呆和认知衰退风险之间的相关性。

65岁以上,基线无心脏病和痴呆史的老年人参与研究,患者在1999-2016年间接受神经心理学测试以及系统性的痴呆评估。AHA 7项心脏健康指标包括:无吸烟、BMI<25、规律运动、每周2次鱼类涉入以及每日至少3次涉入水果和蔬菜、胆固醇水平<200 mg/dL、空腹血糖<100 mg/dL、血压<120/80 mm Hg。研究的主要终点是痴呆和认知衰退与AHA健康水平之间的关系。

6626名志愿者参与研究,平均年龄73.7岁,女性4200人,符合0-2项、3-4项以及5-7项AHA健康标准的参与者人数分别2412 (36.5%), 3781 (57.1%)以及433 (6.5%)。随访8.5年,745人确诊痴呆。符合0-1项AHA健康指标人群每100患者年的痴呆事件为1.76,符合2,3,4,5以及6-7项AHA健康标准人群的痴呆风险,相对于0-1项人群分别减少0.26、0.59、0.43、0.93以及0.96(每100患者年)。多因素模型显示每增加1项健康生活指标的痴呆风险下降至0.90,认知衰退风险下降至0.92。在基线时,每1项健康生活指标的对认知衰退风险降低的比值比为0.031,坚持6年则达到0.068,坚持12年则达到0.072。

研究认为,高龄老人保持健康的血管水平可显著降低其后继痴呆及认知衰退风险。

原始出处:


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    2018-08-23 changjiu

    谢谢啦,学习一下谢谢

    0

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    2018-08-22 三不猴

    挺好

    0

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    2018-08-22 junJUN

    老年人痴呆何药可用??

    0

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    2018-08-22 flysky120

    老年人的痴呆与心血管关系

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